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  • EADD Moderators: Pissed_and_messed | Shinji Ikari

Tramadol

I think using 1g daily for a few weeks is enough to start getting WD when you run out.

I am quite "hard headed" though. I would not recommend this dosage to children.
 
Note of caution:

Tramadol has adverse reactions with quite a few drugs, but mosrt importantly, drugs that are serotonin reuptake inhibitors; some, but all of which include, ketamine, methoxetamine, MDMA and other entactogens, tricyclic antidepressants & of course MAOIs. Of special note are the SSRI antidepressants, which also inhibit the metabolism of tramadol, making them doubly dangerous (this combo has lead to fatal cases of serotonin syndrome)

If you're lucky enough to obtain some of the active metabolite, O-desmethyltramadol, then it's not a problem as it has no serotonogic activity (as well as 200x the affinity for the mu opiate receptor, making it much more 'fun'!), It still has noradrenaline reuptake inhibition though, so some caution is still needed
 
fastandbulbous said:
Note of caution:

Tramadol has adverse reactions with quite a few drugs, but mosrt importantly, drugs that are serotonin reuptake inhibitors; some, but all of which include, ketamine, methoxetamine, MDMA and other entactogens, tricyclic antidepressants & of course MAOIs. Of special note are the SSRI antidepressants, which also inhibit the metabolism of tramadol, making them doubly dangerous (this combo has lead to fatal cases of serotonin syndrome)

If you're lucky enough to obtain some of the active metabolite, O-desmethyltramadol, then it's not a problem as it has no serotonogic activity (as well as 200x the affinity for the mu opiate receptor, making it much more 'fun'!), It still has noradrenaline reuptake inhibition though, so some caution is still needed
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This suggests both tramadol and O-desmethyltramadol "inhibit NMDA receptors", do you see this as an issue?

Also, which combinations (with commonly used susbtances) do you see as being an issue with the NARI effect of O-desmethyltramadol?

I'm particularly interested to find out what stimulants would be relatively safe to use with the O-desmethyltramadol. I like it for several reasons, one of which is how it fixes my neck pain, but it makes me oh so very lazy...

[edit] actually I just found a low dose (10mg plugged) of methoxetamine makes the neck pain much more bearable, and perks me up a bit. Still interested to know about O-desmethyltramadol/stim combos though. My stim options are, I suppose, methiopropamine and camfetamine. I find 20mg doses of MPA quite acceptable for a no-frills stim - never had any unpleasant side-effects.
 
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I went through a ~10 day period of indulging in small but regular alternating bumps of both mpa and o-desmethyltramadol throughout the day.. the combo is nice, I like the alternate dosing and the way the stimulating and relaxing effects mix. On the 10th day I abstained and after ~8 hours of thinking I'd got a away scott free, had what I can only assume were mild opitate WDs.. felt shit for next 12 hours, eventually booze and etizolam sorted it a bit though. It was enough to give me a warning that even fairly forgiving opiates/opioids are to be treated with caution, especially with daily use even over a few days.
 
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Skyline_GTR said:
I went through a ~10 day period of indulging in small but regular alternating bumps of both mpa and o-desmethyltramadol throughout the day.. the combo is nice, I like the alternate dosing and the way the stimulating and relaxing effects mix. On the 10th day I abstained and after ~8 hours of thinking I'd got a away scott free, had what I can only assume were mild opitate WDs.. felt shit for next 12 hours, booze sorted it a bit though. It was enough to give me a warning that even fairly forgiving opiates/opioids are to be treated with caution, especially with daily use even over a few days.
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Great info, thanks! And yeah, I'm wary of opi*s and I won't be making it a daily thing.
 
I've been on em for years now, along with Arcoxia (after the Vioxx was pulled from the shelves, and a couple of nasty disease-modifying drugs (bad immunosuppressant side effects from them bastards...)

Was just a bit worried reading some of the comments on this thread about interactions with recreationals..

I tend to not take any of the prescription meds on the same day as I'm partying, but what are the increased risks of generally having 'em in your system?... like, I'm still not dead, so obviously I'm not doing too bad, but I suppose I'd be better to know the true risks...

