Tryptamines are to Serotonin as Phenethylamines are to Dopamine as ?? is to Histamine

[i are spectre]

mast cells.

 

[sir_thizzalot]

mast cells.

What? Explain more, even googling that I don't know how it really relates to what we were talking about.

 

[atrollappears]

I don't think there are really a family of chemicals related to histamine as there are for 5-HT/NAS/melatonin and DA/NE/epinephrine. As sekio said though H3 antagonists are interesting.

 

[Perico los palotes]

Histamine derivatives are not fun because the histamine receptor is not as nearly as "fun" as DA/NE/SER.

Compare alpha-methyl histamine - (???) with alpha-methyl-tryptamine/phenethylamine... both are powerful psychostimulants.

The problem is, histamine receptors control things like immune system response, gastric acid secretion, wakefulness, but as far as we know they don't really have a "central" effect.

Also, the old monoamine theory that dopamine = confidence and serotonin = happiness is a total crock of shit, there are too many factors involved to correlate a mood and a neurotransmitter.

Serotonin also has peripheral effects, and dopamine also. Like in the coagulation process and inmunoresponse.

But the histamine mediated response in the inmune system, is not a joke.