• BASIC DRUG
    DISCUSSION
    Welcome to Bluelight!
    Posting Rules Bluelight Rules
    Benzo Chart Opioids Chart
    Drug Terms Need Help??
    Drugs 101 Brain & Addiction
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Tramadol

Not looking it up but afaik the conversion to the Opioid o-DSMT.
Happens in the liver, so take oral, don t think you can snort em either.

Its not like o-DSMT though, way dirtier with a limit after which,
the risk for a seizure excist s. Just that you are aware !
 
Oral. It has high bioavailability, which Is even higher after few doses. Tramadol has also prolonged half-life, o-DSMT too after few doses.
What do u want to use tramadol for if i may ask ?
 
Isn't tramadol a prodrug like codeine? It's mainly first-pass metabolism by the liver that produces the active O-DMT.

I SUSPECT one of the major selling points of tramadol might have been that it was a prodrug thus not liable to parentheral administration.

I just tell people to be careful with the stuff. The product is a mixture of two enantiomers. One is an opiod, the other monkeys around with monoamines. It appears that the latter is what makes it more dangerous in overdose than things like codeine.

I'm still mightly surprised that no vendor has resolved the opioid enantiomer and performed the O-demethylation on that. I read a paper in which the single enantiomer of O-DMT was compared to tramadol and not only was it something like eight times more potent, it was also far less toxic.
 
4DQSAR said:
Isn't tramadol a prodrug like codeine? It's mainly first-pass metabolism by the liver that produces the active O-DMT.

I SUSPECT one of the major selling points of tramadol might have been that it was a prodrug thus not liable to parentheral administration.

I just tell people to be careful with the stuff. The product is a mixture of two enantiomers. One is an opiod, the other monkeys around with monoamines. It appears that the latter is what makes it more dangerous in overdose than things like codeine.

I'm still mightly surprised that no vendor has resolved the opioid enantiomer and performed the O-demethylation on that. I read a paper in which the single enantiomer of O-DMT was compared to tramadol and not only was it something like eight times more potent, it was also far less toxic.
Click to expand...

Yes it's a prodrug so the only way you can take it is orally. If you take it any other way it's a complete waste. And yeah it works the exact same way as Codeine. Interestingly the only drugs that I can think of that doesn't have any metabolites are the Gabapentinoids like Gabapentin and Pregabalin.
 
4DQSAR said:
Isn't tramadol a prodrug like codeine? It's mainly first-pass metabolism by the liver that produces the active O-DMT.

I SUSPECT one of the major selling points of tramadol might have been that it was a prodrug thus not liable to parentheral administration.

I just tell people to be careful with the stuff. The product is a mixture of two enantiomers. One is an opiod, the other monkeys around with monoamines. It appears that the latter is what makes it more dangerous in overdose than things like codeine.

I'm still mightly surprised that no vendor has resolved the opioid enantiomer and performed the O-demethylation on that. I read a paper in which the single enantiomer of O-DMT was compared to tramadol and not only was it something like eight times more potent, it was also far less toxic.
Click to expand...
Well pro-drug not really, even blocking Mu-receptor s would yield effect s,
on all the other neuro-system s. Tramadol without Mu, sound s as torture.

Which your warning for if may ask, its early morning. Tramadol or o-DSMT ?
Tramadol obvious more risky, above 400 mg seizure risk.
Not to mention interacting with other Serotinergic s, myself Tramadol i d decline.
What a fucked dirty neurtransmitter activating factory.
even made my female a feeling less creature, inc no sexdrive. .

o-DSMT also has 2 enantiomer s. The one responseable for the NRI action.
Get that seperated out and it would be a perfect Opiod, the NRI keeps me awake.
 
emkee_reinvented said:
Well pro-drug not really, even blocking Mu-receptor s would yield effect s,
on all the other neuro-system s. Tramadol without Mu, sound s as torture.

Which your warning for if may ask, its early morning. Tramadol or o-DSMT ?
Tramadol obvious more risky, above 400 mg seizure risk.
Not to mention interacting with other Serotinergic s, myself Tramadol i d decline.
What a fucked dirty neurtransmitter activating factory.
even made my female a feeling less creature, inc no sexdrive. .

o-DSMT also has 2 enantiomer s. The one responseable for the NRI action.
Get that seperated out and it would be a perfect Opiod, the NRI keeps me awake.
Click to expand...

Yeah the SNRI properties of Tramadol ruin it's opioid activity. I think it feels "dirty".
 
evo4ever said:
Yes it's a prodrug so the only way you can take it is orally. If you take it any other way it's a complete waste. And yeah it works the exact same way as Codeine. Interestingly the only drugs that I can think of that doesn't have any metabolites are the Gabapentinoids like Gabapentin and Pregabalin.
Click to expand...

Similar but not the same. Unlike codeine, tramadol is a a mixure of two enantimomers. One is a prodrug that is metabolized into an opioid, the other is active but not as an opioid but rather as a monoamine modulator. As I noted, it's this latter enantiomer that makes tramadol far more toxic in overdose than codeine.
 
  • Like
Reactions: PPE
You must log in or register to reply here.
Top