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The substituted 4MAR series

haribo1

haribo1

Ex-Bluelighter
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Nov 29, 2006
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To my knowledge, only 4-flouro 4MAR has been tasted, and that was deemed to be pretty damned good. I wonder, has anyone heard of people working through the series? The substituted propiophenone is a good place to start. Halogenate the beta position, then aminate it. Reduce ketone and you have the substituted PPA for KOCN->Product. Since people have mentioned substituted permolines, I can only think work HAS gone into it, but I can find no real evidence. I mean, the stuff is 1/2 way between meth & E as it is, so the methylenedioxy version may be very euphoric indeed (or totally without action, by the same token).

:| =D %)
 
I'm sure someone on here said that the methylenedioxy analogue of 4-MAR had turned up in germany a while back?

4-MAR analogues are something I've always been interested in too but I always figured the substituted norephedrine precursors would be too hard to get.

The risk of cardiac fibrosis from excess 5HT2B activation would be a worry though given that aminorex itself produces this effect, does 4-MAR have the same problem?
 
Do you have personal experience with 4-Fluoro-4-MAR?
If I recall correctly atleast two members of the Hive synthesized and bioassayed this compound (separately) and both found it to be more or less inactive, was there some further light shed on the matter latter?
 
One of them (Hive members) was a friend and while the first time on para-fluoro 4-MAR was fantastic, it very rapidly lost all it's delightful quirks, such that after the 3rd or 4th time with it, it would just cause a jittery, slightly twisted (not in a good way) sort of high.

Well that's just a personal opinion - you can't make sweeping generalizations with only a handful of test subjects/experiences
 
At Wikipedia, it mentions under Aminorex (I think) that the MDMA analogue of it would be "quite risky," I assume because of it's (assumed) lower potency, increasing the risk of pulmonary hypertension.

Besides Clominorex, have any other substitutions on the phenyl been tried? I assume that the MD-aminorex or MD-methylaminorex haven't been synthed or tasted yet.
 
Aminorex, though of a shorter duration, is a far more powerful analog of 4-MAR... About 400% the potency and FAR more euphoria, with a somatic rush that can leave you stunned... Aside from the euphoria, which IMHO outclasses meth as meth outclasses AMP, it has a horrifically insidious tendency to make one overtly psychotic in a very short period of time, totally without any awareness of the user.

If all the gravel in your driveway has been placed in neat rows organized by size, take a deep breathand a few xanax, and let someone else tell you what you really did for the last few days, Chances are, it isn't what you thought you had done.

Moderation in all things, but with this the compulsion to chase the intoxification is insidious.

Remember, 7-8 mgs was considered a therapeutic dose...

500 mg in a day is not a good thing.
 
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^ "If all the gravel in your driveway has been placed in neat rows organized by size, take a deep breath and a few xanax" - ROFL :D . Thanks dude, that gave me a good laugh!

Yeah this series interests me a lot. Has sparked my interest in researching it again. Can anyone recommend any papers of particular interest - especially in regards to structure-activity relationships - ?
Empirical results would be great too.

So plain aminorex is considered to have a higher potential for tweaker behavior does it?
 
The medical dose was 7.5mg (Menocil) so this greenlighter speaks with forked tongue...
 
Mar

Oh yes, and the effects of aminorex are like speed, Aminorex is much more mood-altering and while not like MDMA, it's like a mix of speed & mda (less stimulating). I've had both a few times and IMHO, 4-m is fat, far better (if a little too long-lived).
 
This series of compounds really interests me but no one I know has even heard of 4-MAR let alone DMT and when i tell them pure ecstasy is MDMA there like no it's gotta be "based" with acid heroin or tweak and I tell them yeah I just make all this up for fun.
 
Does anyone have any information on N-methyl aminorex or N-methyl 4-methyl-aminorex ?

Neither of them have CAS numbers.
 
4-MA stereoisomers

Might as well resurrect this thread as make a new one.

Purely out of pharmacological interest, have any of the 4 stereoisomers of 4-MA been resolved and tested in man? Apparently all are active, but do their individual effects differ?

The isomer present in clandestine syntheses of 4-methylaminorex will depend on the choice of beta-hydroxyamphetamine; the reaction should be stereospecific for a particular beta-hydroxyamphetamine, as both heteroatoms in the starting material are retained in the product.
 
All four stereoisomers of 4-MAR have been resolved and tested seperately in mice, they were all active to some extent but there was a definite rank order of potency.

Not sure if any humans have tried it, but would be easy enough making a single enantiomer if you started from a defined isomer of norephedrine.
 
When I was younger, 4-MAX used to really excite me: a legendary clean-feeling stimulant that--for all intents and purposes--no longer exists. However, it doesn't sound that much better than good old fashioned Dexi and the cardiac risk scares me. I think I was mainly interested by the rarity, rather than the drug itself.
 
I think a better test for the seperate isomers would be to figure out which orientation might cause the hypertension and other negative side effects, rather than just if they're active or not. While it may be an overall effect of the drug regardless of orientation, its also possible that the negative effects are caused by one (or more) specific one. If so, and taking out just the side effect causing isomers left you with a pleasant drug at "higher" levels, it might be possible to explore analogues which require higher doses, such as the MD- analogue.

Of course, this wouldnt be an easy task, but it would be interesting nonetheless
 
The cyanogen bromide route yields the cis isomers (the 2nd and 3rd strongest isomers) where as the cyanate route yield the trans isomers (1st, 4th strongest isomers) The first guy who used the cyanate route was found guilty on the CSA laws since initially, it was only cis-4MAR was the isomers specifically regulated.

I would love to find out what the substituted MAR series was like. The precursor would be alpha hydroxyl and beta amino, so would it fall under the MoDA?
 
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