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Opioids Tramadol question for Tramadol users

D

daboss

Greenlighter
Joined
Aug 24, 2011
Messages
10
First let me tell you a little bit about my worst withdrawals:

Although I only like to take it for sexual activities, Tramadol hangovers are real strange. I used to never get them, but now I feel tired the next day which hints at taking another dose.

It looks like every 2-3 months, I get flu-like symptoms with unbearable headaches from tramadol for days even if I don't stop taking it.
The last time I went to hospital, neither Ibuprofen or Tylenol helped so I had to ask doctor for something stronger, which ended up being injectable morphine in my IV. This helped a ton.
Been to ER 3 times and each time the doctor wants to make sure I either A) Don't have the flu virus or B) Don't have Meningitis. That's how bad it can get sometimes.
It sucks because it doesn't happen often and it is the only thing that can help me with certain functions.

My questions are:
Have any of you experienced similar situations?
If so, what have you done to help you prevent such a bad hangover?
 
Let me get this straight, a doctor gave you IV morphine for a hangover of tramadol? I take it that you weren't honest with him that it was from tramadol. That's some serious over-medication and borderline ridiculous. I've had meningitis and that was the worst headache in my life. If you are coming in with symptoms similar to mengititis then you may be allergic to tramadol.

If you react that strongly to tramadol, why not take another opioid/opiate such as codeine? If not then decrease your dose. Do you take it so you last longer in the bedroom? If so that's setting you up for a problem down the road.

I've abused tramadol a great deal in obscene doses and never experienced anything how you are describing. Let alone symptoms of meningitis because that's some serious pain. I don't even recall anyone posting about a hangover from tramadol, anything is possible though. I'd definitely take another opiate if I were you.
 
I had been in pain for almost 2 days before I decided to go to the ER. I took ibuprofen all day and the headache wouldn't go away.
Went to ER, they gave me the strongest Tylenols, supposedly, but I doubt it had Codeine. After about an hour still with this severe headache, I told the doctor I needed something stronger and he decided to give me Morphine.
I didn't expect morphine to interact with any remaining tramadol in my system and thankfully it didn't. I did not tell the doctor it could've been because of Tramadol use and yes, I use it for the bedroom since it helps with PE.

Considering using another opiate, but first have to experiment and see what works best. Going to try Kratom for PE and see how it goes, otherwise I am going to doc for meds.
 
sounds like withdrawal most likely, and maybe coupled with the fact that your body just doesnt seem to like tramadol very well.
 
Take a longer break. My experience is that the SNRI effects of Tramadol can fuck you up pretty bad after long term use due to downregulation of your serotonine receptors. The hangover symptoms were always a sign for me to stop. I agree with Brutus' advice, switching to Codeine could solve your problems.
Other than addiction of course...

What doses are you taking btw?
 
DickTate said:
Take a longer break. My experience is that the SNRI effects of Tramadol can fuck you up pretty bad after long term use due to downregulation of your serotonine receptors. The hangover symptoms were always a sign for me to stop. I agree with Brutus' advice, switching to Codeine could solve your problems.
Other than addiction of course...

What doses are you taking btw?
Click to expand...

I would usually take anywhere between 100mg-200mg.
I'm afraid codeine may be harsher on the body?
 
That is a pretty low dose. As far as I know Tramadol has some potential to being neurotoxic when taken over a longer time.
Codeine should be the "healthier" alternative since it has a much cleaner pharmacological profile and does not affect your Serotonine-system.

If you have the possibility you could try to switch. But I guess you would feel the missing SNRI effect for about a week or so if you are physically dependent.
This is why Tramadol Withdrawls can be very nasty, like opioid and antidepressant WD's together at the same time.
 
First off, Tramadol helps you with ED? Opiates always decrease my sex drives, make pissing sometimes a bitch and I never get morning wood. I too take Tramadol here and there, sometimes I go on benders, but usually I stick with it for 2 weeks max.

Recently I took it for 2 weeks, stopped and got the headache that never goes away. Best advice is stick it out. There are MUCH worse WD symptoms that you could be having like puking up bile, restless leg/body syndrome, etc. I've noticed Tapentadol has the same effect. Only worse as the headaches don't even go away if you take more.

I'd take a break. You're body clearly is telling you to. I just got over a Tram/OC binge that reminded what a stupid addiction, binge or vice opiates are. It's really hard IMO to just take them here and there. Eventually it's a daily habit.

By guess is you are going through WD and need to deal with it. Sad but true.
 
DickTate said:
That is a pretty low dose. As far as I know Tramadol has some potential to being neurotoxic when taken over a longer time.
Codeine should be the "healthier" alternative since it has a much cleaner pharmacological profile and does not affect your Serotonine-system.

If you have the possibility you could try to switch. But I guess you would feel the missing SNRI effect for about a week or so if you are physically dependent.
This is why Tramadol Withdrawls can be very nasty, like opioid and antidepressant WD's together at the same time.
Click to expand...
What is the difference between taking Tramadol which affects Serotonin vs taking Oxycodone which affects Dopamine?
 
Tramadol is a pathetic fucking drug and I'd like to beat the living shit out of the people who invented it and make them eat 12 pills only to wait 3 hours for any relief, if any.

One time I was comig off trams after going through 90 or so in about a week. I thought it would be a good idea to jerk off to take my mind off, and I got a terrible fucking throbbing headache. Had to lay down and smoke some weed and a little opium I had left and chugged caffiene like there was no tomorrow.
Found out It's called a coital cephalagia (sex headache), and that was the only time I've ever had one.

