• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe | Cheshire_Kat

Tryptamine Sensitivity?

telepathetic

telepathetic

Bluelighter
Joined
Jan 16, 2010
Messages
2,278
My fiance goes nuts on tryptamines--literally. On phenthylamines (mescaline, 2c-i, mdma, etc) she is very clear headed and coherent, on tryptamines it is the direct opposite. During the comeup she'll have alot of anxiety, then during the peak she'll be having lots of fun. Directly following the peak she goes into a shizotypical state. This happened first at our house, on one of our alone trips-- on three hits of some good blotter. It didn't last too long, maybe an hour or two; but she was happy the whole time. The next was at a festival, on two hits of better quality blotter, for four hours or so she was having a horrible time, extremely frightened. The last was last night, on 4-aco-dmt. She took the smallest dose of the 4 who took it. Right after the peak, it happened as it does on tryptamines. She becomes incoherent, not making any sense. You can ask her a question, and she'll be able to answer it correctly, like "who is the president? whats your birthday? whats your full name", but other than that she'll string out random words like "i'm tired....jesus? because i'm tired...". I'll be sitting and shes like "come lay with me!!", I'll respond "not right now sweetie" and she'll be like "why?!", I'll say "why do you need me", and she'll say "because i need to pee". She'll tell me random things like "i've got your child in me--i'm pregnant. sorry i didn't tell you", or "i'm sorry... its okay, we're together.. jesus and god again". She'll repeat words people say over and over again. On two occasions she urinated herself, one because she thought it would solve the universe, one because she didn't want to get up. It's hard for people who don't know her as well to realize she's stuck in thought-loops..but when they do they see what I mean. Then there's a sudden return to reality where she can start to talk normally and hold a conversation. Is she just extremely sensitive to tryptamines or is there something we need to worry about?
 
That sounds strange beyond what psychedelics alone have done to anyone I know.

I would suspect some mental condition that might benefit from treatment or atleast examination, though I have no idea which condition it might be.
 
Judging just by your description of her behavior on tryptamines i would guess she has some underlying mental issues.

But you say she reacts fine when taking 2c's and mescaline.

And i would think someone who has underlying mental issues would react similarly to those as she would to tryptamines.

So honestly, i really dont know what to think about it.

Maybe she is just really sensitive to tryptamines.
Its not unheard of.

And tryptamines tend to be a bit stronger then PEA's in how they affect your thought processes.
 
i have a similar sensitivity to tryptamines, including the thought-loops and yes urinating myself. haven't had a bad experience with phens yet, though i have kept my doses of 2c-e deliberately low.

i would suggest that you drop her dose to half or even less, or just avoid tryptamines altogether. does she have any insecurities or anxiety while sober? does she recall anything from her temporary psychosis that you can talk her though? be prepared to dig deep, she may discover repressed memories that are frightening her into closing off during the most intense parts of her trips.
 
Yeah, she has many insecurities and anxieties that we talk through once that ends. I don't think its an underlying mental issue (other than maybe anxiety) because of the fact that as soon as the main aspects of the trip are over for everyone else, she returns to normal, and there is no lasting psychosis. She recalls pretty much all of the trip, and it's very similar to my extreme dmt breakthrough, billions of realitys combining into one going with an audio wave and switching up as soon as you get it, kind of what I get but she lets go completely, and can't do otherwise.
 
yourtman: Coincidentally enough, I just updated this thread where I have a (seemingly) similar situation with my wife. So far for her it's: tryptamines 0 (of 2 mushroom attempts) and phenethylamines 1 (we tripped yesterday on 2c-i). I was thinking to suggest 4-Aco-DMT for her next trip, but given your fiance's reaction, I wonder if we should expect similar. Then again, maybe their issues are unrelated. :)
 
Extreme sensitivities exist. I was always pretty sensitive to Tryptamines, and I developed more and more of a reverse tolerance as time went on. Eventually I developed some HPPD, so I guess my tolerance is now 0mg to be slightly tripping... Point is, near the end of it all I dosed 15mg of 4-AcO-DiPT (fumarate), expecting a light trip and had complete ego death the entire time. I had a good time, but it felt more like a rough DMT breakthrough that lasted 2.5 hours.

Everyone has a significantly different brain, so dosages are just rough guidelines. If she really wants to take a tryptamine again, shoot very low like 2-4mg. Worst case, nothing happens, best case, she has a great time and has a normal intensity trip.

I might be a little worried about HPPD though. I feel that reverse tolerance, or very low tolerance may leave you more likely to develop HPPD. That's just my feelings from personal experience and it makes sense to me personally. If you need less and less to trip, maybe eventually the amount to pseudo-trip might reach 0.
 
cegli said:
Extreme sensitivities exist. I was always pretty sensitive to Tryptamines, and I developed more and more of a reverse tolerance as time went on. Eventually I developed some HPPD, so I guess my tolerance is now 0mg to be slightly tripping... Point is, near the end of it all I dosed 15mg of 4-AcO-DiPT (fumarate), expecting a light trip and had complete ego death the entire time. I had a good time, but it felt more like a rough DMT breakthrough that lasted 2.5 hours.

Everyone has a significantly different brain, so dosages are just rough guidelines. If she really wants to take a tryptamine again, shoot very low like 2-4mg. Worst case, nothing happens, best case, she has a great time and has a normal intensity trip.

