Opioids Tums and oxycodone (bioavailability/potentiation)

[infraredz]

As a pain patient who has started to develop a tolerance to my 10/325 percocets (every 6 hours), I have a few questions.

Other than CYP3A4 inhibitors (cimetidine and grape fruit seed extract, which I take 45mins before dosing), I am looking for another potentiator. Now, what is the pharmacological/physiological reason for taking antacids, and does it apply to Percocet in particular?

It's my understanding that oxycodone is in the form of a hydrochloride salt. What effect would antacids have other than lowering the ph of the stomach? If I'm correct, very little (if any) of medications can be absorbed in the stomach itself, so is the idea to 'protect' the drug from acidic PHs? I can't find any information that acids harm oxycodone...

I mean, after all, oxycodone is combined with an acid.


Also, isn't cimetidine an antacid itself? If I'm taking that (400-600mg every 6 hrs) then why take tums?

 

[RedRum OG]

IME white grapefruit is incredibly effective with oxycodone. Cimetidine is good too but not as much. Never used tums but oxycodone is 80-90% efficient orally, so there's not much room for improvement as far as the drug making it into your blood. However you can increase the duration/power a ton by using the enzyme inhibitiors.

And yes cimetidine does reduce stomach acid too

 

[NeighborhoodThreat]

You started the same thread here. Please don't cross-post the same thread in multiple forums.