I'd take withdrawal from real opiates most days...even wd from opiates feels 10X more natural than tram wd.
 
daboss said:
What is the difference between taking Tramadol which affects Serotonin vs taking Oxycodone which affects Dopamine?
Click to expand...

If you just asked that question you shouldn't be taking tylenol much less tramadol.

Opioids receptors are the money. Oxycodone has a much higher affinity for opiate receps. Tramadol also causes a release of dopamine, but It's activity at opioid receptors is much less than any opioid drug.

Tramadol isn't even an atypical opioid imo, just some freak of science.

Just look at the chemical structures for Christ sake their nothing alike!
 
Treefa said:
Tramadol is a pathetic fucking drug and I'd like to beat the living shit out of the people who invented it and make them eat 12 pills only to wait 3 hours for any relief, if any.
Click to expand...
Definitely my favourite (pro-)opiate. I've had very strong opiods, e.g. IV hydromorphone & IV piritramid, but imho nothings beats Tramadol. It really depends on your enzyme situation. Grapefruit juice and diphenhydramine with it makes a huge difference as well.

And I don't experience ANY withdrawls whatsoever if I slowly taper off it, even after being on it for over 6 months @ 400mg/d. Other opiates make me feel like complete and utter crap for at least 3 days even after a single dosage.

EDIT: It surely IS a freak of science though.
 
took 100-200mg daily for 1 year aprox. and found no difficulty coming off it, just gave some opiate type energy and slight heady feeling which felt more placebo than anything. Though I have a high torrance to opiates and benzos.

Is tramadol a 'real' opioid ?
 
Wobblier said:
took 100-200mg daily for 1 year aprox. and found no difficulty coming off it, just gave some opiate type energy and slight heady feeling which felt more placebo than anything. Though I have a high torrance to opiates and benzos.

Is tramadol a 'real' opioid ?
Click to expand...
One of it's metabolites is. Tramadol itself has no opiate receptor affinity afaik. It is an SNRI though which is part of why enjoy it so much. The first few hours I get some considerable euphoria (SNRI's will do that to me, since I'm bipolar 1) which then transforms into an opiate high that lasts well over 18 hours. It's very empathogenic for me, much moreso than other opiates.
 
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Opiates increase my sex drive and allow for the greatest sex I've ever had. I to use tramadol for increase in stamina. Also it's been found that tramadol is no longer synthetic, as a shrub in Africa produces it naturally.

To repeat, tramadol is a naturally occurring substance produced in nature by plants. It would be great if it was allowed OTC as an herbal supp.
 
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Initiating a research program aimed at discovering natural products as pain relievers, we focused our attention on the sub-Saharan Nauclea latifolia Sm. (Rubiaceae) plant, commonly known as African peach or pincushion tree. This plant has a long tradition of use by local populations for the treatment of a wide diversity of illnesses, including severe digestive problems, neurological disorders and infectious diseases. [1–3] In Cameroon, the plant is used to treat pain, malaria, fever, epilepsy, and infantile convulsions. We were particularly interested in the traditional use of the root bark of N. latifolia in pain relief. Previous phytochemical investigation of N. latifolialed to the identification of alkaloids,
mostly naucleamides, as the main constituents. [4]
Extracts from this plant have shown antipyretic, [5] antinociceptive, [5–7] anti-inflammatory [6] and antimalarial activities. [6]
In this study, a fractionation of the crude extract, guided by the antinociceptive bioactivity, led to the isolation of a potent analgesic compound, which was identified as (+-)-cis-2-[(dimethylami-no)methyl]-1-(3-ethoxyphenyl)cyclohexanol, commonly known by its international non-proprietary name (INN), tramadol. Tramadol was first manufactured by Grünenthal GmbH (Germany) and was brought into clinical usage in the late 1970s

[...]

This indicated a tramadol concentration of 3.9% (w/w) in the ethanolic extract, which gives a content of 0.4% (w/w) in the dried root bark (Figure 3b, c).

Source:
DOI: 10.1002/anie.201305697
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Damn!
 
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I use tramadol quite often. I understand it has snri activity, and people are experiencing terrible symptoms coming off of it after protracted use. From what I gather it's a combination of opiate withdrawal, and "snri discontinuation syndrome"-a sneaky euphemism coined by the pharm companies, meaning "snri withdrawal symtoms"...when I stop using tramadol after months of extended use, I experience none of these horrific symptoms I've been hearing of. Could it be because I'm already prescribed high doses of ssri drugs?
 
dopemegently said:
"snri discontinuation syndrome"-a sneaky euphemism coined by the pharm companies, meaning "snri withdrawal symtoms"...
Click to expand...
Funny thing doctors actually fall for that. My psychiatrist also argued that tolerance to neuroleptics would more fittingly be described by the term acclimatization. LOL

dopemegently said:
when I stop using tramadol after months of extended use, I experience none of these horrific symptoms I've been hearing of. Could it be because I'm already prescribed high doses of ssri drugs?
Click to expand...
I am not prescribes SSRI's and still do not experience these withdrawl symptoms even after months of heavy use. If I stop abruptly I experience classical opiate withdrawls, not so if I taper. I gotta mention that I am bipolar, so SSRI use kinda triggers something in me that lasts much longer than I am taking the meds.
 
After over a month, I was able to get another script. I've taken it for the past 4 days and have not experienced anything but slight headaches and dizziness at 50-150mg.
I've been taking these for almost 2 years and never had this experience.
What is going on?

I would like to note that I took Kratom the day before starting Tram.
 
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