As for Tramadol, I don't really get any psychoactive effects from 300mg a day - what I do get is a horrid restless-legs dealie if I don't take 'em for a day or so...
 
havent done trams in a while, used to love it.

350-400mg used to give me a speed like effect but relaxed at the same time,

then 150mg plus top ups throughout the day gave me more opiate like effects.

Will have to try and get some more some day.
 
Hello. I'm one of those lucky sods who gets a buzz off 50mg of Tramadol. Could anybody give me some info on mixing low doses of Tram(150mg) with Dexedrine low dosage (30mg). I have a feeling it might not be a good idea but I've got an opportunity and I hate to waste opportunities.;) They seem few and far between at the moment.
 
Thirteen666 said:
Quick question: Can I mix I.V. tramadol with 3-FMC (also i.v.)?
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I wouldn't dream of it - Seizures are a massive possibility.

DonQuixote said:
Hello. I'm one of those lucky sods who gets a buzz off 50mg of Tramadol. Could anybody give me some info on mixing low doses of Tram(150mg) with Dexedrine low dosage (30mg). I have a feeling it might not be a good idea but I've got an opportunity and I hate to waste opportunities.;) They seem few and far between at the moment.
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Again, Seizures Seizures Seizures!
Mixing Tramadol with any stimulant is a bad idea. Any other Opiate that doesn't act on any other receptor other than µ-Opioid receptors would be pretty much fine to mix with Stims, but definitely not Tramadol.
 
Thanks for that monstanoodle. Last night didn't bother in the end. But Oh! But Oh! The temptation when things are going shittly and you feel like a bit of escape.
 
I actually took tramadol quite a few times, when I wanted to get some sleep, after speed. Nothing bad ever happened, but I certainly wouldn't do it now. Even though speed doesn't work much on serotonin, I wouldn't risk it.
 
After reading this thread don't think i'll be going near tramadol. Been offered it a few times lately but seems overpriced and sounds like you'd be better with DHC or valium. The risk of seratonin syndrome and the way the drug works puts me right off.

I wouldn't mind trying oxycontin though.
 
i'm on 500 mgs of tramadol and will ingest in few minutes 300mgs of pure codeine fosfate.
How much time you think i should wait from one drug to the other?
Please help.
 
At what time did you take the tramadol? You should be able to take the codeine anytime really. Just be sure not to drink a lot of alcohol and you'll be OK.
 
^ yeah should be okay.. but if in doubt always wise to err on the side of caution! Be aware that you shouldn't really have more than 400mg of tramadol in 24 hours though.. there's a risk of seizures (as has been mentioned lots before just wanted to reiterate!) 500mg obviously isn't a lot more and most people would be fine but you don't want to find out that you are particularly prone to them..
 
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effie said:
^ yeah should be okay.. but if in doubt always wise to err on the side of caution! Be aware that you shouldn't really have more than 400mg of tramadol in 24 hours though.. there's a risk of seizures (as has been mentioned lots before just wanted to reiterate!) 500mg obviously isn't a lot more and most people would be fine but you don't want to find out that you are particularly prone to them..
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Thanks for the advice. i'm already pretty high on beer, and was planning to take mo 500mhs od tramadol. won't anymore. i'll stick to codeine, cylobenzaprine, klonopins anda alchool.
 
18 minutes since the ingestion of 300mgs af pure codeine fofate. 6 hours after taking 0.5g of tramadol. smoking weed an drinking. if i could stop the time... it would be this way!
 
Yeah I def woudn't take another 500mg.. Go steady on that mix, downers plus other downers plus yet more can be really dangerous. Codeine and tramadol aren't super-strong opiates but that kinda lulls people into a false sense of security sometimes, throwing in a lot of alcohol and benzos might be a bit too much..

Sorry to sound preachy, don't mean to :) Although mixing small amounts of those together can be lush, it really can be a deadly combination. Stay safe :)

edit: haha sam beat me to it!
 
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