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Misc Tizanidine's allegedly hallucinogenic potential?

Esperighanto

Moderator: PD, MDMA, DS
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Jul 19, 2023
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Probably Tripping (Maine -> Florida)
Hey guys, I recently got my hands on 50x2mg Tizanidine tablets (small, yellow, Indian pressing I think?) and I had heard around that 8-10mg insufflated with no tolerance can induce hallucinations akin to Z-drugs, assuming you can stay awake. Has anybody ever experienced anything like this? If not, could you compare them to benzos, propranolol, clonidine, or Soma at all?
 
Well it's more centrally acting than say clonidine, given tizanidine's higher selectivity for the alpha -2C receptors, so it's going to have more central effects. It's also more sedating from what I recall. My guess is that any hallucinations occur between sleeping and waking states, especially from the sleep state to waking state (hypnopomic hallucinations). But I'm sure it could occur in either direction. I don't think the hallucinations would resemble those produced by z-drugs, which occur during the waking state and are more overt. For instance, take 60mg of zolipidem and fight to stay away and just about anyone will start hallucinating. I guess the only commonality would be a dream-like quality.

Hypnopompic hallucinations are weird. I remember waking up at like 4am, and in the shadows of the room (the room had some light trickling in from the blinds) I saw a homeless black dude leaning against my wall, standing with one leg on the ground and the other bent, touching the wall. I never really saw him closely or talked to him, but my body was completely paralyzed -- I couldn't move a muscle. The paralysis was far more scary than the black dude, but he definitely was ominous. It felt like it lasted 15 minutes, but who knows how long it was.

My guess is that tizanidine hallucinations are of that nature; as you are waking up the typical noradrenergic system that helps you "turn on" isn't functioning fully, letting your mind go to transient places for atypical periods of time, such as waking dreams states.
 
Well it's more centrally acting than say clonidine, given tizanidine's higher selectivity for the alpha -2C receptors, so it's going to have more central effects. It's also more sedating from what I recall. My guess is that any hallucinations occur between sleeping and waking states, especially from the sleep state to waking state (hypnopomic hallucinations). But I'm sure it could occur in either direction. I don't think the hallucinations would resemble those produced by z-drugs, which occur during the waking state and are more overt. For instance, take 60mg of zolipidem and fight to stay away and just about anyone will start hallucinating. I guess the only commonality would be a dream-like quality.

Hypnopompic hallucinations are weird. I remember waking up at like 4am, and in the shadows of the room (the room had some light trickling in from the blinds) I saw a homeless black dude leaning against my wall, standing with one leg on the ground and the other bent, touching the wall. I never really saw him closely or talked to him, but my body was completely paralyzed -- I couldn't move a muscle. The paralysis was far more scary than the black dude, but he definitely was ominous. It felt like it lasted 15 minutes, but who knows how long it was.

My guess is that tizanidine hallucinations are of that nature; as you are waking up the typical noradrenergic system that helps you "turn on" isn't functioning fully, letting your mind go to transient places for atypical periods of time, such as waking dreams states.
Thank you for the info here! I'll get around to testing it once I finish tapering off carisoprodol, I'm taking it real slow rn as I'm in the only month out of the last ~5 years of my life where I'm not working a 9-5, so I've become a carisoprodol connoiseur in a pyramidal scale of use, escalating and then deescalating haha. Just don't want to risk mixing muscle relaxants.

Soma's potentiation of psychedelics is fascinating to me, and it makes me wonder if tizanidine or cyclobenzaprine alongside LSD, miprocin, 2C-B, allylescaline, etc. may be as interesting as LSD + Carisoprodol was. I'm not sure if I've ever written much about that here but it was one of the most fascinating trips of my life, and that's saying a lot as it's out of probably 350+ total trips so far.
 
Yea I agree.

I have occasionally dosed 4 mg, more commonly like 1-2 mg. Up to something like 8 mg/day. With weed and benzos and opioids. Not psychs or dissos. I don't use regularly.
 
Yea I agree.

I have occasionally dosed 4 mg, more commonly like 1-2 mg. Up to something like 8 mg/day. With weed and benzos and opioids. Not psychs or dissos. I don't use regularly.
Thank you for the information here! I suspect that people experiencing hallucinations on it in reports may have just been profoundly sleep deprived yet still fighting the sleepiness for some unwritten reason, leading to, as @negrogesic pointed out, something akin to hypnopompic hallucinations.
 
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