Dissociatives The Small and Handy MXPCP thread

[MSK]

It surprises me the lack of engament that dissos have in BL lately, this compound doesn't have much comments jet and I expected it would explode beeing the MXE version of PCP, the original gangster! I know you all my fellow hardcore dissoheads out there are still around! Where are you?

Anyway, would like to at least add my two cents. The drug is nice, but too gentle to me. Little euphoria, little dissociation, little duration... Little everything, but pleasant for beeing around capable of doing things.

I always preferred to be hit by the hammer that hardcore ones like my favorites o-PCE or 3-HO-PCP smash in your face, I get minor effects from those not as potent dissos like MXPCP, 2-FDCK, 2-FXiPr, etc.

That said I'm sure will stock some of this one as it probably will be awesome if I try it again after clearing some tolerance. You want to stock on those 3-MeO-2-Oxo-PC[Whatever] while they last.

 

[Esperighanto]

too gentle to me

This was my takeaway too, the fact that 80mg and 470mg was experientially identical indicates there's some sort of cap on the effects this drug can induce, or it seems so at least. If I took 5.87x my dose on 3-HO-PCP or 3-MeO-PCP I would easily be stuck in a hole, not experiencing the same thing as I did on a lower dose. I did enjoy the very nostalgic, mystical character of this drug, but it feels more like a toy and less like a tool, so it falls low on my measure of interest, personally. It seems like the RC dissociative scene is on a lull right now, 2-FXiPR, O-PCP and MXPCP all have received pretty mid reviews.

 

[abc1986]

MX-PCP loses it sparkles and becomes kinda like candy but it does have this light emotional entactogenic feel to it. O-PCP is strong but lacks much distinct flavor. Put them together and I get a full disso experience. 1 part o-pcp to 3 parts mx-pcp seems to do good. It's much more complete than either alone. I do miss the psychedelic edge, stimulation, and headspace of 3-meo-pcp. At least I can say 2fxipr is almost like a way cleaner dxm and even when I had the 'good stuff' I'd find myself some dxm every once in a while but haven't wanted to with 2fxipr. I find there's not a big difference in strength between oral and nasal than either one of these, just a difference in onset and duration.

MX-PCP is way more recreational to me. But low dose o-pcp is amazing for meditation. High dose o-pcp is similar to being drunk with no hangover with the additional part where things start to take on magical meanings, but it does not become mystical for me it's more psychotic/manic adjacent. Low dose o-pcp with mxpcp like I stated at a low to mid dose is great for meditation or watching anime or movies. I rewatched evangelion neon genesis and end of evangelion like this with occasional tryptamine and phenethylamine added on top and got more out of it than ever before. It's not just a kid's show!

 

[Esperighanto]

MX-PCP loses it sparkles and becomes kinda like candy but it does have this light emotional entactogenic feel to it. O-PCP is strong but lacks much distinct flavor. Put them together and I get a full disso experience. 1 part o-pcp to 3 parts mx-pcp seems to do good. It's much more complete than either alone. I do miss the psychedelic edge, stimulation, and headspace of 3-meo-pcp. At least I can say 2fxipr is almost like a way cleaner dxm and even when I had the 'good stuff' I'd find myself some dxm every once in a while but haven't wanted to with 2fxipr. I find there's not a big difference in strength between oral and nasal than either one of these, just a difference in onset and duration.

MX-PCP is way more recreational to me. But low dose o-pcp is amazing for meditation. High dose o-pcp is similar to being drunk with no hangover with the additional part where things start to take on magical meanings, but it does not become mystical for me it's more psychotic/manic adjacent. Low dose o-pcp with mxpcp like I stated at a low to mid dose is great for meditation or watching anime or movies. I rewatched evangelion neon genesis and end of evangelion like this with occasional tryptamine and phenethylamine added on top and got more out of it than ever before. It's not just a kid's show!

You said "the good stuff", what are you referring to there?

 

[abc1986]

Even when I had 3-meo-pcp I wanted DXM occasionally. DXM was just heavy and deep but it's problem was the body load and two day hangover if I hit a high 3rd plateau. But 2fxipr scratched that itch without the big recovery costs.

