Thiaminorex RC stim.. be careful!

[paracelsius]

Here is a quote from some other forums:

The fact that Levamisole is a major ingredient of Cocaine in the US since quite some time now and that the expected massive outbreak of pulmonary hypertension did not take place raises some questions for sure.
It boils down to two possibilities:
- The whole "Aminorex causes pulmonary hypertension" thing is just utter bullshit (this is what I think*)
or
- only levo-Aminorex causes PH, not dextro-Aminorex. As Levamisole is a chiral medication of the "natural" configuration and it its metabolized to dextro-Aminorex alone.

But even IF it was true and all Aminorex would cause PH it would afflict at most 0,2% of those who use it daily for a prolonged time and as PH is a cumulative disease, say it must be triggered and existing to get worse and worse by self-reinforcement, just using 5 mg Sildenafil or Tadalafil daily will simply suppress the outbrake completely. Those meds were developed exactly for this and are prescribed in this doses for exactly this purpose and they work very well.

* I think Aminorex was slandered and pulled because it was in the process of getting FDA clearance not for weight-loss but as a medication for menopausal women to restore lost libido for them. What parts of the press and medical establishment slandered as a "Sex drug for women". I mean, it was still the 60's, early 70's back then. So yes, there was more to it then just weight loss and judging from the fight the test-groups put up when they were told that tests are discontinued and the drug banned it will have been a lot more I would say.

Synthesis is not as trivial as 4-MAR. Seems very similar to Amph/Meth where Meth is so much easier.
Aminorex is prone to Hydrolysis, so its more then questionable if Cyanates will give any yields worth to mention, not as far as I know. But well, what do I know.

 

[paracelsius]

a medication for menopausal women to restore lost libido for them. What parts of the press and medical establishment slandered as a "Sex drug for women"

Totally agree and I can see why. I thought meth makes you horny. that one blew meth out of the waters. hands up! and any stimulant and psychedelic for that matter. Sex is out of this world. heavenly! not the non-sensical meth-horniness, flapping your poor dinky to pulp for 15 hours straight which meth does. your poor dinky that refuses to collaborate because of vasoconstriction. That one has no stimdick afaik then again that is N=1. (2 with my GF!) More like marathon erotic-psychedelic-love-making" rather than "animalistic-fcking" of meth. My GF loved it ..

Stimulation is as intense but not pushy like meth where the drug take control of the sex, but clean smooth confident you are in charge kind of stimulation. Probably because this class is the most maniac I can think of. So that may be due to maniac effect, very maniac. again not the bombastic coke-meth-pyros type of mania.. but calm confident you can do anything mania, almost psychedelic.... Too bad that compound got a bad rap

 

[paracelsius]

One more thing about this class: there is no comedown at all, like with other stimulants. The reason being that there is no serotonin and dopamine depletion that causes debilitating depression post-mdma and other shitty effects of stims on comedown. Actually quite antidepressant. cf that paper I mentioned above in calves "there were no depletion of endogenous catehcolamines..." https://pubmed.ncbi.nlm.nih.gov/5062875/

and this one comparing it to MDMA in mice

The effects of aminorex and related compounds on brain monoamines and metabolites in CBA mice

Abstract: Acute and long-term neurochemical effects of aminorex, an appetite-suppressing drug related to amphetamine in chemical structure, and stereoisomers of its analogues were examined and compared with those of 3.4-methylenedioxymethylamphetamine (MDMA) and fenfluramine. Aminorex and its analogues, with exception of 4S, 5S-dimethylaminorex, did not cause the long-term neurotransmitter depletion in either the dopaminergic or 5-HT-ergic systems that was observed after MDMA or fenfluramine in CBA mice. These results are discussed in terms of possible structurally related mechanisms of neurotoxicity...
https://pubmed.ncbi.nlm.nih.gov/9120777/

Good'day All BLighters..Stay Safe Out There

 

[snmfmy]

^ pardon me, but that is bullshit..a myth, an urban legend. never been proven! here is a study in dogs:



another one in calves:

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pubmed.ncbi.nlm.nih.gov

ALL THREE PEOPLE caught with 4-MA having Pulmonary Hypertension isn't a coincidence given the Austrian outbreak associated with Aminorex in the late 1960's.

But you do you.

 

[logos_rising]

Here is a quote from some other forums:

- only levo-Aminorex causes PH, not dextro-Aminorex

Here is a quote from some other forums:

If true, this would also apply to the illicit 4-MA available in 2000 as well since a portion of the racemic cis 4-MA would have contained the levo isomers. Moreover, it is the levo, not dextro isomers, of natural phenylethanolamine derivatives, such as R-methylphenylethanolamine and synephrine that are active @ adrenoceptors. The use of natural synephrine-containing products for fat loss has been accompanied by numerous reports of cardiac adverse events, such as thrombosis, coronary spasm, hypertension, tachyarrhythmia, variant angina, cardiac arrest, QT interval prolongation, ventricular fibrillation, myocardial infarction, and even sudden deaths in recent years.

 

[4DQSAR]

PubChem

PubChem is the world's largest collection of freely accessible chemical information. Search chemicals by name, molecular formula, structure, and other identifiers. Find chemical and physical properties, biological activities, safety and toxicity information, patents, literature citations and more.

pubchem.ncbi.nlm.nih.gov

The stuff has been researched for a few things, but no animal models.

