• N&PD Moderators: Skorpio | thegreenhand

  • Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

Thoughts on JWH-18 carcinogenicity

MurphyClox said:
^The methoxy-group at JWH-081's naphthalene-ring is supposed to serve as some kinda metabolic handle. A usual route of metabolism would be demethylation, thus avoiding the necessity for cancerogenic epoxide-intermediates.

This is - again! - much speculation, because the human metabolism of JWH-081 is not known, but I'd think that JWH-081 should be safer with respect to harmful metabolites than JWH-018, -015 and -073.


PEACE! Murphy
Click to expand...

Is there anything else (speculations) to worry about with jwh-081?

Thanks for your answer!
 
^Nothing in particular to myknowledge. As usual, overdoses with such potent full agonists are very unpleasant.

- Murphy
 
I was going to ask, as already asked above, why couldn't a group be added to napthalene making it pretty safe?

It seems there should be a bunch of jwh compounds that should give similar effects without having to worry about napthalene.
 
^There are actually some AAIs that possess exactly what you are asking for, e.g. JWH-081. The list of published AAIs is very long and possibilities are numerous (for example the highest JHW-number that I found is ca. 380, but in this list are several THC-derivatives, too. Not everything with a JWH-prefix is an AAI!).

There are also bioisosteric replacements known for the naphthalene, which retain activity, but these shall not be part of this discussion. Do some own research ;)


- Murphy
 
Sorry if this thread is only about 018, couldn't find a general "JWH and health" thread.
ok i'm no chemic pro ;)

I am smoking blends (or JWH/CP's) since 3 - 4 years now. I bet lot of people did more, kinda good i can't afford it every time. However, it was not a little.


2 months ago i was doing some health check because of interest. Too bad i wasn't directly talking from it to the doc.

- Lung check showed up nothing, all fine. Standard slight smokers signs. I am a strong cigarette and bong smoker.

- Blood check also showed up nothing, no carcinogenic markers and nothing related bad stuff.

- Liver data meant i have a bit increased liver value. bet it was the JWH-xxx depleting - of course taking longer than THC.

- When on JWH, blood pressure goes down

Still i would like to know if JWH is reacting aggressive to the liver or just passive - kinda "wholesome". and does really 100% of the compound come out?
I am sometimes trying to eat raw garlic and drinking much water, but i don't know if this makes much sense.

By the way, did anybody measure what is given free when burning JWH? Toxic stuff or something?
 
Last edited:
Which of the JWHs are currently believed to produce the least amount of risk to the user?
 
Jwh-250 (among many others) lacks the napthalene whch some suspect is dangerous. But all this is pretty speculative, they could all be safe. Or dangerous.
 
It looks like napthalene hits the CYP1A1 substrate on cytochrome P450, which also processes a few related xenobiotics. At least it seems unlikely to produce potentiation or other interactions.
 
Volcano said:
Among which others 8) por favor
Click to expand...
jwh-030,051,133,147,171,203,307,359. I realize many of these are not commercially available (yet) and not all will prove recreational. Then there is the win and cp stuff. There are tons of these things, people will be sorting through them for years.
 
I've read some research about jwh-081 showing it doesn't seem very harmfull or harmfull at all. At least not cancerogenic. Anyway, could anyone post the research since I've seem to have lost it?
 
Would JWH-018 likely produce the same anti-cancer effects as WIN 55,212-2?

I have three studies in PDF format which demonstrate that WIN 55,212-2 effectively inhibits tumor growth and metastasis in lung, glioma, thyroid, lymphoma, skin, pancreas, uterus, breast and prostate carcinoma at up to 71% from the controls.

Seeing as they both share the naphthalene ring does this mean it may not be so worrisome after all?

I can upload the PDF's if anyone is interested.

10wnx9d.jpg
 
what do you guys think about jwh-211?... no ones really said anything about it.
any input how what you guys would GUESS about the toxicity of this compound?

i blasted about 30mg of it this week and i put it down after reading this post...lol
the other post about "jwh freak-outs" did not really worry me so much..


and am-2201

whats up with that ? lol
same questions i guess...

thanks guys
 
You must log in or register to reply here.
Top