Titratrion of MXE into Liquid-Filling Capsules?

[d-chaser]

Titratrion of MXE into Gel Capsules?

I have a bit of a dilemma that mainly stems from me not having access to a scale more accurate than 0.01g. I have some powder I need to separate into 10mg doses, so this was my idea:

1. Dissolve 0.10g of powder into 10.0mL of water.
2. Inject 0.50mL of solution into size "1" capsule using a syringe.
3. Two capsules = one 10mg dose

The problem is that all the empty gel capsules I found seem to be made for powder, not liquids. It seems I'm actually looking for softgel capsules, but I can't find empty softgels anywhere.

Does anyone have a suggestion? Will regular gel capsules hold liquids without spilling? Is there an easy way to seal them if they won't? Anything else I can do with an aqueous solution to store 10mg doses? I'm not sure if I can safely evaporate the water from each 1.0mL dose without vaping/smoking the powder.

Edit: Shite...wouldn't water actually dissolve the capsule anyway? I think I'm back to square one

Edit: I've come up with a new method.

1. Step 1 from above.
2. Fill the portions of an ice tray with 1.0mL each of the solution
3. Evaporate water by either: a) putting ice tray under an incandescent lamp or b) floating it in an inch of hot (not boiling) water in a baking pan on top of a stove on lowest heat.
4. Encapsulate powdered doses.

Can anyone tell me if this wouldn't work for some reason? Would the light from the lamp damage certain kinds of powders?

 

[Tommyboy]

Just tell us what drug you are working with, then I will send it to the appropriate forum. Light and heat affect various drugs in different ways, so we can't answer your question til we know which drug you are working with.

 

[d-chaser]

Sorry, I was just being extra-cautious since I'm a bit new here. The powder is methoxetamine (MXE).

 

[Tommyboy]

O.K. The psychedelic drugs forum might be able to help you out. They talk about liquid titration there too.

Homeless --> PD

 

[d-chaser]

Thanks. I think I've worked out what I'm going to do for the tolerance I need, although I'm still waiting for feedback on whether or not light/heat will do anything to the MXE:

1. Weigh out 100mg of powder using a scale (accurate to +/-2mg).
2. Dissolve in 10.0mL of water (accurate to +/-0.09mL).
3. Separate into 0.50mL half-doses of solution (accurate to +/-0.03mL) using a syringe and an ice tray.
4. Evaporate water using either an incandescent lamp or baking pan of warm water over a stove on lowest heat (floating the tray).
5. Encapsulate powdered half-doses (2 capsules = 10mg = 1 dose).

I figure this will give me a final tolerance of (or maybe *slightly* better than) +/-0.5mg per 5mg capsule, which I think is fine for MXE. Am I doing this right?

 

[Korn3x]

sorry i'm slightly confused. why does the MXE need to be in an aqueous solution?

 

[d-chaser]

Because I want to cap doses for transporting (I'm not going to have the scale with me wherever I am), and I'm not comfortable doing this with the +/-2mg tolerance of the scale (I want to be able to control doses in 5mg increments—using only the scale means that an attempt at three '5mg' doses could end up anywhere between 9mg and 21mg). I don't have access to a more accurate scale, so I'm going to dissolve a large amount of powder in a larger amount of water and weigh by volume to get more precise amounts. Unless there's something else I should be dissolving it in. I've seen this measure-by-liquid method discussed on here several times for various substances.

Edit: Unless you're referring only to my original post. I don't plan on keeping it in an aqueous solution for the capsules, I'm going to dissolve the water to extract the powder again (after separation). I only want to know if using light or heat to evaporate the water will do anything to the MXE.

 

[Incunabula]

I think you should dissolve your MXE in isopropyl alcohol. I´m sure it will dissolve easily even without heat.

Use a syringe to measure out your doses. Then squirt each dose onto a large mirror, or another large smooth surface. IPA evaporates really quickly even at room temperature. You can now scrape up the 5 mg doses with a razor, and put into capsules.

That said, your tech could definitely work as well. I´m pretty sure MXE won´t take any kind of damage from a little heat.

wikipedia/Isopropyl_alcohol

 

[d-chaser]

Thanks for the input. Isopropyl would speed things up for a first run, so I'll try that. Might switch to water afterward to avoid wasting alcohol. And I just realized that it might be difficult to get powdered doses out of an ice tray, so I'll go with a large, smooth surface.

 

[greenmeanies]

Don't try making the drug powder again after you add it to liquid.

Just use liquid measurement to get your 10mg doses (oral syringe, vodka, etc) and squirt those into PRELABELED disposable water bottles. I suggest also adding food coloring to make it clear that these are NOT FOR HUMAN CONSUMPTION and KEEP OUT OF REACH OF CHILDREN etc.

 

[d-chaser]

Don't try making the drug powder again after you add it to liquid.

Just use liquid measurement to get your 10mg doses (oral syringe, vodka, etc) and squirt those into PRELABELED disposable water bottles. I suggest also adding food coloring to make it clear that these are NOT FOR HUMAN CONSUMPTION and KEEP OUT OF REACH OF CHILDREN etc.

Is there a particular reason I should go about it this way? Would diluting 0.5mL of solution further in water/vodka hurt the potency at all? I'd either be carrying 4 or 5 bottles of only 0.5mL each or I'd have to drink even more than that of vodka/water solution. Would the evaporating method not work?

 

[greenmeanies]

The evaporating method will work, but you will probably lose ~10% of your dose in the collection and packaging of the powder (have you ever really tried to gather up 10mg of crystalline substance from a flat surface, and somehow convince it to enter a gelcap without sticking to your fingers?)

If you keep it in liquid form until it is consumed, there is less chance of it disappearing somewhere. And you can be sure of getting 99.9% out of the water bottle at the end.

1. Gather your plastic water bottles and permanently mark each one with the dose it will contain.
2. Add 100mg MXE to 100mL water. Thus you have 1mg/mL water.
3. Using an oral (baby medicine, no needle) syringe, draw up 10mL of water (containing 10mg of MXE) and squirt it into the first empty, clearly labelled bottle. If this bottle is labelled "10mg", congrats, you're done, cap it up and distribute.
4. If the bottle is labelled "20mg" or "X mg" continue adding your MXE solution to it until it contains the appropriate amount. It's just math, not rocket science.
5. At time of consumption, instruct those who are partaking to drink the little puddle of water, and then add a small amount of fresh water to the bottle. Shake and drink this to recover 90%. Repeat with another splash of water to get 99%. Repeat a third time for approximately 99.9% rinsing of the bottle. Obviously those with weak constitutions may elect to replace water with juice to mask the taste.