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Trazodone more potent with.. Food?

W

Westmount

Greenlighter
Joined
Sep 21, 2008
Messages
17
Location
Montreal, Canada
As far as i know, med metabolism is always slowed when taken with food.

But why is trazodone more effective when taken with a snack?!!

I just dont find any advanced explication.
 
Because what you know is wrong. Drug metabolism is actually almost always sped up when ingested orally after a small meal. The food increases the rate of absorption for material in the stomach thus the drug reaches the blood stream faster, may be more bioavailable, and certainly results in higher peak plasma levels.

Several drugs are absolutely infamous for this such as oxycodone being much more BA after a small fatty meal. The one prominent exception I can think of is alcohol, this is probably because it is absorbed from the upper intestinal tract where the presence of food can interfere with absorption of large amounts of liquid by reducing surface area of the intestine in contact with the alcohol.
 
A slice of toast at 6:00 am .

A 3 mg diazepan tab at 6:30 ish

A cup of tea with your favorite tipple - Jamiesons Irish for me :)


perfect - a joint as soon as possible

I stopped the trazadone - OK I don't sleep - still better
 
Zolpidem, Zopiclone, and Zaleplon don't absorb NEARLY as well after a fatty meal. On an empty stomach I go from zero to fucking thrashed in about 10 minutes. With a fatty meal, there's some chance nothing will ever happen, or it'll take at least 45 minutes to an hour.
 
The Monkey Mantra said:
Zolpidem, Zopiclone, and Zaleplon don't absorb NEARLY as well after a fatty meal. On an empty stomach I go from zero to fucking thrashed in about 10 minutes. With a fatty meal, there's some chance nothing will ever happen, or it'll take at least 45 minutes to an hour.
Click to expand...

Could have to do with blood sugar levels, you feel more energized after a meal than on an empty stomach and Zolpidem would work against that. Then again the half life of Zolpidem is far longer than the time it takes for you to digest a meal.
 
Zolpidem's half-life is extremely short (around 2hrs). Much, much shorter than it takes for a meal to be digested.
 
Food reduces the BA of zopiclone so it might be the same for other z hypnotics. The absorbtion of some drugs is increased by food but with other drugs it's decreased.

Gabapentin is a good example of a drug that has it's BA increased with food though only by 15% or so. Zopiclone on the other hand does not absorb nearly as well with food especially a fatty meal.
 
Oral ingestion of drugs is so complicated, surface area, enzyme action, first pass metabolism etc etc. Does anyone have any idea where I could more or less just get a reference index of how drugs are orally processed? I'm asking for a link to a quick reference sheet really.
 
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