• BASIC DRUG
    DISCUSSION
    Welcome to Bluelight!
    Posting Rules Bluelight Rules
    Benzo Chart Opioids Chart
    Drug Terms Need Help??
    Drugs 101 Brain & Addiction
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums
  • BDD Moderators: Keif’ Richards

Tramadol - Safe combos?

Pill2Chill

Pill2Chill

Bluelight Crew
Joined
Apr 11, 2012
Messages
5,517
Location
Belgium
EDIT: Thanks everyone for all your replies. I had forgotten about this topic but found it with the search engine, nice info. I barely take tramadol anymore, and I've always left a decent gap between tramadol and others drugs. (aside from weed and benzos).

Hi I was wondering if tramadol had any bad interactions with one these six drugs:
MXE
4-HO-MET
5-MeO-DALT
5MeO-DiPT
2C-E
25i-nBOMe

Also howlong would you have to stop taking tramadol in order to take the substances that don't mix well with it?

Any advice would be very much appreciated.

PTC%)
 
Last edited:
MXE - MXE is an NMDA receptor antagonist and serotonin reuptake inhibitor and tramadol is an opioid, serotonin releaser, and serotonin/norepinephrine reuptake inhibitor, so the main risk would be too much serotonin effects.

4-HO-MET - Unclear, it's likely a serotonin agonist.

5-MeO-DALT - I have no idea.

5MeO-DiPT - Thought to be primarily a serotonin agonist, but it is suggested that it may have additional mechanisms of action such as MAOI. I would not risk combining it with tramadol.

2C-E - Probably serotonergic in some way. I don't know much about it.

25i-nBOMe - Serotonin agonist and serotonin/dopamine reuptake inhibitor. I would not risk combining it with tramadol.

Honestly I wouldn't personally risk combining any of these drugs with tramadol. But of course it would depend on the doses of each drug. Maybe the Psychedelic Drugs forum could give you some better answers - would you like me to move your thread there? I don't personally know how long you would need to avoid tramadol before taking them, I think it would depend on the tramadol dose, the dose of the other drug and how frequently you take tramadol.
 
Swimmingdancer said:
MXE - MXE is an NMDA receptor antagonist and serotonin reuptake inhibitor and tramadol is an opioid, serotonin releaser, and serotonin/norepinephrine reuptake inhibitor, so the main risk would be too much serotonin effects.

4-HO-MET - Unclear, it's likely a serotonin agonist.

5-MeO-DALT - I have no idea.

5MeO-DiPT - Thought to be primarily a serotonin agonist, but it is suggested that it may have additional mechanisms of action such as MAOI. I would not risk combining it with tramadol.

2C-E - Probably serotonergic in some way. I don't know much about it.

25i-nBOMe - Serotonin agonist and serotonin/dopamine reuptake inhibitor. I would not risk combining it with tramadol.

Honestly I wouldn't personally risk combining any of these drugs with tramadol. But of course it would depend on the doses of each drug. Maybe the Psychedelic Drugs forum could give you some better answers - would you like me to move your thread there? I don't personally know how long you would need to avoid tramadol before taking them, I think it would depend on the tramadol dose, the dose of the other drug and how frequently you take tramadol.
Click to expand...

I would have to agree,at least when combining with psychedelics because of the various areas/ pharmacology of tramadol. Tramadol is a very questionable thing in most combos because of its pharmacology. Only thing I have ever felt "safe" combining with was Klonopin which is at least an anti-convulsant which reduces chance of seizures that comes along with taking tramadol.

Pariahprose
 
I would say at least two weeks. That way it gives the anti-depressant properties of Tramadol to fade, cause those are what effects the substances you wish to use the most. Also, if you have been using Tramadol regularly be prepared to experience both the effects of opiate WD and anti-depressant WD.
 
Really? I've used LSD having waited only 24hours before and it worked perfectly w/o any problems. Do the SNRI properties last for a few weeks after taking tramadol, I thought was only the case with SSRI anti-depressants? I didn't know that.

Thanks for your reply though.

Can anyone else confirm this please? Thanks!
 
No they certainly don't last a few weeks. Tramadol has metabolites that can stick around for a few days, no more than that. IME the SRA/SRI/NRI properties last no more than 24-36 hours.
 
I would never take RC's with tramadol.


Tram is pretty much an RC itself especially if you don't do it often. I've never had a seizure on it on really high doses, but some people have one after 100mg or so.

Tramadol's effect don't last more than 24 hours, after that it's living hell or redose.
 
have you ever tried kratom? it feels similar to tramadol, and has similar strength agonising MOR so similar opiate effects. however, kratom can be safely taken with other RCs and serotonergic drugs because while it does affect serotonin, kratom only minimally affects serotonin levels. kratom also has affinity to DOR which provides a speedy and an AD effect. IMO, kratom feels stronger as an opiate and is much safer to take higher quantities. 10-15grams of high quality kratom feels like 30mgs of oxycodone IR, but in a different way. also. kratom has NRI effects similar to ultram. Finally, kratom is a weak NMDA-antagonist like tramadol

fuck the tramadol dude. trade that for weed or kratom or something. kratom is 10x safer than tramadol and IMO/IME has more recreational and euphoric qualities. as people have said, do NOT take tramadol with any of those substances, especially MXE because MXE is an SSRI.

wait 24-36hrs after your last tramadol dose to take any RCs. tramadol is not a typical antidepressants, and acts very differently than most SSRI's. instead, tramadol is a SRA(serotonin releasing agent), NRI, and serotonin receptor antagonist (5ht-2c, ect.) along with being a slight NMDA-blocker, mu-agonist, ect... and thus won't dampen the effects most psychedelics after 24-36hrs of your last ultram dose. however, MDMA and any serotonergic RC (4-FA, methylone, ect..) won't be as euphoric the day after, or even a week after trams because like MDMA, tramadol is a SRA but to a much lesser degree and will deplete serotonin. this means that the MDMA or SRA RC like methylone or 4-FA wont be as euphoric because there wont be as much serotonin to be released.
 
