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TMA-2-NBOMe
- Thread starter psykap
- Start date
planckunit
Bluelighter
- Joined
- Aug 8, 2007
- Messages
- 105
i have heard:inactive up to 3 mg
TMA-2-nbome should be inactive, or of less potency than TMA-2
If you look at the papers where Nichols discussed the nbome's, he reported that n-substituents killed activity in amphetamines, while greatly increasing it in phenethylamines. So, it sounds like you can either add an alpha-methyl, or an n-substituent, but not both, to increase potency - which would imply that the alpha methyl and the NBOME group want to end up in the same place on the receptor.
If you look at the papers where Nichols discussed the nbome's, he reported that n-substituents killed activity in amphetamines, while greatly increasing it in phenethylamines. So, it sounds like you can either add an alpha-methyl, or an n-substituent, but not both, to increase potency - which would imply that the alpha methyl and the NBOME group want to end up in the same place on the receptor.
It is, indeed, inactive in the dose mentioned, although left me with the impression that there might be some activity at tens of mgs like in DOB-NBOMe. That might actually be just some common NBOMe's effects on the physical level, but without noticeable 5-HT2A-agonist action we want. I don't think these may be worth buying the chemical 8). It is highly probable most people won't feel anything more than an indefinite and short threshold intoxication at any dose. There might be few weird exceptions of high sensitivity among us however: of a dosen people who participated in it's collective bioassay there was one who had found it to produce mild psychedelic effects at 3 mgs (intranasally). Others barely felt anything at all.
I wonder how such structure could become of any interest to the rc supplier who actually made it. It will most probably become impossible to sell after reports of it's inactivity surface.
2,4,5-TMPEA-NBOMe is much less active than 2C-B-NBOMe, or any other we may consider highly active, including 2C-D- and even 2C-CN- NBOMe. Like regular TMA-2 that is active at 40 mgs, while it's 4-bromo congener DOB is active at 2 mgs. It looks like methoxy group at PEAs 4th position is only little better than a hydrogen atom (i. e. no substituent at all) in 2,5-DMA and 2C-H-NBOMe. Somewhat better, but not that much better as halogens or alkyls. DOB-NBOMe with it's "good" bromine atom at 4th position is only slightly psychoactive, and never becomes much stronger at higher doses. Why then TMA-2-NBOMe turns out to be commercially available now? I suspect there is no logic behind this, but simply it's vendor has some useless precursor to 2,4,5-trimethoxy PEAs, or the one that is readily available and straightforward.
I wonder how such structure could become of any interest to the rc supplier who actually made it. It will most probably become impossible to sell after reports of it's inactivity surface.
2,4,5-TMPEA-NBOMe is much less active than 2C-B-NBOMe, or any other we may consider highly active, including 2C-D- and even 2C-CN- NBOMe. Like regular TMA-2 that is active at 40 mgs, while it's 4-bromo congener DOB is active at 2 mgs. It looks like methoxy group at PEAs 4th position is only little better than a hydrogen atom (i. e. no substituent at all) in 2,5-DMA and 2C-H-NBOMe. Somewhat better, but not that much better as halogens or alkyls. DOB-NBOMe with it's "good" bromine atom at 4th position is only slightly psychoactive, and never becomes much stronger at higher doses. Why then TMA-2-NBOMe turns out to be commercially available now? I suspect there is no logic behind this, but simply it's vendor has some useless precursor to 2,4,5-trimethoxy PEAs, or the one that is readily available and straightforward.
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I'm assuming that whoever is providing this compound is selling something other than what they're telling you it is. That would pretty stupid of them to spend all the loot to have this compound synthed when just about everyone else who's heard of these compounds and some of their mothers know that the NBOMe-Amphetamines are inactive.
I was thinking that too...
Especially if they're bothering to make TMA-2, which is a real gem of a chemical in it's own right, and very hard to find on the market.
If even specifying what it should be, or actually is. It has something of a deception, although I don't think the actual vendor ever thought about cheating anyone, their buisiness is to produce it, there is nothing unfair about offering this as a research chemical with no specific uses. What to think of it and use it for is up to the person buying it.
