Too Much Dexedrine?

[xxpurplehazexx]

I switched from Adderall XR to Dexedrine spansules due to the nasty PNS side effects I was having after over 3 years of use. My normal dose of Adderall XR is 15-20mg and my pdoc wrote me a prescription for 20mg Dexedrine. Today is the first day taking the dexedrine and I feel kind of sick. My heart doesn't feel weird (a major plus), but I keep having these hot/cold flashes and bad muscular tension. I had the same sort of side effects when I took too much Adderall, so I'm guessing dexedrine is more potent. I was also wondering if anyone has experienced/heard of side effects associated with dexedrine that are different from adderall XR. Lastly, how long (from experience) do Dexedrine spansules stay in the system compared to Adderall XR?

 

[pasha]

I think you're withdrawing from the levoamphetamine as it has a specific and separate target/mechanism of action than dextroamphetamine. Especially on the cardiovascular system which could impose sympathetic/autonomic dysregulation during withdrawal.

Just give it time and you'll adjust to the dextroamphetamine alone.

 

[xxpurplehazexx]

So its not more potent?

 

[Midazle]

Isn't Adderall racemixture Adderall mixed with dextroamphetamine while Dexedrine is just Dextroamphetamine? Wouldn't that make the Adderall more potent given the Dexedrine doesn't have the other half of the mix (levoamphetamine) or is adderall mixed to keep the dose equivalent? I always forget.

 

[pasha]

So its not more potent?

I'm not sure which one you're referring to, they just work on different sites in the human brain. Think of it as if you were dependent on two separate amphetamines instead of one. Dextroamphetamine is more potent to the neurochemical system, and levoamphetamine is more potent to the cardiovascular system. This is why levoamphetamine is notorious for inducing bold peripheral effects. The withdrawal from these potent cardiovascular effects is what's largely contributing to your symptoms.

Amphetamine exists as two stereoisomers that differ in effects 5. The l- enantiomer (levoamphetamine) produces more cardiovascular and peripheral effects than the d- enantiomer (dextroamphetamine). At low doses, levoamphetamine produces greater arousal than dextroamphetamine, acting primarily on norepinephrine. At higher doses, dextroamphetamine has stimulant properties that are three- to four times as strong as those of levoamphetamine, and acts primarily on dopamine.

Source:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670101/

The current amphetamine that you're on will surely tide you over pretty easily in a very a brief period of time since they have some overlapping properties.