• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe |

Triple C's + wellbutrin

NarcoticNinja

NarcoticNinja

Greenlighter
Joined
Apr 27, 2011
Messages
14
Okay, so I was thinking of taking four Triple C pills (30mg DXM + 4mg CPM), plus one 30mg wellbutrin pill. From what I understand, both DXM and CPM are metabolized by the CYP2D6 enzyme, which wellbutrin inhibits.

Now, under normal circumstances, wellbutrin seems to double (or, at max, triple) the effects of DXM for me (taking 60mg DXM with a wellbutrin pill, for example, will feel like a low first-plat trip if I have no tolerance, and I don't), but in theory, throwing CPM into the mix will cause an even more powerful reaction. The idea is that these drugs will all synergize and fuck my fucking shit up, because my friend only gave me four pills, and I would rather spend my own money on scheduled drugs.

According to this site, CPM has an LD50 of 130mg/kg in mice. Even if I aim on the safe aide and assume that the LD50 in humans is 100mg/kg, I, as a 125 pound guy, would have to take a fuckton of a lot more than four pills, even considering the DXM and wellbutrin, before I'd die. I am not a medical professional, though, so can anyone shed some light on my assumptions here?

And before anyone tells me about how I shouldn't be doing CCC's and "if you can't get a real drug like LSD or shrooms, at least buy DXM-only robogels, you fucking loser": I can, in fact, get both LSD and shrooms. I am an experienced DXM tripper and have never tried CCC's before in my life. I specifically want to try CCC's because I hear that CPM adds a slight deliriant effect to the DXM experience. I probably won't do it more than once.

Also, I am pretty hellbent on trying this combination, and a simple "don't do it man you'll bleed out your rectum" answer will not deter me, although facts and logic might. I know that this has the potential to be dangerous, but I don't think that it will be at the doses I'm taking. If anyone does have the facts and logic to back up the notion that this will likely kill me, please do share (that's why I'm asking!), but I really, really don't think that it will. I just wanna be on the safe side.

Finally, will tobacco, weed, or buspar (which is not all that psychoactive, but kills my trip anxiety) interact with this combo at all?
 
You'll be fine.
You sound like a milder version of me in highschool.
From personal experience with numerous variations of this combination I can say with relative certainty that there's no danger.
 
no, DO NOT TAKE THIS COMBO!! the CCCs are unsafe to take ALONE!! i am a huge fan of DXM and i have tried DXM + wellbutrin and the combo was more than unpleasant!! i started to have panic attacks and felt like i was going to have a sezirue!!! if nothing bad happens, you will feel extremely unpleasant!!!

i have done CCCs ONCE in my life and NEVER again will i take them. i had such a bad hangover, it was the WORST hangover i have experienced from any drug i have done in my life, worse than meth comedown, worse than alcohol hangover, worse than crack comedown!!! there is nothing special about it, please do not attempt this combo!!

the reason it is dangerous is because both DXM and chlorphenamine are SSRIs and Serotonin Syndrome is very likely to happen!! i am pretty sure i experienced serotonin syndrome from 8 pills because i literally felt like death the next day, it was sooo awful!! it put me off of ever trying dxm again for 4 fucking years thats how bad it was. i rediscovered DXM 3-4 after that experienced and i absolutely loved DXM without it.

omg, if u want to try CCCs then DEFINITELY do not take wellbutrin. you have been warned bro, i cant help but say i told you so if you hate yourself for the next 24 hrs. wtf are u trying to gain from adding wellbutrin to the mix bro?? i dont understand.


i LOVE LOVE LOVE weed on dxm, tobacco is better on DXM than sober too, and im sure buspar would help with some jitters and stimulation. dude i love DXM, but it is sometimes too stimulating for me ALONE, i cant even imagine how bad it would be to take dxm with bupropion. when i did the combo, i only took 60mg DXM with 75mg wellbutrin
 
Also I doubt you'll trip. a psychoactive dose of dxm will overpower the welbutrin unless you're taking nasty doses of bupropion like
 
laCster said:
DO NOT TAKE THIS COMBO!!!!!!111111oneone111
Click to expand...

Okay, but do you have any of those facts and logic and stuff that I asked for? "One time I took 8 pills and it was bad" is not the same thing as "I have a medical degree and/or understand a lot about this subject, I do not recommend it, and here's why."

I don't care if it feels bad. If it sucks, then I learned something. I just don't wanna die or suffer permanent effects.

snazzy_sn said:
Also I doubt you'll trip. a psychoactive dose of dxm will overpower the welbutrin unless you're taking nasty doses of bupropion like
Click to expand...

I am confused. What do you mean? Wellbutrin potentiates DXM, from what I understand and have experienced, and even if DXM did overpower it, wouldn't that mean that I would trip? After all, DXM is what you trip off of, not wellbutrin?
 
i guess you completely read over the part where both DXM and chlorphenamine are SSRIs. the risk for SS is very high and is documented to happen to many individuals.

