tobacco and DMT

[atara]

Note: please, please, please do not smoke cigarettes because of this thread if you are not already a smoker. Tobacco can really fuck up your life.

The presence of MAO-B inhibitors in tobacco is well-known. It is less known that MAO-A inhibitors are also present in tobacco leaf, and these have clinically significant effects on MAO-A activity in human smokers:

http://www.pnas.org/content/93/24/14065.short

It is therefore a question of some interest whether the effects of metabolically labile compounds, particularly DMT, may be affected by tobacco use. Does anyone have experience with this?

(a more reasonable option for non-smokers is changa, don't smoke cigarettes)

 

[buildersoftime]

I'm not sure that a 'breakthrough' is as quantifiable as mr Mcenna liked to think. I know some people say that it's like an orgasm; when you've had one you know. But I've smoked DMT in all manner of ways in all sorts of quantities. I've been a long way out, all the way to loss of consciousness in fact. I've had a wardrobe get up and start walking towards me, all manner of creatures and people appear out of thin air and with my eyes shut, even the mildest doses these days produce entities that (strangely), seem to be mostly made up of hands.

After all this, I'm still not really sure what a breakthrough is. I can only assume that Mcenna's attempt to create a vocabulary to frame the DMT experience is as lacking as it is useful.

Or maybe it's because I'm a non-smoker.