I take sulphate to treat chronic pain. 50mg 2-3x/day depending on how bad the pain is. I like it because it lasts about 7-8 hrs. I don't take enough to get a buzz, it's just for pain.
I forgot to mention that sulphate Is acting 4-5 hours longer than sodium. 7hrs of painkiller activity Is definitely better than 2-3 hours like in case of sodium version. I had lots of tianeptine sodium prescribed ( they don't use it anymore for depression since they discovered it Is low potency but pleasurable opioid with additional function of raising dopamine ( noticable increase ). I always think about tianeptine sodium as something like even shorter acting codeine without need for your liver to metabolize it into something, just advantage of not being prodrug but in my case it doesn't matter because my CYP2D6 liver enzyme is doing its job better than Is normal. When i take 200mg IR tramadol, 25 % Is rapidly converted into ODSM-T ( desmethyl tramadol has simmilar mor affinity as oxycodone and half-life twice as long + additional analgesia produced by monoamine release and reuptake inhibition, some NMDA antagonism. This means, for some people is 200mg tramadol like a mix of 50mg longer acting oxycodone with NRi activity which greatly improve analgesia and as a bonus potentiation by weak opioid but very fast acting SNRI, tramadol. Also other metabolites but the main psychoactive, analgesia inducing and instant antidepressant effects ( 1 hour instead of days to weeks unlike other SNRIs which need even 2 months for producing desired effects). This monoamine effects of tramadol always reminds me responsible dose of amphetamines - instant mood improvement, very good for pain that doesn't respond to typical opioids, acetaminophen or nsaids. And duration sometimes up to 9 hours Is another advantage of IR tramadol compared to other casual IR opiods because they ( most of them ) have half-life of 3 to 5 hours without ability to prolong it after chronic administration and this Is next unusual but great advantage of tramadol. Monoaminergic opioid which prolong Its duration after using more than just one dose Is not that common. Sometimes after few days of using tramadol, IR version produce analgesia, mood improvement, insomnia and eliminating of pain for even 12 hours.
Great medication if u are very fast CYP2D6 metabolizer who doesn't take big doses of SSRIs, SNRIs ( always avoid antidepressants that inhibit your CYP2D6 liver enzyme.
Be careful, don't get completely addicted to it because high amount produce nasty seizures, Muscle tremor, serotonine syndrome.
It's possible to take even 1500mg daily but with enough benzodiazepines and idealy with leveteracetam ( anticonvulsant ). This very high doses are better for my pain than any other opioid, much better analgesia than 200mg oxycodone but without anticonvulsant and benzos u can't take so big dose because u will vomit or experience very nasty seizure or other many times fatal health problems ( stroke, something like general body collaps - it will turn u off and wake up after 20-40 minutes if u are lucky and survive.
Start with 100mg as a single dose and if u will be ok after using 300-400mg in 24 hrs, maybe try dose of 200mg. Its effects are noticable much faster and u will probably feel some kind of opioid/stimulating antidepressant effects, like big increase in motivation, energy, music sounding better, increase in talking and probably desire for some kind of physical activity because of increased energy and very noticable decrease in all types of pain. No wonder it's favorite painkiller for profesional athletes, cyclists and swimmers or for people with ambition to run fast, don't feel fatigue....great for marathon runners.
And it's medication with best score in category of antidepressants, better than any other medication used or just tried to use as a treatment for depression.
Funny, not even one medication used to treat depression reached better score and better user recensions than medication used for pain or sometimes even for premature ejaculation.
