Thiophene posibilities.... / CLEAN - chem masturbation thread ;)

[BLreturn11]

I would normally post this is the designated "chem masturabation thread" but it seems to be cluttered with truely artistic molecules with no hope of reality/basis for pharmacological studies (i.e literally art with molecules). I know "chem masturbation" is the bane of some users lifes but could we create a lone thread designated for "random" chemical structures with at least some logic and intrigue to back them up.... ??

ANYWAY the big shocker for me (post-PEA & Tryp ERA so to speak) was the thiophene moiety (*completely unresearched and YES dangerous as in not even related to an established drug (with exception of benzene = thiophene - eek), please tread carefully) quite successfully "representing" the benzene ring: This has inspired me to the the shear possibilities that medical/synthetic chemistry really DOES have in relation to NEW drugs...an almost exponential curve of possibilities both legally sanctioned medical drugs and *cough* grey market RC chems (the ultimate tragidy rigtht now is RC chems are coming out what 10x AT LEAST faster than legal medicines for diseases states very in need of inovation...I digress).

Ok so some thiophene analogues to stimulate discussion (mabybe start a chem masturbation thread WITHOUT rubbish and pretty moleculor pictures ?! I am "new" to BL but ever hopeful)

http://s11.postimage.org/901fgcqgz/thiophene.jpg

1) thiomodafinil
2) thiophenidate
3) thioMEPHEDRONE (*STRETCH!*)
4) thioramadol (*STRETH!*)

 

[ebola?]

This would have been fine in the chemical masturbation thread and would have likely gotten ample replies. I'm not sure how great your thiophene cyclohexamine will be, as tiletamine sucks.

ebola

 

[BLreturn11]

http://s8.postimage.org/ix2um4wut/thiophene2.jpg

1) thiophenidate
2) thiobaclofen (*stretch!*)
3) thiomescaline (*Stretch!*)

http://s12.postimage.org/hwmbeitql/thiophene3.jpg

1) thiometrazine
2) thioaminorex
3) thio-indanylaminoindane
4) tryptamine thiophene bio-isotere (see below nichols publication)
5) thio-piperazine (BZP analogue)

No disrespect indended, I often dont frequent the promotion of such information also but my intrigue (for lack of anyone to speak to about it) got the better of me!)

There are clear possibles: Methylphenidate being one? maybe the beneze ring *I could imagine* is easily replaced; BZP (ok a LOT of people didn't like it ) but a replaced benzene ring might not do too much alteration in effect. As for the opioids, well not expecting (and not hoping) they hit the RC scene but can imagine (as with thiofentanyl) would work??

urgh... I actually regret posting such in depth chem analogues of open forums but wish I had a productive (or a mate) to discuss such intrigue with!

BLR

 

[BLreturn11]

^theres one articles referencing Nichols paper (or student) synthesizing the thiophene tryptamine bio-isotere. Can't access full articules....wait yes I can...

http://www.murple.net/nichols/nichols-thienopyrroles.pdf

ANYWAY...I guess my overiding point is medicincal chemistry is so exponential in possibilities (fully explored or just synthesized)...a tragically interesting area to venture in to..

BLR

 

[ebola?]

Well, SAR wise, the thiophene homologue of meth appears to be more adrenergic and less dopaminergic, while vastly less potent overall. Not too promising for other phenethylamines in the series.

This is pretty meager preliminary info though.

ebola

 

[BLreturn11]

I agreee ^ MPA

Methylphenidate (well if my memory surves me correctly, rodent students on DRI's? studies of some sort) shows no holding back on adding two chlorines, or taking away nitrogens. I.e suggests quite a bit of flexibiliity...

Basically still there are a LOT of molecules out there where the benzene ring is JUST (the back bone - for want of a better scientific word) as it were, not the crucial binding component.

As for compounds like BZP benzylpiperazine (but the thiophene analogue) - I am guessing TRUELLY no background knowledge to make any informed guess as to effects or dangeous side effects.

This isn't really a PRO-thiophene ring "rant"; it just reinspired me as to the possibilities of MANY simple molecule compounds out there that are either a) hard to make or b) simply unresearched. (again shame drugs for serious illness aren't progressing as fast as RC's at the moment, most definately exponential, whilst licensed drugs seem to be on a decline)

bLR

 

[ebola?]

Basically still there are a LOT of molecules out there where the benzene ring is JUST (the back bone - for want of a better scientific word) as it were, not the crucial binding component.

Not really. Thiophene homologues of compounds containing benzene tend to be active precisely because thiophene is benzene-like.

Methylphenidate (well if my memory surves me correctly, rodent students on DRI's? studies of some sort) shows no holding back on adding two chlorines, or taking away nitrogens. I.e suggests quite a bit of flexibiliity...

Amphetamine retains activity with a lot of different ring-substitutions too...

ebola