phase_dancer is the pharmacological expert here, so I can only offer quantitative comments about using speed (it's methamphetamine, but close enough) and tramadol.
I use tramadol on a daily basis, it's OTC over here in Malaysia and the Hexal/Salutas Pharma ones are the affordable ones @ US$ 0.15 per 50 mg tramadol capsule when purchased in bulk. 5 x 100 tablets.
It seems that a lot of people seems to dislike this pharmaceutical, but I'm quite fond of it.
It gives me a minor, but noticable serotonin boost about 30 minutes after taking it and it peaks at about lunch before starting to wear off at around 4 pm.
The non-standard time-effect description is due to the fact that I use it daily to make me happier and more sociable at work. The workday starts at 8 am but I take it before that, usually at 7:30 am, and the rest of the time should be clear from this start inference time
Regarding the speed + tramadol combination, I've had that several times - not on purpose, but rather due to circumstances. It's worthy to note that I now take 100 mg of tramadol on M, 150 mg on T, etc. 50 mg increments per day.
I did notice a slight serotonin release when I took 400 mg of tramadol and then IV and smoked meth 4 hours later. The feeling isn't quite like the usual tramadol peak serotonin boost, but a more intense one that I would liken to MDMA.
Before anyone flames me for my heretical comparison of this combo with MDMA, it really does feel like that for about 30 minutes. I was afriad that it was a little too much, I just felt extremally, nay, too happy, like a good, solid MDMA pill.
It was during work, so I had to exercise restrain, but I couldn't stop grinning. I'm very familiar with methamphetamine and tramadol but have never mixed them before.
Anyway, I don't know if this had anything to do with the serotonin or just tramadol + meth hypertension (existing medical conditon), but my head felt like it was about to explode after the initial euphoria passed.
Again, please note that this is a qualitative description, and I forgot all about pharmacology (lifestyle hazard
) but it felt like too much meth or a meth run that's gone on too long - the usual suspects like perceived cranial pressure, pressure behind the eyeballs, migranes, tarchydia etc.
It was quite unpleasant for an hour (was lying down), but felt better after that and smoked more meth and everything was fine from that point, though I can't say whether it's coz of the meth or that the tramadol peak has passed.
However, I've also had tramadol with 5 x Novatis Ritalin SR 20 mg (crushed in an attempt to defeat the sustained release) and the result can be summed up in one word - unpleasant. It was worse than meth + tramadol.
I had to keep on taking lorazepam + clonazepam coz of the tarchydia - it was beating so hard and fast I thought I was going to kick the bucket. I would definately avoid this combination again. I'm interested as to why Ritalin (which isn't an amphetamine based substance, though
Hope that helps.
I drink a strong cup of coffee with my tramadol dose each morning, that usually puts me in a good mood.
Thanks for the link phase_dancer, was about to take tramadol before I go to work, and after reading that, I don't think it's a good idea, considering the meth. Cheers!
P/S - I know I should USFSE but I've got to get ready for work and I suddenly remember thats I took 13 x 30 mg dihydrocodeine (DF-118). I know that it binds to the mu opoid receptor, but doesn't it release dopamine as well?
I'm feeling perfectly fine, but if dopaminergic drugs is contraindicated against tramadol, isn't DHC + meth a bad idea?
I've always liked tramadol + DHC (in that order) since the former seems to potentiate the latter.
