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Torine esters

N

Neuroprotection

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Torine is a an Important Amino acid with many health benefits, such as Antioxident, Immune boosting, cardioprotective and neuroprotective affects. One particularly interesting affect is its ability to block glutamate excitotoxicity and neuronal apoptosis, partly through GabaA agonism but more importantly Calcium regulation.
Unfortunatly, I have heard that torine may be porly absorbed in the Intestines or struggle to cross the blood brain Barria. However this is disbuted.I am suggesting combining Torine with a lipid soluble group by esterifing it with ethanol to produce the ethyl ester. Another way might be to acetylate it to form torine acetate.
What do you all think? These are just suggestions so I don't know how or if they would be of any benefit, so please forgive me if they sound stupid.
 
This topic is probably more appropriate for Neuroscience and Pharmacology Discussion.

Also, we can't discuss synthesis as it is against the rules.

I'm not familiar with torine. Did you mean taurine?
 
^I'm certain Neuro means Taurine, I believe Neuro doesn't have the use of their eyes and uses a text-to-speech program.

Interesting to see that homotaurine is a precursor to Acamprosate. Some anti-anxiety effects of Taurine appear to be mediated by glycine receptors... Sadly I have no advice on increasing bioavailability as I am piss poor at chemistry
 
I think the questions should be:
- Taurine and its pharmalogical profile
- 'Protected' Taurine Derivatives? Any value on bioavalability, distribution on body, effects? It can either be Sulfonate ester (Taurine-SO2-OR) or Amide (RCOONH-Taurine)
 
neuroprotection, were you high or drunk when you made this topic. how can you not be able to spell taurine properly, a very well known amino acid, but also you repeatedly say "torine" making me think you didnt know how to write it properly to begin with lol

anyway, im curious how does one acquire homotaurine as thats the one having the best bioavailability in the brain with the most potent neuroprotection. it would have been awesome to be able to get it OTC *sigh*
 
sekio so they work the same way? or, acamprosate is just a better advanced version of homotaurine? if thats the case i guess one should avoid the later, but initially i thought trying to get a hold of both.
 
Acamprosate is the N-acetyl ester of homotaurine - so it should both have similar activities as well as function as a prodrug for homotaurine. I would expect it'd have better bioavailibility, not to mention the fact it's an approved drug whereas homotaurine would "technically" be a research chemical (not sure if it's in the pharmacopeia)
 
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