Last edited:
laCster said:
tramadol is a SRA(serotonin releasing agent), NRI, and serotonin receptor antagonist (5ht-2c, ect.) along with being a slight NMDA-blocker, mu-agonist, ect...
Click to expand...

It was also my understanding that tramadol shouldn't need a long clearance time like an SSRI antidepressant may, but the studies I have looked at said that tramadol both releases serotonin AND inhibits serotonin reuptake.

Just one example:

Tramadol significantly blocked 5-HT uptake and increased stimulated 5-HT efflux. The action on 5-HT efflux preceded an effect on 5-HT uptake, suggesting that uptake block was not the cause of the increased 5-HT efflux and that tramadol might therefore have a direct 5-HT releasing action. [source]
Click to expand...

Am I misinterpreting it? There are a bunch of sources listing tramadol as a serotonin reuptake inhibitor but those seem to mostly be articles that cite another or don't give much info in the abstract, like saying "we investigated the analgesic effects of tramadol, a serotonin and norepinephrine reuptake inhibitor and weak opioid", etc.

This makes me question whether or not someone who takes tramadol chronically should be avoiding other serotonergic drugs for a longer period of time? There are so many cases reports involving tramadol and serotonin syndrome, even some from just taking tramadol, so I want to be cautious.
 
Last edited:
You're right, it is an SRA/SRI. In the case of serotonin syndrome from tramadol alone, it's very possible as any serotonergic drug can cause serotonin syndrome on its own.

In terms of SSRI drugs in comparison to tramadol in terms of activity, they have extremely long half-lives and are highly lipophilic. Much like diazepam they build up levels over-time in the fatty tissues. Tramadol on the other hand is a water loving substance, it's solubility in that respect outweighs that of its solubility in fat. On top of that it has an extremely short half-life, so the chances of overlapping doses will be less of a problem.

I don't endorse however using it with serotonerigcs or not leaving a considerable period of time between dosing it before/after serotonergics. I would have to agree with everything you mentioned in your first post.
 
Swimmingdancer said:
It was also my understanding that tramadol shouldn't need a long clearance time like an SSRI antidepressant may, but the studies I have looked at said that tramadol both releases serotonin AND inhibits serotonin reuptake.

Just one example:



Am I misinterpreting it? There are a bunch of sources listing tramadol as a serotonin reuptake inhibitor but those seem to mostly be articles that cite another or don't give much info in the abstract, like saying "we investigated the analgesic effects of tramadol, a serotonin and norepinephrine reuptake inhibitor and weak opioid", etc.

This makes me question whether or not someone who takes tramadol chronically should be avoiding other serotonergic drugs for a longer period of time? There are so many cases reports involving tramadol and serotonin syndrome, even some from just taking tramadol, so I want to be cautious.
Click to expand...

yes you are right, tramadol and its metabolite have a half life of 6-12hrs.

you are comprehending it currectly. the article says that tramadol acts as a SRA and a serotonin receptor antagonist or "blocker," and the article even says, "tramadol might therefore have direct 5-HT releasing action," in addition to being a slight reuptake inhibitor, however not as selective as SSRI
 
Last edited:
Swimmingdancer said:
It was also my understanding that tramadol shouldn't need a long clearance time like an SSRI antidepressant may, but the studies I have looked at said that tramadol both releases serotonin AND inhibits serotonin reuptake.

Just one example:



Am I misinterpreting it? There are a bunch of sources listing tramadol as a serotonin reuptake inhibitor but those seem to mostly be articles that cite another or don't give much info in the abstract, like saying "we investigated the analgesic effects of tramadol, a serotonin and norepinephrine reuptake inhibitor and weak opioid", etc.

This makes me question whether or not someone who takes tramadol chronically should be avoiding other serotonergic drugs for a longer period of time? There are so many cases reports involving tramadol and serotonin syndrome, even some from just taking tramadol, so I want to be cautious.
Click to expand...

Exactly my point of saying two weeks,to be cautious and minimize the chance of harm to an individual as much as possible.This is a harm reduction site.Also if you are addicted to the tramadol,two weeks would give your body enough time to recover from any WD and the trip could be used to re-evaluate your life and to make progress in it.
 
Yes, it is a HR site, but there are margins within that which you can work with. Not that you have to tread the line between safety and danger, or be overly cautious. Moderate and reasonable advice is optimum when it comes to drug use.

Two weeks is FAR too long.
 
Chromophobia said:
You're right, it is an SRA/SRI. In the case of serotonin syndrome from tramadol alone, it's very possible as any serotonergic drug can cause serotonin syndrome on its own.

In terms of SSRI drugs in comparison to tramadol in terms of activity, they have extremely long half-lives and are highly lipophilic. Much like diazepam they build up levels over-time in the fatty tissues. Tramadol on the other hand is a water loving substance, it's solubility in that respect outweighs that of its solubility in fat. On top of that it has an extremely short half-life, so the chances of overlapping doses will be less of a problem.
Click to expand...

This makes sense. The requirement for abstaining from tramadol before using other serotonergic drugs being much shorter than a normal SSRI antidepressant because it has a much shorter half-life and duration of action, and different properties.
 
You must log in or register to reply here.
Top