 

[EnthusiastEclectic]

Received 1g of this MXPCP stuff from clearnet provider.
First 25 mg intra-nasally gave me a good mood, kind of Ephenidine like…

Does somebody know about the bioavailability when plugged? For me MXE was best plugged…

 

[Esperighanto]

Even when I had 3-meo-pcp I wanted DXM occasionally. DXM was just heavy and deep but it's problem was the body load and two day hangover if I hit a high 3rd plateau. But 2fxipr scratched that itch without the big recovery costs.

DXM is so unique, and I kind of always crave it to some degree or another. Especially with acid.

First 25 mg intra-nasally gave me a good mood, kind of Ephenidine like…

As an arylcyclohexylamine enthusiast who has yet to encounter a diarylethylamine, this is fascinating, would you say there are any other parallels between the chemical scaffolds on an experiential level you could make?

 

[EnthusiastEclectic]

As an arylcyclohexylamine enthusiast who has yet to encounter a diarylethylamine, this is fascinating, would you say there are any other parallels between the chemical scaffolds on an experiential level you could make?

Ephenidine is a dissociative gem. It's social and gave me great music appreciation and will to dance. I did Ephenidine a lot while it was clearnet available, used to called it a feelgood molecule to introduce it to my friends. They agreed! I do not know the others diarylethylamine.

 

[tuppingtoncity]

Ephenidine is a dissociative gem. It's social and gave me great music appreciation and will to dance. I did Ephenidine a lot while it was clearnet available, used to called it a feelgood molecule to introduce it to my friends. They agreed! I do not know the others diarylethylamine.

As someone who has also yet to try any diarylethylamine, would you say that ephenidine / any other diarylethylamine produce a qualitatively different dissociation than most arylcyclohexylamines. More specifically, do you think you would be able to distinguish between the two at equivalent doses in a double blind setting?

 

[EnthusiastEclectic]

I don't know… I'm kind of a heavy dosage user for the arylcyclohexylamines that I use mostly solo (except Keta that I find social too) and on the contrary I used Ephenidine in social gatherings with light to moderate dosages…
With the light 25 mg of my MXPCP discovery it was strangely similar to Ephenidine… Since I took a stronger dosage of MXPCP and I do not find it similar anymore.

I miss MXE it was my favorite! The M-holes (particularly of the MXE / Cannabis potentiation) where so greats… Travel shamanism… Is there another disso that is that good?

This lasts years I used mostly Keta in social setup and 3-HO-PCP in introspective setups… 3-Me-PCE and 3-Me-PCP are fun too… O-PCE is for me a cocktail ingredient (a light touch to balance stims)… 3-MeO-PCE is very interesting too…

 

[4DQSAR]

Steric bulk would make the synthesis a little more difficult, yet someone did it in 2019 - US-2022409555-A1

The problem as I see it is that the piperidine ring will PHYSICALLY limit it's rotation because of the ketone moiety, so it MAY not be able to bind optimally to the NMDA receptor. If it's more of a stimulant, it's likely to be acting more like BTPC which DID turn up on the RC market briefly mistrpresented as MDMA but evidently the cost of production (and a steep dose-response curve) meant it didn't last long.

Of the diarylethylamine class of NMDA antagonists, isophenidine was streets ahead of anything else (plus one-step synthesis).

Of the ketamine homologues the designer of MXE suggested that CMXE (2-chloro-5-methoxy) would likely be the 'most like' MXE and there is a patent covering it's synthesis.

People bang on about the 'next MXE' yet it appears that producers do not want to have to charge more as the precursor to CMXE would be costly thus making production more costly. But if it's even more potent than MXE (as has been suggested) then on a per-dose basis, it's possible that it is in fact cheaper than MXE itself.

If it costs $1000 to make a kg of a product where the dose is 100mg, in a product where 10mg is a dose, $5000 per kilogram would be HALF the price on a per-dose basis...

 

[isotuden]

Is it more fair to assume the harshness of this chem is due to the actual chem itself or the weird garlicky contaminant in seemingly every batch? I wonder if theres any way to clean this stuff up and make it not smell like garlic and mildew.

 

[4DQSAR]

It's an odd one because we discovered that the QSAR of ketamine homologues differed from those of PCP homologues. The description sounds quite similar to 3-MeO PCE but less potent. The latter was downright dangerous.

