Ive just heard about the variation of the dri and was wondering if anyone could point me in the direction of more info on this. i am looking for binding affinities of dopamine cocaine mdpv petadrone apvp methylphenidate and any other dri compounds if they are even known. i also would like to know of the location of the tropane dri's. im pretty sure the bonding affinithes for mdpv apvp pentedrone and the other 5 carbon phens are not available yet so i would like to postulate that they have a higher tropane dri affinity based on subJective effects.
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N&PD Moderators: Skorpio
tropane dri
- Thread starter Nexus298
- Start date
ebola?
Bluelight Crew
I'm sorry, I don't really understand your question. Tropane is just a particular functional group found in several cocaine like stimulants, not an active drug. Eg, most of the RTI-series are phenyltropanes (while cocaine itself is just a tropane, with an ester linking the phenyl group). What is "tropane dri affinity"? Affinity for monoamine transporters determines a large proportion of the effects of numerous stimulants.
It is scarce. The dopamine receptor evolved in concert with its endogenous ligand, while other potential endogenous ligands did not. One exception might be binding affinities of DMT at some 5ht receptor subtypes, but DMT is only a partial agonist there and might not even act as a neurotransmitter.
ebolaendotropic
Bluelight Crew
- Joined
- Feb 14, 2012
- Messages
- 1,140
I'm a bit confused by what you're asking. DRI means dopamine reuptake inhibitor, it describes drugs like cocaine and methylphenidate (ritalin). Maybe you mean DAT (dopamine transporter)?
tweex
Bluelighter
Yeah, I think what he's after is sort of stuff like this: http://www.ncbi.nlm.nih.gov/pubmed/8057273
Read the citations and cited work for hours and hours of DRI-related entertainment....
sekio
Bluelight Crew
If you're looking for affinity data, try searching Pubmed and Google.
Here's some to get you started.
From a paper on 'bath salts', the affinities for MDPV:
And a Big Ol' Wikipedia Data Dump.
Most of these compounds had their affinities known before people started making them.... that was why they were selected as "research chemicals". Some enterprising young chemist looked in the med chemistry journals and picked the stimulants with the tightest DAT binding.....
ebola?
Bluelight Crew
Am I confused, or do these data suggest that MDPV functions as a releaser?
ebola
Poodles!
Bluelighter
I think you're correct. This is the first time I've seen any data on MDPV monoamine uptake (never mind release), and all I can say is that is quite a lot of dopamine...188thStreet
Greenlighter
Lower numbers mean higher binding, correct?
sekio
Bluelight Crew
Given the Emax is something like 24%, I don't think it's a very effective releaser... nobody considers cocaine a releaser either.
Lower numbers = higher affinity, yes.
ebola?
Bluelight Crew
Ah. What does this suggest about interpretation of EC50 values in the absence of %Emax data?
ebola