tricomb
Bluelight Crew
Exactly, when your taking a medication that takes 6-8 weeks to take effect, logically, skipping a few doses wouldn't do much.
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OD Moderators: Keif’ Richards | Tryptamino
Opioids Tramadol?
- Thread starter Pineappleexpress42
- Start date
ErgicMergic
Bluelighter
^ Tramadol and gabapentin share a similar synergy
Tramadol is actually quite nice on its own, granted that you take less than 150mg per day. I would recommend taking the whole dose at once to feel the stimulant effect, and a solid, "clean" serotonin release instead of a bunch of mini-releases caused by staggering your dosage.
Also, eat 20-30 minutes after taking it. This drastically cuts down on serotonin/stimulant naseau caused by tramadol's "dirty" mechanism of action.
Tramadol is actually quite nice on its own, granted that you take less than 150mg per day. I would recommend taking the whole dose at once to feel the stimulant effect, and a solid, "clean" serotonin release instead of a bunch of mini-releases caused by staggering your dosage.
Also, eat 20-30 minutes after taking it. This drastically cuts down on serotonin/stimulant naseau caused by tramadol's "dirty" mechanism of action.
Pineappleexpress42
Bluelighter
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Ok well, I relize this can cause bad effects but I gradually increased and am up to 150 mgs with no I'll effects. How likely is seritonin syndrome to be deadly?
Coraline
Bluelight Crew
That really depends on all the meds you are taking. Celexa and tramadol have a interaction that lists seritonin syndrone. So beyond this I can not give you advice.
If the dr gave you tramadol while knowing you take celexa follow his/ her advice. Also if you ever have any concerns with your medication you can always call a pharmacy even ones you don't use and ask them questions. They should be able to give you more detailed answers.
I can not take tramadol. It gives me horrible headaches that last +3 days. I also can not take medications that mess with my noreperniphrine receptors. I have bad reactions.
Seritonin syndrone is a crisis situation. If you think you are having it go to the ER right away.
If the dr gave you tramadol while knowing you take celexa follow his/ her advice. Also if you ever have any concerns with your medication you can always call a pharmacy even ones you don't use and ask them questions. They should be able to give you more detailed answers.
I can not take tramadol. It gives me horrible headaches that last +3 days. I also can not take medications that mess with my noreperniphrine receptors. I have bad reactions.
Seritonin syndrone is a crisis situation. If you think you are having it go to the ER right away.
Pineappleexpress42
Bluelighter
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Ok, I think I'm fine. If I stop taking celexa for 7 days will it be completely out of my system because it's half life is 36 hours. Then it would be safer to take tramadol?
So would I be good to use them then?
Anyone?
So would I be good to use them then?
Anyone?
Last edited by a moderator:
tricomb
Bluelight Crew
For all anti-depressant related interactions, the rule of thumb is 2 weeks / 14 days. I'm not sure why anyone would want to mess with their anti-depressants so much just to take tramadol...
ErgicMergic
Bluelighter
Agreed. O-Desmethyltramdol has a half life of 9 hours, so if you have enough copies of CYP2D6 enzymes in your liver, then it is an amazingly effective drug to taper off of weaker opioids, such as hydro, kratom, and codeine.
It definitely builds up in your bloodstream with repeated dosing, which is why I avoid using relatively large (100-150mg) doses for more than 3 days in a row.
When using tramadol in a manner analaogous to a short Suboxone taper, it takes me at least 1.5-2 days to even get a runny nose. I use 75-100mg on day 1, 50mg day 2, and 25mg day 3-4.
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Pineappleexpress42
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Ok well I went cold turkey celexa for the past 3 days not too bad w/d. I also have other reasons to quit celexa not just for tramadol/dxm/xtc. I've taken 225mgs of tramadol, along with 300 mgs gabipentin and no sezuires or bad effects. I know that was a high dose but I figured I could do it without seritonin syndrome. Thanks everyone for advice!
Pineappleexpress42
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I took a total of 250 mgs of tramadol and 1200 mgs of gabipentin. It was about from 5 hours ago up to 2 hours ago when I took the gabipentin. Time is so slow I feel like I'm in a dream. By far the highest I've ever been. Is it safe to sleep or should I stay up and wait it out?
tricomb
Bluelight Crew
^There's no way that any of us can know the answer to that.
