Opioids tramadol - thr hidden dangers behind this apparently harmless drug

[BluLait]

I've heard of plenty of people having seizures from tramadol. Is it really that dangerous? Or is this just in high doses?

I just took some tramadol 5 hours ago and I still feel kind of speedy, but in a very weird way. Also... 100mg did SHIT for my wisdom tooth surgery which hurts like hell. Aspirin works better. So what's the deal with this drug? t 100mg it doesn't seem to have any opiate effects at all, just a improves my focus, makes me less irritable.. and that's about it. How can I get the best out of this drug - recreational wise. How long do the effects last? Seems to be a nice substitite for caffeine. Im getting sleepy again. I took 75 mg 6 hours ago and another 25 mg 2 hours ago. Is it safe to redose without having a seizure?

 

[Swimmingdancer]

Tramadol feels different from other opioids, but it can also affect different people differently. About 1 in 10 people don't get as much of the "good" effects but they still can get the negative effects. It is because they have decreased CYP2D6 activity (one of the enzymes which metabolizes Tramadol). If you are not getting analgesia (pain killing) from it and you find aspirin to provide better analgesia you may well be one of these people. Seizures have been reported in people taking above 600mg orally, but that doesn't mean it can't cause seizures in lower doses. There is also an increased risk of seizure from taking Tramadol (even in lower doses) with other drugs/alcohol, if you have a serious health condition or a head injury, or if you have an increased risk for seizures already. Usual starting dose for Tramadol (for acute moderately severe pain) is 25-50mg every 6 hrs not to exceed 300mg a day. Of course some chronic pain patients or recreational users with high tolerances will eventually go higher than that, but I wouldn't recommend it if you don't have a tolerance and the Tramadol doesn't seem to be working for you.

I can't guarantee you won't have a seizure (or any other side effects), but yes I think it should be relatively safe for you to take another 50mg. Most people find they get better effects from staggered dosing as opposed to taking it all at once.

Also do you have regular (IR) Tramadol or Tramadol ER?

ETA: If you think Tramadol is just "a nice substitute for caffeine", stop taking it! Caffeine is much safer.

 

[snazzy_sn]

i don't know the specific answers to most of your questions but i will say this.

about half the people i've talked to think this drug is worthless for recreational purposes and the other half think it's great.

and nobody can really tell you what's safe or what isn't, but if i had to decide i'd say you're good, go ahead and redose.

 

[BluLait]

I just took 25 mg's exactly 1 hour ago. I am feeling a bit woozy. Awkward. What are the signs of an upcoming seizure?

 

[TyLannister]

<I should think before speaking> 25 mg wont throw u into seizures, but you can tell if your starting to have one by feeling dizzy, tremors, seizing, all that fun stuff.

 

[NeighborhoodThreat]

For most people, the dangers of seizure don't really come into play until you get to the 400mg + dosage range.

So no, unless you have other medical conditions or are mixing the tramadol with other drugs, 125mg should be just fine.

 

[BluLait]

I also have some ibuprofen, paracetamol, and about 30 mg of codeine and 100 mg of caffeine in my system. How safe is it to take 50 mg more of this tramadol shit?

I think i have the IR ones because it doesn't say anything else except tramadol hcl 50 mg on the box

 

[lucindalicious]

Hey, new here. I've been taking Tramadol every day now for a couple years. I take anywhere from 8 to 14 50mg pills a day, sometimes more. Obviously this isn't ideal, but I have never had a problem thus far. No seizures, nothing. I started out on a much lower dose and built up to this kind of tolerance over the course of a year.

 

[ChemicalFeelings]

I've been using trammies for a while now and I did the stagger method 50mg every 15-25min up to 200mgs. Really nice effect. Today I tried a new method 50mg oral and then 150mg plugged. Super nice effect. And nope no seizures or even close. Enjoy.

 

[ReversiblePulpitis]

I've had one seizure in my lifetime, and it was tramadol induced. I had been taking it regularly for probably a year prior to the seizure. I dosed with about 300mg over the course of 4 hours. It was the only tramadol I had taken that day, and was the only I was going to take.

I was not aware of the oncoming seizure, I just blacked out and the next thing I knew, I was on the floor getting lifted onto a stretcher for an ambulance ride. Literally one moment I was sitting at the table, and the next was groggy on the floor, not knowing why I instantaneously teleported from the chair to the floor. Scary shit.

 

[BluLait]

When you keep the pill in your mouth, is it normal to numb it a little, or fot it to be a little acidic? It leaves a kind of little numb spot on my tongue.

 

[sekio]

That's normal, it's vasoconstriction caused by the norepinephrine-reuptake blocking effects I'd bet.

 

[ChemicalFeelings]

Mmmmmm...I never get that!

 

[BluLait]

That's normal, it's vasoconstriction caused by the norepinephrine-reuptake blocking effects I'd bet.

The re-uptake pumps are only in the brain. So what you said doesn't make any sense at all.

 

[Tommyboy]

I wouldn't exactly call them "hidden dangers" since it is well documented that high doses can cause seizures. One of the other things that is unique to tramadol compared to most other opioids (other than levorphanol) is that its withdrawal is often worse than expected considering how weak it is, since it is a NMDA-antagonist with SNRI activity. This means that you experience both opioid withdrawal, as well as SNRI withdrawal which has the same symptoms as SSRI discontinuation.

 

[i against i]

why are you taking ibuprofen, paracetamol, codeine, caffeine and tramadol at the same time?

 

[blakmike]

Just like the toxic metabolite buildups that come from meperidine and propoxyphene (same metabolite with both synthetic opiods), I think that chronic heavy doses of this synthetic crap can be nasty.

That goes for the Research Chemical analogue of tramadol too I think.

Methadone, on the other hand is a very nice synthetic, well, and fentanyl can be nice when dosed right.... Come to think of it, I don't know what I'm really talking about.

TL/DR Tramadol, demerol, and darvon are crap.....

 

[BluLait]

why are you taking ibuprofen, paracetamol, codeine, caffeine and tramadol at the same time?

I was at work today, and I had a wisdom tooth removed. Hurts like shit.

Coffee to keep me awake. Tramadol just because... I wanna see what it's like. Nurofen plus (with codeine) and generic paracetamol-codeine - both to help with the immense pain.

 

[tricomb]

I wouldn't exactly call them "hidden dangers" since it is well documented that high doses can cause seizures. One of the other things that is unique to tramadol compared to most other opioids (other than levorphanol) is that its withdrawal is often worse than expected considering how weak it is, since it is a NMDA-antagonist with SNRI activity. This means that you experience both opioid withdrawal, as well as SNRI withdrawal which has the same symptoms as SSRI discontinuation.

^This, no one ever said tramadol was harmless, and the seizure risk is indeed well documented and certainly isn't a hidden danger.

And as for how to tell if you're about to have a seizure? You won't know until it's too late.

 

[helium-4]

in alot of pain situations just taking opioids especially lower doses of opioids will not get rid of all of the pain. taking something like an nsaid with an opioid will make a wolrd of difference. opioids will not take away the inflammatory response. the inflammatory response your body has causes alot of pain on top of the pain signals that the opioids will reduce. combining both will give you the best results if inflammation is a symptom. alot of individuals forget this. also tramadol is not the best opioid/pain killer for general somatic pain. the nmda-antagonism and snri effect (yeah some places say s releaser while others say snri, i personally say snri), with the light selective mu agonism, can help with different types of pain than somatic pain. i know individuals who prefer tramaddol with a nsaid over hydrocodone and an nsaid for their back pain. alot of back pain involve neurological pain which the nmda-antagonism and snri effect have been shown to help these non-nociceptive pain