I don't think the anxiety has anything to do with not rolling, I get anxious all the time thinking about rolls but I still roll hard every time.
You said every time you drink n then pop you roll fine? I think you might just have weaker pills, because whenever i'm drunk and then pop 1 I feel the roll even harder compared to just dropping 1 when i'm sober, so the drinking might be helping make the roll strong enough to feel for you.
And you said you took more pills and felt "something", so I def think the pills are just on the weaker end. If I were you I would just take 1.5-twice the initial amount of pills you normally do, and if you still don't feel anything in an hour and half pop some more and if you still don't feel anything I would just say you were unlucky and got a bad select few in your batch.
For me even if I roll consecutive days in a row, which is bad, I'll still feel 1 pill everytime, just not as strong the next day I do it. So I don't think it's because you need a break, which does help, but to increase your initial dosage especially if you're not drinking.