ok - here i am back with the information...
just to give (a little) background... i hit out with my flatmate to parties all the time... so, this isn't just a sideline opinion... we live by these rules and this info... BUT - that's our personal choice to do so with what is, essentially, very early research findings... BUT (again) - she is one of the foremost young MDMA researchers in the world, so...
"there's evidence from researchers such as Boot et al (2000, Lancet journal) that suggests that stacking is one of the best ways to potentiate neurotoxicity... there is no evidence to say 3 bikkies in humans is better at once (obviously), but when you get into higher doses, say 10 mg/kg (3 bikkies probably) then it is best to have 30 mg/kg than three lots of 10 over 48 hours for example..."
BUT - i just want to put a big fuck-off disclaimer here as well. This is all speculative - and, the best empirical data can only be obtained from *animal* research.
IF YOU WANT TO MINIMISE NEUROTOXICITY, MINIMISE INTAKE. (and use 5htp etc).
Get informed, but ultimately, the choice comes down to the individual. To quote Hunter S. Thompson,
"Buy the ticket - Take the Ride".
Please think and play safe.
bD