Pharmacology Tramadol metabolism to O-desmethyltramadol

[jambabomba]

Hi,

I have to rapidly downregulate/taper down my massive 1000mg+/d Tramadol usage along with benzodiazepines and gabapentinoids. Simply because I ran out of money and supply. And even though I knew this I waited for too long because...well, I have this addictive tendency in me and my personality is so OCDP that it makes any letting go or surrender extremely difficult.

But now I am forced to taper them all simultaneously and very rapidly, meaning I have to take like 100mg off from Tramadol and 400mg off from gabapentin about ed or eod. Right now I am at 600mg down from little above 1000mg of Tramadol. I am adding low dose naltrexone again to this combo. Starting from 12ug today. 16-20ug tomorrow and so on...4-12ug increments per day.

Because I need to also reduce benzos and gabapentinoid I am trying to find ways to ease at least something so to find a ways to increase metabolism to O-desmethyltramadol.

Is there any other ways than glutethimide? Has anyone experienced anything in practise or does anyone has even some theoretical assumptions that could lead to more being metabolised to O-desmethyl?

Any other advices regarding how to ex. Potentiate absorption of Gabapentin? It seems to be kind of roulette; sometimes it absorps heavily and makes you even nodding with normal doses of tramadol and benzos but sometimes even larger doses have left you in withdrawals.

Thank you for your answers.

 

[emkee_reinvented]

Yeah o-DSMT, depending your location, could be a available RC.
Or Kratom, also a option. To switch/ taper more easy.
So much Tramadol is dangerous, don t get that so much with 0-DSMT.
400 mg imo is allready a lot daily. I can tolerate, 37.5 mg max.

Start with tapering that, maybe a little of the Gabapentin
[causes seizures too, taking it i read/ no clue what WD-ing it would do],
but not the Benzo all at once.

Otherwise i would advise my dr. , which i hate and won t do easily.