Could it be that the stuff has MAOI activity as this would increase levels of extracellular monoamines?

I believe someone performed analysis on home-made 4MAR and they used a thiocyanate in the synthesis so the thio analogue was found as a side-product. They warned that it might be problematic.

 

[obviously_not_carl]

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pubmed.ncbi.nlm.nih.gov

ALL THREE PEOPLE caught with 4-MA having Pulmonary Hypertension isn't a coincidence given the Austrian outbreak associated with Aminorex in the late 1960's.

But you do you.

It is important to note, that 4-Methylaminorex seems to be more toxic and prone to causing PH than plain aminorex.

Also, there was a genetic factor in that specific case, two of them were blood related (uncle and nephew IIRC), the third was the spouse of the one guy.
And who knows how much they used given the quantities found at their place (I think it was more than a kilo?).

 

[Smyth2]

Chem Ber 1914, 47(2), p 1448. https://doi.org/10.1002/cber.19140470219
pretty old paper. I was just wondering if author mentioned any yields. No I guess what he meant the rx product (the residue.. sometime they do have clay consistency like finely suspended solids...I doubt he' rubbed on clay!! rubbed = suspended in HCl (salzsauer, yea?).. poured into ammonium hydroxide..(free basing it).... crystallized from lots of water into rhombic crystals...soluble except in ligroin..blablabla... not to worry too much I know what he’s talking about now.. Thx a lot you save my day

I read the reference you provided and the compound mentioned is Rhodanine.

 

[4DQSAR]

It is important to note, that 4-Methylaminorex seems to be more toxic and prone to causing PH than plain aminorex.

Also, there was a genetic factor in that specific case, two of them were blood related (uncle and nephew IIRC), the third was the spouse of the one guy.
And who knows how much they used given the quantities found at their place (I think it was more than a kilo?).

Interesting detail but ALL of the holologues with an MD ring or bioisostere thereof (think Benzo Fury) and in animal models. all were toxic. The 4-methyl derivative being the most unpredictable.

Because obviously MD seemed like the obvious one IF you intend to study the scaffold.

IF I had to guess, then ethynyl homologue of mephedrone. The para ethnyl holologues of several related compounds have similar SERT:NET:DAT as MDMA.

1-(4-Propynylphenyl)-2-pyrrolidin-1-yl-pentan-1-one

1-(4-Propynylphenyl)-2-pyrrolidin-1-yl-pentan-1-one | C18H23NO | CID 11594677 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

pubchem.ncbi.nlm.nih.gov

1-(4-Ethynylphenyl)propan-2-amine

1-(4-Ethynylphenyl)propan-2-amine | C11H13N | CID 55219741 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

pubchem.ncbi.nlm.nih.gov

There is also a tetrahydroisoquinoline antidepressant which has nice data that fits into JNJ-7925476.

BTW the last one is bizarre.

Without a doubt the series was the last example of rational design. The idea of distomers being of special import.

With sub-Nm ED50s for modulation of extracellular dopamine, what makes it so potentially interesting is that by no means is it an easy target hence offering several much simpler compounds (some commercially available). If tasting a cathinone and amphetamine with a p-CH≡CH just to confirm.

The thing is, it MAY take a year but then a pirate would need a year and you had a year to reduce costs.

Essentially, much like Uber, you become a worthless and yet irreplacable part of the whole thing.

Empathy - we wanted our AR to be called 'Empathy'.

But empathy? It's just a word.

 

[Flynnal]

^ havent try that.. only oral and snorted .. I guess you can vape but I wont go there. lest you ended up 5 days straight doing absolutely nothing but hittin pipe with a totally unknown compound. Dont do it I repeat again: That compound is extremely compulsive starting at 10 mg even insuflatted!.. as compulsive as pyros. GF had to flush 100s $ worth when she start havin tinnitus (ear ring!!) Just stick to meth if that is your doc..

I bet I know what the tinnitus was caused by: Overexcitation of the trigenimal nerve leading to a vasospasm. Common cause, especially if we're talking only one ear, but it can even happen in both because it happened in mine, first the right, then the left started to fuck up...Just like that. I spoke to a doctor recently who diagnosed me with migranous vasospasms that were affecting craniofacial nerves. I'm taking Verapamil sustained release 180mg daily and have just graduated to 240mg/day for that problem because it happens even WITHOUT touching ANY drug LOL.

 

[4DQSAR]

I bet I know what the tinnitus was caused by: Overexcitation of the trigenimal nerve leading to a vasospasm. Common cause, especially if we're talking only one ear, but it can even happen in both because it happened in mine, first the right, then the left started to fuck up...Just like that. I spoke to a doctor recently who diagnosed me with migranous vasospasms that were affecting craniofacial nerves. I'm taking Verapamil sustained release 180mg daily and have just graduated to 240mg/day for that problem because it happens even WITHOUT touching ANY drug LOL.

I will have to take your word for that. I've read multiple accounts of people consuming stimulants via a parentheral route and experiencing various audatory hallucinations. The 'bellringer' so commonly mentioned by people who inject cocaine.

The body has a whole raft of defences to prevent toxins entering the body and so bypassing them is inherantly a risky process.

I do keep saying this but the way things are heading, it's only a matter of time before one or more RC will be discovered to be a chronic toxin.

I've seen hundreds if not thousands for instrumental data sets and sad to say, the vast majority of RCs contain known carcinogens.