Tramadol is not a very safe drug to be taking on a regular basis.
It has a rather nasty withdrawal syndrome, including a higher risk of suicide than traditional opiates.
And 200 mg is a fucking high dose.
350mg throughout the day is even more.
In elderly patients, 400mg is known to cause serotonin syndrome on its own.
In young patients, 400 is still considered to be quite high and definitely lowers seizure threshold.
Taken in combination with ANY other serotonergic drug is a SURE risk of serotonin syndrome.
Since tramadol has a very long half-life, it takes MUCH longer than 12 hours to leave your system.
At the minimum, it is going to minimize your roll because it is a serotonin releaser and you are taking it regularly.
At most, it could cause Serotonin Syndrome.
This is a much more VIOLENT event than the name suggests.
Take it from someone who has experienced it.
It is defined as 'too much serotonin activity in the brainstem' combined with a constellation of symptoms.
Very important - SS is a quick onset disorder.
There is NO warning, it just hits you like a brick in your mouth.
Severe tachycardia is a common first sign - enough to make people dial 911 claiming heart-attack and impending death.
Altered mental state, lack of speech, diaphoresis, abdominal pain, muscle rigidity, and anxiety like you have NEVER felt in your life.
For me the intestinal cramping was SO severe I thought they would burst!
The swelling began just below my stomach and continued south for 3 hours.
Fever is a sign of advanced SS.
101.4 is considered very serious.
At 104 or above, organ damage and death are more common.
Skeletal muscle tissue can break down into myoglobin and destroy your kidneys.
The brain can release SO much anti-diuretic hormone that water fills your intestines and bloodstream.
Then it starts to squeeze your brain.
Stroke and cerebral edema are the greatest risk with SS, but kidney and liver failure are also possible.
Just about every account of SS that I have read indicates something along the lines of - "my insides were tearing me apart!"
Serotonin Syndrome only occurs when two serotonergic drugs are taken together.
MDMA is a POWERFUL serotonin releaser, and is associated with SS with less harmful drugs than fucking tramadol.
I will also point out that during my year long recovery from SS, I have found tramadol to be very risky.
It was previously a preferred drug for me, and I could take 100mg or more without concern.
Now, I take 50mg on rare occasions, and still suffer lots of discomfort, including mild SS symptoms.
Again, the least that will happen is it will minimize your roll.
Opiates, opioids, and morphine simply do NOT mix with MDMA.
Why take these and a stim together?
There is just no logic behind it.
And there is a substantial risk.
You do NOT want to experience SS, my friend.
Anyone who has been there can tell you this - it is among the scariest of events you will ever go through in a lifetime.
Think about this - the breakdown of skeletal muscle that destroys the kidneys...
It is called Rhabdomyolysis and it is typically only seen with CRUSHING injuries, such as during an earthquake!
That is what your body does to itself when trying to compensate for 'too much serotonin activity in the brainstem'.
If you chose to go forward anyways, here is the typical treatment for SS in the ER.
The same treatment is given with 'acute MDMA reactions'.
Lower body temperature aggressively, as this directly modulates serotonin toxicity.
Give the patient electrolytes - this aids the kidneys in removing water from the bloodstream. You should be sipping gatorade.
Give the patient benzodiazapene to control tremors, or even a paralytic agent if necessary.
And if these methods fail to control the progression of symptoms, use a serotonin antagonist to reverse the effects.
Tramadol is a fun drug, but it belongs nowhere near your roll, IMO.
You should be clear of it for at least several days before rolling.
And if you are a regular user of tramadol - give it TWO WEEKS.
Again, tramadol has a LONG withdrawal period.
I don't even recommend that you take it - hydrocodone would be safer.
Good luck.
Sorry I did not help I guess i am saying I would not try it until you can find out. I know there are risks associated with everything.