Pineappleexpress42
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That's what I kinda figured, well I went to bed and I'm fine. I'll just lower the doses next time to be safe.
Like everyone else has said, you are on an SSRI, and tramadol has an SNRI action to it, so no the combination is not safe.
Some more related reading for the OP on how other drugs interact with the antidepressant you're on.
Some more related reading for the OP on how other drugs interact with the antidepressant you're on.
SSRIs
Mechanism of Action
SSRIs (Selective Serotonin Reuptake Inhibitors) work by selectively inhibiting the reuptake of serotonin. Thus, more serotonin remains for a longer period of time in the synapses. Although the different SSRIs vary in how effective they are at inhibiting 5-HT reuptake, they all do so selectively, and thus they do NOT have a direct (significant) effect on other NTs.
Common Side Effects
Insomnia, sedation (thought not nearly as severe as with the TCAs), tremor, gastronintestinal problems, rashes, sexual dysfunction (decreased libido and difficulty orgasming), acute anxiety.
Metabolism
SSRIs inhibit, to varying degrees, the enzymes CYP1A2, CYP2C19, CYP3A4 and CYP2D6. SSRIs and their metabolites can take a long time to completely leave the body. The issue with SSRIs is that in addition to the immediate effect they have on the brain, they also alter the brain in such a way that it takes some time after going off the SSRI for the brain to return to its normal configuration. How much a person's brain has been altered (and thus how long it will take for their brain to become normal again, and thus able to feel the full effects of MDMA), depends on the dose of the SSRI the person was taking, as well as the length of time the person was taking it for. So you can see, the time the person needs to be off an SSRI in order to, say, roll effectively will vary greatly from person to person. And that's not even taking into account a person's unique brain chemistry and metabolism.
Recreational Drug Interactions
Alcohol, GHB (and related substances), Benzos (Xanax, Valium, Klonopin etc), Opiates (Heroin, Codeine, Vicodin, Oxy etc), Barbituates, Ketamine: All of these drugs can be safely combined with SSRIs. You might be slightly more sensitive to alcohol, benzos, and barbituates (i.e.,they might fuck you up more than usual), otherwise, you should experience the drug as you would normally. Some people find that ketamine and opiates do not affect them as strongly.
DXM (Dextromethorphan, Robotussin): This can be a very DANGEROUS combination! Do not take DXM and SSRIs together! Combining DXM with an SSRI can lead to too much serotonin in your brain, which can cause the potentially FATAL serotonin syndrome.
MDMA/Ecstasy (includes MDA, MDEA etc): It is NOT POSSIBLE TO ROLL while taking an SSRI! It is a COMPLETE and UTTER WASTE OF YOUR MONEY! Basically, SSRIs 'block' the part of your brain where the MDMA needs to go in order to get you high; and since MDMA can't get in there, you won't be able to get high. You might experience some weak 'speedy' effects from high doses of MDMA, but you will not be able to truly 'roll'.
Do NOT stop taking your SSRI so that you can roll. First of all, even if you stop taking it for a few days, it is unlikely that you will fully be able to roll. It takes much longer than a few days for all the SSRI (and its metabolites and effects) to leave your body (read above under 'metabolism'). Second, you can get VERY SICK (withdrawal symptoms, depression, etc) if you stop taking your medicine. I strongly suggest that you give up rolling while you are taking an SSRI.
Amphetamines (Methamphetamine, Adderall, Dexedrine), Ritalin (methylphenidate), Cocaine, 4-MAr (4-methylaminorex, sometimes called 'ice' or 'euphoria'): The effects of these drugs on someone taking an SSRI will not be significantly different. With the amphetamines, especially methamphetamine, there will be less 'loveyness' but overall, the high will remain unchanged. This is a safe combination overall, and you should still be able to get high from these stimulants while on an SSRI.
Hallucinogens (LSD/Acid, psilocybin/Shrooms, Tryptamines, 2-ct-2,DPT, DMT etc, Salvia): These drugs can be safely combined with the SSRIs. Most people report that they need to take MORE of a hallucinogen to get normal effects. Thus, if you are taking an SSRI, you will probably need more of the drug to reach threshold effects. Some people find that they need to take more LSD, but that shrooms affect them normally. So be careful to start at a normal dose and only take more if you find that you need to.
