Tiagabine & benzos

[Ivanhoe]

"Tiagabine enhance the activity of gamma aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. "

"Tiagabine blocks GABA uptake into presynaptic neurons, permitting more GABA to be available for receptor binding on the surfaces of post-synaptic cells. "

(RxList)

What would happen if benzos were taken by a person on Tiagabine?
Would benzos be potentiated?

 

[Limpet Chicken]

I would think so, so long as tiagabine is not a competitive GABA reuptake inhibitor, interesting, although I would be very, VERY careful if I were to mix the two, and I wouldn't mix it with alcohol.

It might be interesting to see if it would potentiate Amanita Muscaria, as that is a GABA-a agonist with no respiratory depressive properties.

 

[BilZ0r]

It shouldn't potentiate muscimol, but it should potentiate benzos...

 

[Ivanhoe]

I tried it, IV, Tiagabine is a very strange drug by itself.(*)
Many things GABA-like, about the memory, loss of motor control, but a little something SO much different.

But I didn't notice much difference with benzos...

(*it has very few binders, and ok ones; seems ok to shoot)

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Tell me if I understand well: it acts the same way as Prozac for serotonin, except for GABA, that's it?

What's the difference (in itsekf and in potentiation og benzos) with:
Vigabatrin
Pregabalin
Baclofen
Gabapentin

All these molecule share same similaritires, don't they?

 

[BilZ0r]

Tiagabine is the SSRI but for GABA
Vigabatrin inhibits the metabolism of GABA (like MAOIs but for GABA)
Gabapentin/pregabalin both effect calcium channels, not GABA-directly
Baclofen is a GABA-B receptor agonist.