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tilMETamine

klfiend

Bluelighter
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Just created, trialing soon. I anticipate it it to be 7-8x potency of ketamine judging by alkyl chain reduction from ethyl to methyl group off amine compared to tiletamine.


Side note, can a methoxy group be stuck on a thiophene ring? Also where would you stick it to make the thiophene analog of methoxetamine?
 
Ive thought about this before and been surprised no one has synthesized it up until now. Tilpropamine and tilisopropamine should also be decently potent.

I remember reading a research paper a while back on TCE, TCeM and TCPr. If Im not completely lost the difference between TCE and Tiletamine is N-Ethyl on a cyclohexylamine vs 2-ethylamino on a cyclohexanone and rest of the structure being the same? Forgive me if that was really unclear and wrong Im bad at chemistry and havent slept a wink yet 😅
 
No worries friend, you call tiletamine O-TCE, or call TilMETamine O-TCM

Deschloroketamine could be called O-PCM or everyone knows O-PCE or eticylidone.

Tiletamine is 10x as potent as ketamine, I would wager the alkyl chain reductions would make tilmetamine roughly 5-7x potency or ketamine.

When I tried methoxmetamine it was about 1/2 potency of methoxetamine, all I base my guess on. I suppose we shall see soon after tasting it.
 
Interesting, I think the bond angles of the thiopene are slightly different than benzene, but I feel like substituents in different benzene positions in either adjoining position on the related arylcyclohexylamines are active, so if thiopenes handle the electrostatics the same as benzene, it would likely be interesting.

Edited for grammar and clarity
 
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- Should have my sample in a day or so

Midweek at latest. We'll begin trialing around that time. My thoughts is probably to dissolve it in a solution, perhaps a nasal spray. That would probably be the only way for it to have any viability. Thoughts?
 
Interesting, I think the bond angles of the thiopene are slightly different than benzene, but I feel like substituents in different benzene positions in either adjoining position on the related arylcyclohexylamines are active, so if thiopenes handle the electrostatics the same as benzene, it would likely be interesting.

I can only extrapolate from using mephedrene which has a methyl group at the thiophene Ring. Just from looking at it it should be about to be in the same place as the 4-methyl group of mephedrone but after trying it just felt like 3mmc so i guess thiophenes substitute angles are different enough from phenyls that you dont always Reach similar results when using the same substituents.
 
.. what an undesirable substance.

Very long-lasting.

20 mg. Felt like it lasted eternity. Never would do that again
 
.. what an undesirable substance.

Very long-lasting.

20 mg. Felt like it lasted eternity. Never would do that again
Care to elaborate? Do you think you just dosed too high? Any chance of being recreational? This was the only new NPS I have been excited about for the US market in a while.
 
I won't rule out that possibility. I did a bit of a full trip report. I only took 20 mg. It's possible that that safe range would have been around 2 to 5 mg. Internasal. It lasted an incredibly long time.

That said, 3 days later I am back to baseline so. I just would recommend anyone to start at the lowest dose possible, and do not redose

Tilmemetamine

Not remotely caustic in nature. No afterburn.


Crushed up very finely, chosen route- Internasal

Controlled dosage- 20mg

Will update accordingly my experience

Within the first 20 minutes, feeling a disconnection to body.

Still have relatively good motor skills. Possibly even enhanced. No speech issues/ cognitive impairment recognizable thus far. Feels like a full body glow as Bingbong described initially.

-30 m

Still feels as if I am slowly gradually not quite there reaching a peak. I still no issue with mobility, focus or execution of high level tasks.


-60

Motor skills, mildly diminished. Was attempting to play a game for a bit. Wukong. Lost focus. Choosing to lay down now. Will pursue other activities That require less thinking/input.

90m

Significant body rewriting-
Someone who has never experienced disassociatives would have difficulty figuring out how to control their motions in all likelihood. Slight distortions. Auditorial enhancement, and a glowy fuzzy effect looking at screens reminiscent of other analogs.


Nothing resembling a hole/CEV at this current point

100m

We seem to be approaching some sort of peak here. Incredibly heavy bodyload. Needed to lay down. Very much a non subtle tranquilizing effect. Heavy feeling around the chest region.


What followed after that was the feeling of an extremely heavy tranquilizer, no CEV still no hole. Was rather discombobulated for the next couple days, did not want to pilot a vehicle. Had some tremors, body shakes.. I also have an incredibly high tolerance. 100mg o-pcm is a functional dose for me.
 
Cold. Again no perceivable hole or CEV. I did not enjoy the experience personally. Perhaps at a far lower dose 2-4mg It could have been very different. Unsure if willing to research again
 
I won't rule out that possibility. I did a bit of a full trip report. I only took 20 mg. It's possible that that safe range would have been around 2 to 5 mg. Internasal. It lasted an incredibly long time.