NOTE: Do not take 'ayahuasca' while on an SSRI. Do not combine SSRIs with any kind of MAOI, such as harmaline.(Source)
Mechanism of Action
SSRIs (Selective Serotonin Reuptake Inhibitors) work by selectively inhibiting the reuptake of serotonin. Thus, more serotonin remains for a longer period of time in the synapses. Although the different SSRIs vary in how effective they are at inhibiting 5-HT reuptake, they all do so selectively, and thus they do NOT have a direct (significant) effect on other NTs.
Common Side Effects
Insomnia, sedation (thought not nearly as severe as with the TCAs), tremor, gastronintestinal problems, rashes, sexual dysfunction (decreased libido and difficulty orgasming), acute anxiety.
Metabolism
SSRIs inhibit, to varying degrees, the enzymes CYP1A2, CYP2C19, CYP3A4 and CYP2D6. SSRIs and their metabolites can take a long time to completely leave the body. The issue with SSRIs is that in addition to the immediate effect they have on the brain, they also alter the brain in such a way that it takes some time after going off the SSRI for the brain to return to its normal configuration. How much a person's brain has been altered (and thus how long it will take for their brain to become normal again, and thus able to feel the full effects of MDMA), depends on the dose of the SSRI the person was taking, as well as the length of time the person was taking it for. So you can see, the time the person needs to be off an SSRI in order to, say, roll effectively will vary greatly from person to person. And that's not even taking into account a person's unique brain chemistry and metabolism.
Recreational Drug Interactions
Alcohol, GHB (and related substances), Benzos (Xanax, Valium, Klonopin etc), Opiates (Heroin, Codeine, Vicodin, Oxy etc), Barbituates, Ketamine: All of these drugs can be safely combined with SSRIs. You might be slightly more sensitive to alcohol, benzos, and barbituates (i.e.,they might fuck you up more than usual), otherwise, you should experience the drug as you would normally. Some people find that ketamine and opiates do not affect them as strongly.
DXM (Dextromethorphan, Robotussin): This can be a very DANGEROUS combination! Do not take DXM and SSRIs together! Combining DXM with an SSRI can lead to too much serotonin in your brain, which can cause the potentially FATAL serotonin syndrome.
MDMA/Ecstasy (includes MDA, MDEA etc): It is NOT POSSIBLE TO ROLL while taking an SSRI! It is a COMPLETE and UTTER WASTE OF YOUR MONEY! Basically, SSRIs 'block' the part of your brain where the MDMA needs to go in order to get you high; and since MDMA can't get in there, you won't be able to get high. You might experience some weak 'speedy' effects from high doses of MDMA, but you will not be able to truly 'roll'.
Do NOT stop taking your SSRI so that you can roll. First of all, even if you stop taking it for a few days, it is unlikely that you will fully be able to roll. It takes much longer than a few days for all the SSRI (and its metabolites and effects) to leave your body (read above under 'metabolism'). Second, you can get VERY SICK (withdrawal symptoms, depression, etc) if you stop taking your medicine. I strongly suggest that you give up rolling while you are taking an SSRI.
Amphetamines (Methamphetamine, Adderall, Dexedrine), Ritalin (methylphenidate), Cocaine, 4-MAr (4-methylaminorex, sometimes called 'ice' or 'euphoria'): The effects of these drugs on someone taking an SSRI will not be significantly different. With the amphetamines, especially methamphetamine, there will be less 'loveyness' but overall, the high will remain unchanged. This is a safe combination overall, and you should still be able to get high from these stimulants while on an SSRI.
Hallucinogens (LSD/Acid, psilocybin/Shrooms, Tryptamines, 2-ct-2,DPT, DMT etc, Salvia): These drugs can be safely combined with the SSRIs. Most people report that they need to take MORE of a hallucinogen to get normal effects. Thus, if you are taking an SSRI, you will probably need more of the drug to reach threshold effects. Some people find that they need to take more LSD, but that shrooms affect them normally. So be careful to start at a normal dose and only take more if you find that you need to.
NOTE: Do not take 'ayahuasca' while on an SSRI. Do not combine SSRIs with any kind of MAOI, such as harmaline.(Source)
Pineappleexpress42
Bluelighter
- Joined
- Apr 26, 2012
- Messages
- 183
Yes I understand that but I figured with such a low dose of celexa 20mgs and went cold turkey 4 days ago with combo of gabbypentin (to prevent sezuires) I figured I was safe aslong as I slowly increased dose. Thanks for the link/info.