Tramadol / opiate questions - advice needed. Concerning PE

[BE123]

Hi all,

So here's how it is. I'm one of those people who is an insanely good responder to Tramadol. At least, I was.

It's a wonder drug to me. Confidence in a bottle. I primarily used it for premature ejaculation. It would take me from 45 seconds to 45 minutes, with ease. Only on special occasions. I NEVER abused it. A 20 pack would last me a year. Sustained release, so one pop in the morning and good to go for 24 hours.

But here's the thing.

First of all - it is so precariously hard to dose. So finicky and temperamental. I still haven't found out exactly what is doing it, but something (else, food, supplements, hydration level?) has the tendency to absolutely intensify the CRAP out of it.

One day, I'd take 100mg and be fine. Feel great. The next time, 100mg would make me sick to the stomach, spin my head and literally make me want to pass out and sleep. The next time, 200mg was a walk in the park. Then another time, 150mg would make me want to vomit while stationary, until I got my heart rate up.

I have tried logging what I eat, and besides a fatty meal, I have somewhat tracked it down to either potassium, or vitamin E that does this in a HUGE way. Just something worth pointing out (anyone experience the same?), but it is neither here nor there.

More pertinently, here's my issue.

For some unbeknownst reason, I took 150mg a month ago after not taking any for a good 3 months, and it did absolutely ZERO. They were near expired so I figured they'd gone dud.

Off to the docs I went for the off label use for my PE, and I thought I'd try regular release. Different brand, I have never used.

So today I took 150mg (three 50mg) again just to be sure and NADA. I'm not just saying they didn't work well. I'm talking... they didn't work AT ALL. Felt weaker than taking a headache tablet. Which is bizarre considering as stated, they would numb my nervous system so much I couldn't even ejaculate. I also have a sore back and it still aches. They did zilch.

So now I'm worried.

I think it's impossible I've built tolerance. I really do use them very very rarely. But what I'm thinking is

A: The different brand this time. I know it's crazy but I've heard people say only the Ultram is the good one.
B: Too many at once. Would 50mg each hour work better? And when is the peak concentration level for immediate release? If I took sustained, I'd wait 11 hours before they worked the best, and I could have sex. I have also crushed them, but it seems the longer it builds naturally the better it works. Plus the heart rate, sweating and dry mouth of crushed and drinking them can be a PITA.
I only waited 3 hours this time with immediate release, and it didn't seem long enough?
C: I've been taking Mucuna Pruriens. Is it possible I have shifted my Prolactin and Dopamine levels to the point where I'm feeling so good it's overriding the Tram effect? My sex drive and horniness level HAS been insane since them...
D: They've officially pooped out. In which case the whole reason I really started this thread -

For the numbing effect/something to prolong ejaculation and be used in place of Tram, what would be a good substitute?

Oxycontin? Valium? Another opiate painkiller?

No SSRI or anything works. But Tramadol was the one wonder drug for me, and now I'm getting worried it's stopped doing its thing. I am going to wait a week and try again just to be sure.

Cheers all in advance.

 

[Lovecraft]

On the Tramadol effects issue, IME, I've used Tram on an everyday basis for about a year and then off and on for about a year, with dosing days ranging from once every couple days to every couple months with everywhere in between. And I've never had any issue feeling the effects. They were predictable per dosage amount as clockwork.

So it sounds to me that it may not be an issue with you and may either have something to do with the quality of Tram these days (I've heard of Rx formulas changing before) or Mucuna Pruriens interaction.

And I've used both Ultram as well as generic Tram that my vet prescribed for my dog and saw no difference in effect.

Even if you had a tolerance and thus stopped feeling psychoactive effects, I would think you should still have the physical effects of delayed ejaculation, as you would with any opiate.

 

[BE123]

My thoughts exactly, as to wondering what is up.

I posted that only a few hours in, and it seems that immediate release is more or less just a complete cut in half of sustained, rather than instantaneous. IE: It hit me in about 7 hours instead of the usual 11 or 12. But still nowhere near as potent and in quite a weak feeling way. Perhaps I just didn't wait long enough before I had sex. I dosed at 7pm and was still slightly buzzed at 7am this morning. I can never trust the peak blood concentration claims. They claim it's maxxed at 2-3 hours and then dies down. Not the case it seems, for me anyway.

I've used generics exclusively as well with great success, but never a regular release. Will have to try again, or perhaps make a jump back to SR.

Definitely still open to opinions about other opiate meds to try.

 

[BE123]

For posterity, sorted!

No Mucuna on the day of taking.

Meal containing some amount of fats and carbs/sugar (I had chicken, and brown rice in olive oil, then a whole can of pineapple and pure juice). Then took 200mg. Waited SIX hours minimum. Then some of the best sex I've ever had.

Perfect. Not even a hint of stomach upset. Feel fantastic. High but not stupidly spaced out. Immediate release for some reason comes on nice and progressively tamer, in a steady way, than the sudden intensity and die down (repeatedly) of SR.

It ramps up, peaks, stays there, and then gradually fades. SR on the other hand has these hits out of nowhere all at once, then dies down, then another hit, then dies down... rinse and repeat over and over ongoing.