That said, 3 days later I am back to baseline so. I just would recommend anyone to start at the lowest dose possible, and do not redose

Tilmemetamine

Not remotely caustic in nature. No afterburn.


Crushed up very finely, chosen route- Internasal

Controlled dosage- 20mg

Will update accordingly my experience

Within the first 20 minutes, feeling a disconnection to body.

Still have relatively good motor skills. Possibly even enhanced. No speech issues/ cognitive impairment recognizable thus far. Feels like a full body glow as Bingbong described initially.

-30 m

Still feels as if I am slowly gradually not quite there reaching a peak. I still no issue with mobility, focus or execution of high level tasks.


-60

Motor skills, mildly diminished. Was attempting to play a game for a bit. Wukong. Lost focus. Choosing to lay down now. Will pursue other activities That require less thinking/input.

90m

Significant body rewriting-
Someone who has never experienced disassociatives would have difficulty figuring out how to control their motions in all likelihood. Slight distortions. Auditorial enhancement, and a glowy fuzzy effect looking at screens reminiscent of other analogs.


Nothing resembling a hole/CEV at this current point

100m

We seem to be approaching some sort of peak here. Incredibly heavy bodyload. Needed to lay down. Very much a non subtle tranquilizing effect. Heavy feeling around the chest region.


What followed after that was the feeling of an extremely heavy tranquilizer, no CEV still no hole. Was rather discombobulated for the next couple days, did not want to pilot a vehicle. Had some tremors, body shakes.. I also have an incredibly high tolerance. 100mg o-pcm is a functional dose for me.
Interesting, sounds very potent from your report. If 100mg O-PCM is a functional dose for you how much stronger would you estimate Tilmetamine is compared to regular ketamine?

From what you stated it sounds even more potent than 3-HO-PCP which is the most potent of the more common arylcyclohexylamines used

Maybe it would be more enjoyable/desirable in low doses as an addon to more ”magical” dissos? Say 2-3mg Tilmetamine and 15mg 3-MeO-PCE perhaps?
 
Do not try this compound...
I created an account just for this purpose.

I took approximately 400mg - 500mg over the course of 3+ days. And holy shit was that a mistake. It was wayyyy too much.

I took the tilmetamine 20 days ago.

Tbh, I enjoyed the buzz. But the amount and the consecutive days were a problem. I would say 5mg would be a proper first time dose for anybody to understand what they're in for.

I experienced extreme vertigo for ten days, dilated pupils still now 20 days later and shaky hands for two weeks.

The positive does not outweigh the negative for this one. Sorry guys, better I tell you now!!
 
Yes, I absolutely agree with this. It's now three weeks since I did approximately 500mg over 3 1/2 days. I experienced shaking, vertigo with inability to walk straight and still experiencing vision problems.
 
I haven't been able to find but one single repot here and one on reddit. I'm looking for all available reports so I may message you to see what you've heard exactly. I have the opportunity to try this one.

Not entirely hopeful.

I'll say this, if a dissosciative gives that amazing post-game depression relief, I could give a crap if it has boring effects. Ideally, that would not be the case but I'm someone who benefits from that attunement that happens after dissosciative experiences, and that's what I'm always hunting for. For that purpose, nothing has compared to 3-meo-pce.
 
I did 5mg and then 10mg. Insuffulation
Probably going to label and then shelve this one indefinitely.

Reminiscent of memnatine in taste. 15 minutes after insufflation, body awareness is visceral like one was coming up on a small dose of dxm. Been away from nicotine for half an hour, took a drag off my disposable vape and felt a massive rush. Got worried for a sec.

Had some marijuana, vital. If this is what *it* is, then its not worth risking the side effects noted in this thread. No clue if it has a hole.
 
A French team developed and tested a number of tiletamine derivatives. I found it the most detailed paper on NMDA antagonists since that paper from the 60s that tested PCP derivatives:


The compound in the image is covered by BE634208A although it doesn't appear to be that much more potent than ketamine. I suppose if one were to specify the (S) isomer then obviously that would double the potency, but you can likewise obtain (S) ketamine, or 'Esketamine' as some marketing genius worked out.
 
FLUSH IT. OR GIVE IT TO SOMEONE YOU TRULY HATE.

that is the only use case. I will not respond further to this thread. THank you for your understanding- I have a TG group for HP awareness
 
Has anyone gotten this stuff tested? I believe there has only been one batch made. I did get to name this for the vendor, got a 2 gram sample that I didn't get around to trying. I will pay to get it tested. This compound shouldn't have long lasting side effects...

I've experienced muscle tremors with dissociatives, especially O-PCE. Experienced uncomfortably long vision changes with 3f-pcp. Side effects lasting weeks sounds like a messed up synthesis. Sounds like straight up toxicity.
 
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