Mental Health Valdoxan - how much time is it take to downregulate the 5-ht 2c receptors

[DanielVonCalabrese]

1. Valdoxan - how much time is it take to downregulate the 5-ht 2c receptors?
2. What would happen If I take it twice a day 50mg? Would it be faster the downregulation?
3. And what about the combo Valdoxan with Zoloft 1x50mg or 2x50mg? Is it a good choise for chronic and treatment resistant depression?

Thanks.

 

[Abject]

I'd be more worried about my melatonin receptors and the withdrawal from Agomelatine when it occurs, more than your 5-HT2C receptors.
I don't know how much you've looked into it, or how much you care about pharmaceutical companies and what you're putting in your body but Servier are the company who make it and they sold the rights to Novartis for the US market but they dropped it due to the lack of evidence for it's efficiency, as well as it's toxicity (watch out for your liver son)
It has a short half-life, so you could take it twice a day if you wanted. That's assuming you're prescribed 100mg and not 50mg. The usual therapeutic range is from 30-60mg as far as I can tell.
Spacing out how often you take it won't speed up downregulation.
Even when downregulation occurs, it's not like you'll magically feel good.
You can mix Agomelatine with other drugs as there isn't any risk for serotonin syndrome, but if you're just starting on the Agomelatine it would be counterproductive to add another drug as you wouldn't know which one is doing what.
Here's a dose of skepticism, should you want it.

Best of luck.
Can I suggest looking into RIMA's (reversible MAO-A inhibitors)
I'm currently on Mocblobemide, after trying some SSRI's and an SNRI.
My psych tried to put me on Agomelatine, but I declined.
He gave me the options of roboxetine, mirtazapine, and this (moclobemide)
The mirtazapine seems like a good back up if this doesn't work, assuming I can't cosy him into prescribing some Tranylcypromine
and I restrain from telling him I'll kill myself and it's his negligence to give me some dexies is the reason I ain't there for the next session

fuck psychiatry is tricky shit OP
good luck

 

[Vaya]

and I restrain from telling him I'll kill myself and it's his negligence to give me some dexies is the reason I ain't there for the next session

You withhold life-or-death information from your doctor in order to get Dexedrine? Or am I misreading?

 

[DanielVonCalabrese]

...it won't speed up downregulation.

Hi, Abject. Why is that?

 

[Abject]

Vaya I worded that badly. If I were to try and reword it; he has the power to prevent my death. Dexedrine was just the first thing that came to mind, I haven't asked him for stims and the drug itself is irrelevant (to an extent)
in what you quoted, I was saying that (at times) I feel like telling him I am suicidal and that if I had something prescribed to make life tolerable I might be able to work on building other things
I was just having a little rant because the hypocrisy of power that undermine the very nature that we have health care
When ones ability to prescribe (something helpful) is paramount to helping your patient it can be offensive.

Spreading out your doses won't speed up downregulation because the Agomelatine is still going to be affecting your receptors at the same rate. It's a matter of your body adjusting to the drug, taking more than necessary won't make your brain think it's been longer than it should be.

 

[Vaya]

Thanks for the clarification, Abject