DXM + wellbutrin is not safe because they both lower your seizure threshold making it more possible for you to experience a seizure. also DXM is a SNRI, and bupropion is a DNRI - both inhibit the reuptake of norepinephrine which will cause very very uncomortable effects. finally, bupropion and DXM are both metabolized by the same heptatic enzyme leading to oversaturation and increased serum levels of one or both drugs meaning you are more likely to experience malevolent side effects.

now, do i believe you will experience any LONGLASTING negative side effects from wellbutrin + dxm? probably not... but the combo will most likely be extremely unpleasant...
 
laCster said:
i guess you completely read over the part where both DXM and chlorphenamine are SSRIs. the risk for SS is very high and is documented to happen to many individuals.

DXM + wellbutrin is not safe because they both lower your seizure threshold making it more possible for you to experience a seizure. also DXM is a SNRI, and bupropion is a DNRI - both inhibit the reuptake of norepinephrine which will cause very very uncomortable effects. finally, bupropion and DXM are both metabolized by the same heptatic enzyme leading to oversaturation and increased serum levels of one or both drugs meaning you are more likely to experience malevolent side effects.

now, do i believe you will experience any LONGLASTING negative side effects from wellbutrin + dxm? probably not... but the combo will most likely be extremely unpleasant...
Click to expand...

I didn't read over it, I just don't think that taking 4 pills is going to cause serotonin syndrome, as I've known people who have taken 12+ without getting serotonin syndrome. That's probably pushing it with CCC's, but still, no serotonin syndrome.

Also, I've combined DXM and wellbutrin many times, and it's a hell of a lot stronger that way, although the trips are admittedly much "darker". I would do it again, though, because it doubles or triples what I get from DXM, and I love my dark trips.

My question is not about DXM + CPM or about wellbutrin + DXM, both of which a fairly well-documented combos that I can find plenty of information on using Google, it's about DXM + CPM + wellbutrin, which I don't know too much about.

Sorry if I sound rude. You just sound like one of my alarmist "OH GOD DON'T DRINK ONE BEER WITH ONE PERCOCET YOU'LL DIE IT SAYS NOT TO ON THE BOTTLE PLEASE DON'T" stoner friends.
 
CPM = SNRI (unknown efficacy, though it has been proven to cause serotonergic toxicity when combined with DXM) | DXM = SRI | Wellbutrin= NDRI

As you can see there are too many S's and N's in that combo. DXM and bupropion can be uncomfortable, but bupropion is contraindicated with chlorpheniramine in supratherapeutic doses (which is also contraindicated with DXM). You really don't want to risk serotonin syndrome (busprione is also serotonergic) or a hypertensive crisis. Even you don't require hospitalization or anything, chances are it'll be exceedingly unpleasant.

Secondly, (competitive) enzyme inhibition:

DXM-> CYP3A4, CYP2D6 | CPM-> CYP3A4, CYP2D6 | Buspirone->CYP3A4 | Bupropion->CYP2D6

They'll not only be potentiating each other's psychological effects, but toxicity as well.

Now, if we remove everything but the DXM, that is desirable to take with CYP3A4 inhbitors (grapefruit juice being the most popular) to increase the formation of DXO relative 3-methoxymorphinan, and increase DXM/DXO plasma levels.

I specifically want to try CCC's because I hear that CPM adds a slight deliriant effect to the DXM experience
Click to expand...

Combine with a different anticholinergic, diphenhydramine may not be the best in your particular scenario due to the other stuff involved, but it'd still be better than CPM. Atropine, Scopolamine, cyclizine, etc. are possibilities.

As for the other things you mention, why would you bother with tobacco when you're on bupropion? Otherwise, that goes fine with DXM and anticholinergics. Cannabis synergizes wonderfully with DXM, mitigating most of the bodyload while kicking the experience up a notch. Herb and deliriants both cause xerostomia, so be prepared.
 
Last edited:
Oops. Well, I already ate it about five minutes ago. Should I make myself puke or just find a trip-sitter and hope for the best?

I found a trip-sitter, so fuck it. I'll post back and let everyone know how horrible it was.
 
Last edited by a moderator:
You'll live, 120mg DXM is a pretty small dose, and the amount of CPM in 4 tabs isn't going to be a major risk.

The major risks are out-of-control potentiation leading to hypertension/seizures/overheating/etc, but even then in most cases of DXM+CPM poisoning, people are aiming for 3rd plateau or more.

You're more likely to have a good time if you keep doses low, which it looks like you've done. I would just roll with it and see what happens, don't worry yourself too much. But don't make a habit of mixing DXM and antidepressants.
 
Also, on the combination side of things: tobacco generally doesn't do much on DXM (antinicotinic effects). Cannabis = very yes. Buspirone... not sure, but I'd play it safe and leavre it out.
 
I've done large doses of CCC's while on wellbutrin. I've seized about 3 times and although this may be speculation, the last time i seized was the last time I was able to get dissociative CEV's.

That being said, any drug that's used to regulate serotonin prescribed by a doctor probably isn't the best thing to be mixing with DXM. However the dosage described is incredibly low so while it may not be smart or healthy, I don't see any major problems with this.
 
You must log in or register to reply here.
Top