But it seemed that the researchers quickly identified that the cyclohexanone derivatives were more active when monosubstituted. I couldn't say why but often a patent will cover any POTENTIALLY useful homologues as 'me too' drugs were clearly known and understood and for whatever reasons, the actual patents covering ketamine are surprisingly limited. secondary amines with small alkyl moiety, an ortho chloro on the aromatic (no other halogens - why?) or an ortho or meta methoxy.

There are well over 100 US patents so clearly the research team wanted to ensure everything was protected the moment it was discovered, but a US company only obtaining a GB patent? I can only guess in the pre-internet era, doing that would result in a sort of Schrödinger's patent. Finding and obtaining foreign patents would be a costly and time consuming activity and I suspect that since ketamine was widely adopted, why develop something else? Your only competition is YOU.

BTW the OP asks why the lack of interest? Too many poor products and every time a greenlighter would appear, say how amazballz their new homologue is only for people to try and suggest it was a huge disappointment.

Unless you understand the QSAR, I guess whatever has the key moieties and the lowest price is the one that gets picked.

 

[Esperighanto]

Is it more fair to assume the harshness of this chem is due to the actual chem itself or the weird garlicky contaminant in seemingly every batch? I wonder if theres any way to clean this stuff up and make it not smell like garlic and mildew.

I went through two batches of MXPCP (one was the very first to hit the US market) and I never encountered any garlic/mildew scent in either batch. If I find my notes with the melting point and reagent reaction colors I'll update this comment, but this compound was fucking unbelievably caustic on the old sniffer. Made for a wonderful trip to a botanical garden though!

 

[4DQSAR]

this compound was fucking unbelievably caustic on the old sniffer. Made for a wonderful trip to a botanical garden though!

That's almost ertainly because whatever addition salt was produced isn't very water-soluble.

I mentioned this same thing with bupropion (née amfebutamone). Medically the almost insoluble hydrochloride and hydrobromide salts are used and I KNOW the latter was used BECAUSE of the low solubility. It meant onset was far slower.

But in the case of bupropion, I also pointed out that the sulfate salt is extremely water soluble and I'm certain the makers knew that. In effect they chose an addition salt that was certain to be painful if snorted. I would bet £1 that bupropion sulfate is virtually painless if snorted.

To be clear, I think bupropion is a terrible medication with far too many dangerous side-effects but evidently some people abuse it and a form easy to snort with a much faster onset might even be a potential RC.

That's why I suggested people take a KNOWN sample of bupropion and use all of the presumptive tests. I suggest even if not sold on it's own, it's so cheap and is so uncontrolled that if nothing else it would be an almost ideal 'active cut'.

 

[isotuden]

HELLO ALL, just wanted to share a quick PSA about this stuff. I've been researching it off and on for the past week or so and I've noticed it reliably gives me heart palpitations. Sort of a "thump, then pause, then back to normal rhythm" and it would happen at least a couple times per hour, for the entire duration of my high. This was on 70mg oral + 20mg insufflated (3-4 hours later). I've noticed this effect in doses as low as 15mg insufflated, though. I wasn't sure at first but it really does seem to cause some kind of issue with heart rhythm because I don't normally experience palpitations or anxiety bad enough to induce palpitations. I wasn't even anxious in the moment as this was happening, nor was I particularly physically stimulated or experiencing other heart related symptoms like tachychardia. Just this weird palpitation, and a slight pressure in my chest. I would warn people with heart issues or heart anxiety about this. It is bad enough that I actually threw out the rest of my bag yesterday, even though I actually really liked this stuff. I just can't justify possibly fucking my heart up.

If anyone would be willing to relay this info to the r/researchchemicals subreddit, I would be greatly appreciative. I am permabanned on reddit and unable to post, but I do want this info to get out there because it seems that MXPCP has gotten more popular as of late.

Happy researching, if anyone else has experienced this please share as well, with so little documentation and information about this substance we do need more discussion on this

 

[Innerpeace]

What a rush! But not much insight or depth to it. I think this would be really good for dancing and not really talking.

When you say rush , what does rush to you?

Does this mean extra dopamine and nor adrenaline releasing compared to less "maniac" dissos like ket ?