Thiambutenes

[haribo1]

These opiates are only used for animals. Similar in potency to morphine and some interesting structural features (never seen asymetrical N groups making things stronger before). What's the deal with it? Is it too toxic for humans or what? Good thing that only the dimethyl, diethyl and the strongest, methyl ethyl, are controlled. I wonder about the piperidine and morpholne analogs.

Can anyone fill in the gaps?

 

[Ham-milton]

I'm pretty sure that diethylthiambutene is used in humans in Japan, actually.

At least in the US, I'm almost certain that they aren't used in humans because of abuse liability (and that they had been previously)

 

[haribo1]

So, they have a high abuse liability. Sort of like oxycodone. For the analgesia the drug gives, the high is too good. I remember William Burroughs was hooked on Eukadol (ampules of oxycodone). He said it was the most addictive drug he ever took and even a gradual taper was horrendous.

 

[Ham-milton]

yeah, they definitely have abuse potential. I'm pretty sure they're "more enjoyable than heroin."

 

[MattPsy]

They sound good, haha. *researches*

 

[fastandbulbous]

Yeah, the thiambutenes seem to have too much of an abuse potential, hence not being taken up in most parts of the world. The piperidine & pyrrolidine compounds have a similar sort of activity, but I don't have a clue about the morpholine derivative