Tryptamine Question

[TooLate]

Hello. I have a question related to Psilocin /Psilocybin mushrooms (4-Ho-DMT) compared with N,N-DMT or 5-MeO-DMT. My friend basically denies that low doses of smoked N,N-DMT or 5-MeO-DMT cannot be similar to shroomies when I dispute they would be similar. I've read multiple times on other message boards that they're very similar molecules and may result in similar experiences depending on dose. He has never done mushrooms but I have twice. Neither of us have used N,N-DMT, but he recently purchased mushrooms and has decided not to do them until he's ready. But, now he currently desires DMT which I find odd when mushrooms may theoretically produce a similar, yet milder experience due to structural similarities. What do you think? Are they similar or not? I think they are except for the fact that DMT has a shorter duration and may be significantly more intense while psilocybin has a longer duration but milder effect.
But aren't they in fact, still very much alike?

"psilocybin(4-PO-DMT) and dmt(nn-dmt) are similar molecular structures. they are both tryptamines and on the right doses mushrooms take on more and more dmt like characteristics. this is more noticeable for those who have smoked dmt and payed attention."

 

[Addam]

I see a world of difference between mushrooms and DMT. In fact, I just had a tiny hit of DMT :D and I can't really compare it to any of my mushroom experiences. There are similarities, but the experiences are just too different for me.
Now, a person not versed in a range of psychedelics would probably find more similarities than I.

 

[TooLate]

I see a world of difference between mushrooms and DMT. In fact, I just had a tiny hit of DMT :D and I can't really compare it to any of my mushroom experiences. There are similarities, but the experiences are just too different for me.
Now, a person not versed in a range of psychedelics would probably find more similarities than I.

Well, I guess I won't know for sure then until I'm able to compare them. I've done 30 mg of 2C-E and compared it to 150 ug of LSD and was able to identify both the differences and similarities in the two phenethylamine chemicals. They had clear differences and clear similarities but they're very different structurally. I guess I perceive it as structural relation defines the chemical's effects. But, that's probably very incorrect.

 

[an rud is annamh]

Well, I guess I won't know for sure then until I'm able to compare them. I've done 30 mg of 2C-E and compared it to 150 ug of LSD and was able to identify both the differences and similarities in the two phenethylamine chemicals. They had clear differences and clear similarities but they're very different structurally. I guess I perceive it as structural relation defines the chemical's effects. But, that's probably very incorrect.

That's not very incorrect at all - it's called structure-affinity relationship and is a big topic in modern drug design.

However, LSD is neither a substituted phenethylamine or a substituted tryptamine. Depending on how you look at the molecule, it could be argued to contain both of the originals. The semantics are generally agreed that both have a parent class (indole) and that LSD is considered an ergoline. Its pharmacology is not dissimilar to either, broadly speaking.

Terence McKenna used to ramble on a lot about how mushrooms were "orally active DMT" but as we know (and he knew as well), DMT rendered orally active is noticeably different from either smoked DMT or mushrooms. Ultimately, tryptamines, phenethylamines, beta-carbolines and others can be more or less different from eachother as themselves.