Unusual reaction from Tramadol/diazepam/weed combo

[PixPie]

Yesterday I had 400mg of Tramadol SR (spaced out over the course of the day).
In the evening, I had 10mg diazepam and an antibiotic - trimethoprim 300mg.
Then I smoked a pipe and my heartbeat went through the roof.
It wasn't weed paranoia, because I got my partner to feel my heartbeat and he said it was beating really fast (he told me this today, so as not to freak me out even more than I was already).
I thought I was dying and my vision began to blur.

Can anybody explain these physical effects?
I had never experienced anything like it and I had similar combos in the past.
I have a decent Tramadol tolerance (I take it for sciatic pain).
The only thing different this time was the antibiotics.

 

[Venrak]

Sometimes, even to seasoned users, Cannabis can cause a rapid increase in heartbeat and blood pressure that can be quite surprising. It happened to me the other night, out of the blue. After a hit of resin, none the less.

I'm thinking it was simply a reaction to the Cannabis.

 

[laCster]

^this

plus tramadol is an NRI so the ultram and the marijauna caused your side effects

 

[PixPie]

Thanks, guys

 

[Venrak]

plus tramadol is an NRI so the ultram and the marijauna caused your side effects

Yeah, that probably didn't help at all.

Answered & Closed.

 

[pasha]

Just wanted to reinforce what has been said that tachycardia (fast heartbeat) from mixing serotonergics and marijuana is a documented side-effect hence why they're contraindicated:

• Selective Serotonin Reuptake Inhibitors (SSRIs) - Sertraline (Zoloft), Paroxetine (Aropax), Citalopram (Cipramil), Fluoxetine (Prozac), Fluvoxamin (Luvox);
• Monoamine Oxidase Inhibitors (MAOIs) – Moclobemide (Aurorix), Phenelzine (Nardil);
• Newer antidepressants – Mirtazapine (Avanza), Venlafaxine (Efexor) and Reboxetine (Edronax).

Very little research has been conducted on the effects of using marijuana while taking prescribed antidepressant medication. The side-effects of antidepressants can be similar to those produced by marijuana use however, and these include the following:

• Abnormally fast heartbeat (tachycardia);
• Dizziness;
• Anxiety;
• Panic;
• Drowsiness;
• Nausea;
• Confusion.