Transdermal psychs

[jari]

I have been ingesting the DMSO (90% DMSO) with liquid morphine, and it seems to work about three times better than alone, allowing me to take less medication to control my pain...however, I haven't yet had any success with the DMSO in any way on the skin. I read that in chronic pain patients it can take weeks to work, and also that the effect is cumulative.

Anyone have any ideas of transdermal application of the DMSO and liquid morphine? I have been using very weak amounts (watered down) of the morphine for fear that I would get too much, perhaps this is why it is not working. Or maybe it just takes time.

Also, would it make any difference if I placed the DMSO over a painful area alone, or with the morphine mixture? As opposed to placing it anywhere the skin in relatively thin, the objective being to get it into the bloodstream?

 

[jari]

I know this is under psychs, but I don't see anywhere better to place these questions, if anyone has any suggestions ?

 

[theWorldWithin]

Being fairly weak on a mg for mg basis I do not think morphine is an ideal candidate for transdermal delivery. Generally only the ultra potent opiods are viable solutions. Not to mention this is going to require pure product regardless of the compound which I doubt you can acquire reasonably.

 

[urbantakeover]

If I remember correctly DMSO is really not an ideal candidate if you want to go transdermal, it has a fairly low absorbtion rate of like 20% (if I remember correctly), also the 25-nb(what ever the name is) class of drugs is not an ideal candidate for transdermal Route either due to it's high mol mass, in order for it to penitrate the membrane of the skin it must be below 500 mol, the 25-c I looked up was around 470ish leading it to be a bit on the bigger side. The lower the molecular mass the better the absorbtion. On top of that even the best medical transdermals have only a 60% absorbtion rate through the skin so it would almost have to be double the dose it would normally be IV. This leads to great result for products with shit oral avaliblity, but good iv avalibility. This is why many steroid users look to transdermals as a method around pinning. While they use up more raw material they get great results without using a needle. In products already marketed as transdermal they rate the dose on what will go through the skin not on what is actually present on the patch.
This was written from my I-pod so please bare with the crappy spelling and formatting

 

[PandaGun]

very interesting chemical, i suppose you could put some on a blotter & hold that under your tongue... also from what i've read i didn't think it was active below 400-500mcg, so you might have not used enough. Haven't heard anything about rectal administration.

Put it in to a solution measure out the dose, I'd say to start off with 300-375mcg, then squirt it up your nose and try and not bring it back down as drip back.