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tramadol and methoxetamine

neveroddoreven

neveroddoreven

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Aug 18, 2010
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Now sorry if this isnt ADD material, but thought i would get a good answer here. Any adverse reactions/complications mixing the two? only 100mg tram and thinking of 30mg-ish of mxe.
 
dont do it. problems with methoxetamine and serotonin releasing agents. how hard is it to wait till the tramadol is over to take methoxetamine.

new territory let someone else be the guinea pig
 
thats all i was wondering about really, the time frame. I had taken the tramadol 2-3 hours or so before I made that post
 
The risks are:
1. Seizures
2. Serotonin Syndrome
3. Mixing a stimulant with tramadol which is very, very uncomfortable
4. Methoxetamine is a newer drug with very little research done on it. Therefore, there could be some fatal life-threatening interaction between tramadol and methoxetamine that no one knows about yet.

specialspack said:
Tramadol's half life is 5-7 hours according to wiki. I wouldn't chance it if I were you.
Click to expand...

Yes but, the active drug is the one that tramadol's metabolized into (O-Desmethyltramadol), which has a half-life of 9 hours. So I wouldn't take ANY stimulant for at LEAST 3 days after taking tramadol.

Tramadol is not a good drug to mix with anything at all really. Not only because its dangerous and people risk seizures when doing it, but also because its fairly uncomfortable to mix anything with tramadol (even caffeine and cigarettes)
 
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SpunkySkunk347 said:
The risks are:
1. Seizures
2. Serotonin Syndrome
3. Mixing a stimulant with tramadol which is very, very uncomfortable
4. Methoxetamine is a newer drug with very little research done on it. Therefore, there could be some fatal life-threatening interaction between tramadol and methoxetamine that no one knows about yet.



Yes but, the active drug is the one that tramadol's metabolized into (O-Desmethyltramadol), which has a half-life of 9 hours. So I wouldn't take ANY stimulant for at LEAST 3 days after taking tramadol.

Tramadol is not a good drug to mix with anything at all really. Not only because its dangerous and people risk seizures when doing it, but also because its fairly uncomfortable to mix anything with tramadol (even caffeine and cigarettes)
Click to expand...

now i might be missing something here, but how does methoxetamine classify as a stimulant? ive never done it, but have heard at low doses it can be rather stimulating. but either way its MOA, though not completely known, surely does not act in a way similar to cocaine, amphetamines, and other true stimulants.

however, i would not take mexthoxetamine within 24 of a tramadol dose. the point of the above post is one i agree with. just felt the need to point that out, maybe cuz im high, bored, and not tired =P
 
perKeceT said:
now i might be missing something here, but how does methoxetamine classify as a stimulant?
Click to expand...
well, it doesn't really, but it certainly has some stimulant-esque effects (whether or not caused by it being a DRI, I do not know) that I would take a good guess and say would be uncomfortable to mix with tramadol

another reason i left out:
mixing NMDA antagonists can also be quite uncomfortable with certain ones
 
SpunkySkunk347 said:
The risks are:
1. Seizures
2. Serotonin Syndrome
3. Mixing a stimulant with tramadol which is very, very uncomfortable
4. Methoxetamine is a newer drug with very little research done on it. Therefore, there could be some fatal life-threatening interaction between tramadol and methoxetamine that no one knows about yet.



Yes but, the active drug is the one that tramadol's metabolized into (O-Desmethyltramadol), which has a half-life of 9 hours. So I wouldn't take ANY stimulant for at LEAST 3 days after taking tramadol.

Tramadol is not a good drug to mix with anything at all really. Not only because its dangerous and people risk seizures when doing it, but also because its fairly uncomfortable to mix anything with tramadol (even caffeine and cigarettes)
Click to expand...

What is wrong with mixing O-Desmethyltramadol with stimulants? The fact that it is a noradrenaline reuptake inhibitor? Because O-Desmethyltramadol does not carry the seizure risk nor the serotonin syndrome risk that tramadol does.
 
yes, multiple times i've tried taking amphetamine after taking tramadol 2 days earlier, and just gotten this horribly uncomfortable stimulated feeling like i shouldnt have mixed them. I guess I should say "uncomfortable for some" (since this is based on personal experience), but maybe just because a lot of people don't pay enough attention to effects in order to notice. I also never got any euphoria from amphetamine if I had used tramadol recently.

However, whenever I took tramadol after taking amphetamine two days earlier, it wasn't so bad. But there was one time I took tramadol while already on amphetamine (my first clash with accidentally combining the two) and the following 6 hours sucked. I don't know how to describe the discomfort other than a nasty ass stimulant feeling that one might expect to experience when mixing a NRI with amphetamine

a lot of what I'm saying is just speculation and "maybe its true, maybe its not", and other people hesitated to post it because they didnt want to dampen their credibility, but since this thread was started out of harm reduction and not mere curiosity, i posted it anyways just for the OP to be aware of possible risks (assuming speculated risks still qualify as possible risks unless proven otherwise)

Also keep in mind that even if the opiate-esque euphoric effects of tramadol or its metabolites have worn off, it is still very much in your system and very much affecting neurotransmitter levels. I think the common rule of thumb is wait 4-5 half lives, but even though O-Desmethyltramadol's HL is 9 hours, dont forget to calculate that some tramadol was still being metabolized into O-Desmethyltramadol at the end of the tramadol's run through your system
 
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