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tiletamine

psychedelic nod

psychedelic nod

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Mar 28, 2008
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I know that this compound is mor epotent and longer lasting than ketamine, but I was wondering if anyone has had any experiences or encounters with it? it seems like some pretty interesting stuff.
 
I have had telazol (tiletamine + some obscure benzo), and the experience was not especially pleasant. It felt dirtier than ketamine, however I can't conclusively say that benzo did not contribute to this dirty feeling.

Nevertheless, my guess is that tiletamine is not all that great on its own...
 
ok so it pretty much sucks, nevermind then.
I was thinking about trying it as I currently have access to it, and I havent been able to get ketamine ever (though i want to), but im just gonna wait for lady K
 
I would try it if I were you. It's not a ketamine replacement obviously, but it might be pretty interesting, especially in combination with other things.
 
^ Thread necro lol. ^
On a side note, i would want to find out so badly what colour tiletamine goes on the mandelin test result, So would anyone with access to both a mandelin test kit and some tiletamine do the test for me?
 
I expect the furan will not metabolize - the thiophene will at least go to a 1-oxo-thiophene in tiletamine.

Heterocyclic PCP analogs are generally not very good dissociatives though.
 
Tiletamine causes a headache, confusion, dysphoria, a shitty "buzz" and cardiovascular stress. Don't bother.


edit: apparently what I had was TCM not Tiletamine
 
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Here's the facts as far as I can divine them.

Tiletamine is not used in "pure" form like ketamine is, so "diverted tiletamine" is mostly or entirely zoletile (50mg/ml each of tiletamine and zolazepam, Telazol) which has a much different qualitative response than plain arylcyclohexylamines (I think). Zoletile interferes much less with serotonin SERT/5-HT2a and dopaminergic DAT/D2 receptors when compared to ketamine/xylazine. (ref:http://www.ncbi.nlm.nih.gov/pubmed/12715241 - In layman's terms, this means TLE is much closer to a "pure dissociative" like mk-801 with less fun/magical/enlightening/euphoric activity.)

Tiletamine potently displaced the binding of [3H]1-(2-thienyl)cyclohexylpiperidine with an IC50 of 79 nM without affecting sigma-, glycine, glutamate, kainate, quisqualate, or dopamine (DA) receptors. Like other PCP ligands acting via the NMDA-coupled PCP recognition sites, tiletamine decreased basal, harmaline-, and D-serine-mediated increases in cyclic cGMP levels and induced stereotypy and ataxia. Tiletamine was nearly five times more potent than PCP at inhibiting the binding of 3-hydroxy[3H]PCP to its high-affinity NMDA-uncoupled PCP recognition sites. However, following parenteral administration, dizocilpine maleate (MK-801), ketamine, PCP, dexoxadrol, and 1-(2-thienyl)cyclohexylpiperidine HCl, but not tiletamine, increased rat pyriform cortical DA metabolism and/or release, a response modulated by the NMDA-uncoupled PCP recognition sites.
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http://www.ncbi.nlm.nih.gov/pubmed/1847186

Tiletamine is more potent than MK-801 or ketamine at inhibiting calcium channel activity. (http://www.ncbi.nlm.nih.gov/pubmed/1338108)

Doses are typically "comparable to ketamine" if you're using it for anesthetia, but Erowid experiences suggest it's 3-4x as potent as ketamine, and doses start at ~5mg IM, possibly as high as 20mg IM. (well, starting with 5mg of each til and zolazepam, or 0.1ml Telazol) I cannot find a good figure for the half life of the compound, but it's similar to MXE (~2x longer than K). Since abuse is mostly by veterinarians from diverted Telazol there are very few "clean" tiletamine experiences. I did see it being sold on the UK "research chemical" scene but I trust that shit about as far as I can throw it. The few Erowid experiences with tiletamine also suggest that it's not very pleasant at all.

A semi-related drug, TCM (thienyl cyclohexyl methylamine), was known to be sold as "MXE". Someone tested it via GC/MS and found that the compound was likely TCM in high purity. I think it's more likely that other freakish drugs like TCM are being sold as MXE or used to curt MXE, rather than tiletamine - if you're going so far as to make tiletamine you may well be making MXE.

Metabolism of the thienyl compounds to thiones (thioketones) is one route of elimination, oxidisation of the amine might be another, glucuronidation and hydroxylation like with ketamine is another possiblity.

re: MXE, It's my personal belief that MXE has very small or insignificant affinity for the mu-opioid receptor. I think it does have considerable activity at dopamine DAT and d2/d3 receptors due to the 3-methoxy addition. (evidence for this includes mood lifts, compulsive usage, euphoria/mania, strong stimulation in some.) Perhaps it is also 4' hydroxylated in vivo, like with PCP? Compared to tiletamine, MXE is definitely preferable to some extent simply because it is more pleasurable.
 
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sekio said:
Tiletamine is not used in "pure" form like ketamine is, so "diverted tiletamine" is mostly or entirely zoletile (50mg/ml each of tiletamine and zolpidem, Telazol)
Click to expand...

telazol has zolazepam, not zolpidem.

can't even imagine how nuts that stuff would be if it was half ambien haha :)
 
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