treatment resistant persistent opiate withdrawal

[Bucklecroft Rudy]

This is an opiate addicts worst nightmare. For the past year or so ive been experiencing gooseflesh and cold flashes continually these are the symptoms which break me during wd's and they just dont give in. I upped my pod tea dose recently since I assumed tolerance was at work but still my skin is extremely sensitive to cold and reacts at the least sign of it. During withdrawal it goes wild and continues long after all other symptoms have subsided. Im certain its opiate related since dosing does mitigate it somewhat but it simply returns.
I believe that its related to adrenaline. Opiates reduce adrenaline production which is responsible for the reaction im having but somehow I seem to have developed hyper tolerance to that effect. An adrenergic antagonist could help no?

 

[basement_shaman]

Have you considered seeing your own doctor about this? I don't find it feasible to start experimenting with adrenergic antagonists by yourself. In fact, according to personal experience with the adrenergic antagonist mirtazepine, this doesn't make you feel any less cold. But then again I wasn't going through any opiate WDs at the time (or at any other time for that matter) so it may be that it only has this effect when actually experiencing WDs.

 

[ProducedRaw]

If your adrenaline receptors are over-sensitive, and we know that agonising a receptor will cause it to adapt and become less sensitive, why not just overload it with a known adrenaline releasing agent, like caffeine?

 

[Coolwhip]

I think that isn't a bad idea, you would be very uncomfortable for the first few days though. An adrenergic antagonist would give immediate relief, but could make the problem worse.

 

[Bucklecroft Rudy]

Could cigarettes be the ultimate cause. I know that they cause adrenaline to be released (which if so would have desensitised the receptors already) and the issues began around the time I started smoking.

 

[negrogesic]

Have you ever taken clonidine in the past, and if so how did you respond? Or to be more direct, what treatment avenues have you explored that have rendered you 'treatment resistant'?

How many times do you drink the tea and at what dose (grams, assuming the decoction is prepared using dried pod capsules)? How long after drinking the tea do you being to feel this tactile hypersensitivity? For example, say you drank the tea at say 7am, then worked from 9am-5pm; at what point would the hypersensitivity become most prominent? I am simply trying to understand if the issue is a matter of pharmacokinetics. Assuming a once a day dosing schedule, the increase in dose will still have you in withdrawal at roughly the same time, but the rebound/withdrawal symptoms will be more severe.

 

[SpunkySkunk347]

I'm pretty sure I remember reading somewhere that poppy seeds themselves contain toxins (no, not the opiate alkaloids, but something else in the seed matter is inherently toxic/carcinogenic).
And if you are making tea out of THOUSANDS of poppy seeds on a daily basis, then well, the toxins could be building up in your system.
My advice: get to a doctor -- or at very least switch to a different opiate or check yourself into a methadone clinic.

 

[negrogesic]

The discussion pertained to poppy pod tea. I cant even recall a case in which a serious opiate addiction was formed using solely poppy seeds, but I am sure some reports exist [insert freak poppy seed OD here]…