Turmeric, Curcumin, Piperine and P450 Enzyme Inhibition

[perfectphase]

"Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor"
Article PDF: http://dmd.aspetjournals.org/content/36/8/1594.full.pdf+html

HTML: http://dmd.aspetjournals.org/content/36/8/1594.full

It appears that Curcumin from Turmeric and Piperine from Black Pepper (commonly taken together) both inhibit a number of Cytochrome P450 enzymes. P450's such as CYP3A4 and CYP2D6 are responsible for a large amount of drug metabolism and the use of Curcumin and Piperine might explain some of the reactions people are experiencing upon co-administration with drugs such as Benzodiazepines and Amphetamine type drugs... Interesting stuff and something people, especially those using this forum, should be aware of.

 

[panic in paradise]

yeah, thanks, i take Curcumin daily...and actually just drank milk with Turmeric and a loose tea blend with BlackPepper in it.

no AMPS here, or benzos now, but i will definitely be consuming Turmeric for life and maybe a BZD...


i am curios now, if Ashwagandha has any play with the CYP3A4 Inhibitor, the stuff knocks-me-out consuming over 250mgs, and that is a mid-range suggested dose for health benefits.

 

[apsig]

Not to derail things, but what benefits have you gained from curcumin administration? I've been interested in the past but haven't gotten around to it yet.
(Feel free to private message a reply if you don't wish to clutter the thread with this borderline off-topic talk.)

 

[yoyoman]

I've been taking curcumin nearly daily. i also have been taking d-meth (low doses in capsules as a replacement for dexedrine, like 15-30mg depending on how i feel, i dont get real high off the stuff.)

I can't really tell if it does anything or not.. most i've taken is a couple at once. The one i have is doctor's choice with that piperine. The meth/benzo combo has literally flipped my life upside down i'm social etc. Wont' even go into the benefits... But I'm curious at what level (how many capsules at once) it would take to 'feel' anything from the circumin. The meth seems to last 24 hours (basically, all day long) until i pop a seroquel at night (and get forced sleep for 8 hours, which totally stops psychosis)

 

[MagickalKat777]

You need a high potency (95%) curcumin extract from a reliable manufacturer to notice any real changes and at doses that usually hover around 1000mg of it a day. Be careful though because curcumin is a selective MAO-A inhibitor and at higher doses this becomes much more apparent. I have had hypertensive crisis before from 5-MeO-aMT (the jury is still out on MAO inhibition but considering its ridiculously long life span in the human body along with the fact that it is essentially a modified serotonin molecule made to pass the BBB would say that inhibits MAO in some way because I can't think of another tryptamine that doesn't get attacked by MAO) after eating a big meal (stuff always made me hungry, no idea why, most report total absence of hunger much like amphetamine but I eat on all amphetamines too) that included a lot of cheddar cheese. My favorite - sharp white cheddar quesadillas with bacon.

I honestly wouldn't mess with something that inhibits P450 OR MAO because a lot of common substances, both organic and inorganic, are made harmless and expelled without problems.

 

[attempt4]

I use Turmeric and Black Pepper with my Kratom sometimes, haven't done it for a while and can't remember if I noticed any effect. I do recall feeling something more, but it could have been placebo.

 

[laffingrass]

they spike curcumin with piperine for bioavail, but there is a new product out called curamin