#xxx DALT; TRYPTAMINE, N,N-DIALLYL; N,N-DIALLYLTRYPTAMINE;
INDOLE, 3-[2-(DIALLYLAMINO)ETHYL]; 3-[2-(DIALLYLAMINO)ETHYL]-
INDOLE
SYNTHESIS: Synthesis section removed. Wait for the book and buy it!
DOSAGE: >40 milligrams orally.
DURATION: unknown
QUALITATIVE COMMENTS:
EXTENSIONS AND COMMENTARY: As far as I can determine, there has
only been a single human trial of DALT mentioned in the published
clinical literature. This was by Dr. Stephen Szara long ago,
in 1960 plus or minus a year or two. Most of the literature
papers that make reference to N,N-diallyltryptamine are reviews
of the structure-activity relationships of the psychedelics, and
thus they do not present any new human data. It is an
interesting trip to work backwards from these reviews to the
original statements that were made.
Most listed potencies are based on the generalization
that the activity of DALT was similar to that of DMT. Thus when
DMT is listed at 60 milligrams, this number appears as the
potency of DALT. And if the range of 60-100 milligrams is given
for DMT, then DALT is often stated to be at the mid-point, or 80
milligrams. I must apologize in that I am equally guilty of just
this kind of sloppy bookkeeping. All this is somewhat supported
superficially by the numbers in a chapter that Szara published in
1970 in Efron's "Psychotomimetic Drugs." In Figure I, there is
stated that a psychotropic dose of diallyltryptamine was "60 mg
i.m. or p.o." but the drug is not mentioned in the text or the
discussion. The yet earlier (and first) text mention of DALT is
in a paper by Szara and Hearst in 1962 (Annals of the New York
Academy of Science, 96 pp 134-142). There it is stated: "As
reported by Szara in Milan in 1957, administration of
diethyltryptamine (DET) and dimethyltryptamine (DMT) lead to
rapidly developing sympathomimetic effects , as well as to
perceptual, emotional and thinking disturbances similar to those
that result after administration of LSD-25 or mescaline. However
the psychological effects persist for only 1 hour in the case of
DMT and for about 2.5 hours in the case of DET; in contrast LSD
and mescaline have a much longer (6 to 8 hour) duration." There
is then added the short phrase, "The dipropyl and diallyl
derivatives have similar activities in man, as we found
recently." I finally found the Milan report of Szara: it is in
"Psychotropic Drugs," edited by Garattini and Ghetti (Elsevier,
1957). There, he describes four personal experiences: Three are
with DMT at 60, 60 and 75 milligrams, all i.m. and one was with
DET (also called T-9) at 60 milligrams, i.m. No mention is made
of diallyltryptamine.
So, the early and only discovery report of DALT mentioned
neither the synthetic preparation, the dosage taken, the route of
administration, nor the effects observed. It merely stated that
the activity had been found. I have explored it up to 42
milligrams, I was to a +1 in an hour, back to base line at the
fourth hour, and there was nothing that caught my fancy.