I might be a little worried about HPPD though. I feel that reverse tolerance, or very low tolerance may leave you more likely to develop HPPD. That's just my feelings from personal experience and it makes sense to me personally. If you need less and less to trip, maybe eventually the amount to pseudo-trip might reach 0.
Click to expand...
HPPD is a great thing, nothing to worry about :P
But, a wierd thing that actually validates what you've said is her first couple tryptamine trips were normal intensity- that is she didn't go crazy as she has done recently. Even off the same dose of the same blotter one time.
 
i'm kinda planning on dosing 25 mg 4acodmt for the first (and maybe only) time. this will be my first time with a tryptamine other than shrooms or LSD if that counts. and shrooms were several years ago.

i hope i don't have this kind of sensititvity, or maybe do! :)
 
Indeed, that is definitely a steep dose!
I found that 4-AcO-DMT is extremely smooth feeling on the one hand but it can be
very very strange how secretly deep it can go! Best of luck to you, I hope your
set and setting allow you to attempt this risky dose, if they dont allow for it totally
you might want to reconsider going to no more than 20 mg.
 
porkstock said:
i'm kinda planning on dosing 25 mg 4acodmt for the first (and maybe only) time. this will be my first time with a tryptamine other than shrooms or LSD if that counts. and shrooms were several years ago.

i hope i don't have this kind of sensititvity, or maybe do! :)
Click to expand...
4-aco-dmt is amazing-- i can sense the same type of truth in it that I can in DMT. Tbh, its very similar to a 6 hour DMT break through. Also, alot of the 4-aco-dmt going around is the fumarate salt, which afaik is not as potent as the HcL salt that most dosages reccomment from. 21mg 4-aco-dmt fumarate = 15mg 4-aco-dmt hcL.
 
As long as these aren't traumatic experiences I wouldn't worry about it. I've spent a much bigger portion of my life muttering incoherently than most people and I feel fine:)

Maybe try super low doses or just stick to phens.

I doubt she has a mental issue if she keeps coming back for more and snaps back to normal. It isn't that unusual to have mild psychosis once in a while. It happens to me when I take too much, maybe she's just sensitive.
 
sorry to kinda derail the thread, but thanks for the advice guys. it will be the fumarate. 25 mg fumarate = ~18 mg HCl

the only reason i'm not starting at 20 mg or lower is b/c this might be my only chance. so i wanna really trip from it. therefore i will definitely wait til the right time, set and setting.
 
I had 20 mg which was a full blown trip but I could have gone higher. I think this was HCl but it might have been fumarate.

Sorry for being useless :D
 
Indeed, that is definitely a steep dose!
I found that 4-AcO-DMT is extremely smooth feeling on the one hand but it can be
very very strange how secretly deep it can go! Best of luck to you, I hope your
set and setting allow you to attempt this risky dose, if they dont allow for it totally
you might want to reconsider going to no more than 20 mg.
Click to expand...
To be honest, no disrespect intended at all..... I find that I enjoy taking much more than 25mg 4-ACO-DMT at once for my trips. I ingest 50-60mg regularly, however I do like tripping very hard. When I first started with it, 25mg was perfect for me... But now, even with no tolerance, I feel I need to push it much farther than 25mg to get the kind of trip I want.

I'm NOT suggesting that you take a high dose your first time. For your FIRST time, definitely do not take more than 25mg...you first need to see how your body reacts to it. I'm just stating that, in my opinion, 25mg isn't a "steep" oral dose -- it's about the intensity of maybe an eighth of shrooms (I'm not saying that isn't intense for a new tripper, it is...but for experienced trippers I wouldn't say that it's steep at all). I took it to ~100mg oral one time, and 50mg IV one time, now THAT's a steep dose.

Let me warn you that IV'ing it (the fumarate salt) illicits a COMPLETELY DIFFERENT FEELING AND INTENSITY. I would never recommend someone pick up a needle, but if you must do it, start with 5mg to get a taste of how it is -- and work your way up slowly. (I will admit IV'ing 4-ACO-DMT can be one of the most mind shattering experiences of your life, but I thoroughly enjoy it when I get the chance) DO NOT DO THIS ALONE, MAKE SURE YOU HAVE SOMEONE THERE WHO'S SOBER AND THAT YOU TRUST -- because I've seen it get pretty ugly (unable to speak, pissing yourself, unable to walk, [rarely] delirious thoughts, extreme confusion) -- I once had to physically restrain someone (who was on 30mg IV, which is steep) so that they wouldn't run out of my house naked preparing for the end of the universe. You've been warned
 
Last edited:
I think the simple answer is people just get weird on psychedelics. I know I do some fucked up shit sometimes haha. Last time I did shrooms I ended up repeatedly trying (and failing) to do a front flip, while saying "How many numbers are good numbers to eat?" over and over and over again. This went on for about 10 minutes. I was well aware of it, and enjoying it thoroughly :) Sometimes it just feels good to really let go and let something else take you over.
 
vacathizzle said:
I think the simple answer is people just get weird on psychedelics. I know I do some fucked up shit sometimes haha. Last time I did shrooms I ended up repeatedly trying (and failing) to do a front flip, while saying "How many numbers are good numbers to eat?" over and over and over again. This went on for about 10 minutes. I was well aware of it, and enjoying it thoroughly :) Sometimes it just feels good to really let go and let something else take you over.
Click to expand...
The only thing that scares me about when she is going thru it, even when shes enjoying it, is for the whole5-6 hours she can't sober her self up at all and hold a conversation, haha.
 
You must log in or register to reply here.
Top