Tiflorex/ Flutiorex

[wungchow]

This little bugger just popped up on wiki. It's supposedly a plain-jane anorectic, but very potent.

Interesting meta-substitution on the phenyl ring.

 

[Limpet_Chicken]

looks very like fenfluramine to me, except with a thioether linkage to the trifluoromethyl group, and relocated from position 3 on the phenyl ring to pos.5.

I'm not well up on stimulant SAR, as I hate stimulants, but I'd be careful with this stuff, fenfluramine was taken off the market as it was found to be a 5HT2b agonist, which buggered about with the regulation of cellular proliferation in heart valves with regular use.

 

[LuxEtVeritas]

well here is a pretty comprehensive full text link:

http://www.pubmedcentral.nih.gov/pagerender.fcgi?artid=1428817&pageindex=2

 

[Riemann Zeta]

Looks just as sketchy as fenfluramine when it comes to 5-HT2B agonist activity. I don't think that it was ever released for widespread clinical use and considering what we now know about fenfluramine-mediated cardiac valve fibrosis, I doubt it ever would be.

 

[dread]

and relocated from position 3 on the phenyl ring to pos.5.

What's the difference?

 

[Hammilton]

I'm not sure that there is, the substitutents are both meta to the amine.

studies say it "increases SE transmission" (I assume this means release?) and that "mirthless laughter" is a side effect.

That latter bit sounds a bit like psychedelia (or psychosis!)

 

[dread]

Yeah, if the molecule is "symmetric" then there is no difference between 3 and 5 positions, as there is no difference between 2 and 6 positions.