Stimulants The Science of Meth Neurotoxicity and Strategies for Prevention and Treatment (2021 version)

[Jabberwocky]

I don’t recall seeing this article posted previously.

Frontiers | The Main Molecular Mechanisms Underlying Methamphetamine- Induced Neurotoxicity and Implications for Pharmacological Treatment

Methamphetamine (METH) is a popular new-type psychostimulant drug with complicated neurotoxicity. In spite of mounting evidence on METH-induced damage of neu...

www.frontiersin.org

It seems an excellent summary and provides evidence for various personl remedies recommended in other good threads on this topic like this one from 2 years ago:

Stimulants - Meth neurotoxicity and my loud pill box of meds and remedies!

Methamphetamine is a serious neurotoxic substance so is not silly to tackle this problem to reduce harmful tragedies at the end of the road! So I have two boxes fill with great psychotropic that I love or just need. The first one is an small wooden box that I have all my stimulant, psychedelic...

www.bluelight.org

 

[Skorpio]

A bit of a dig, but I would be remiss to not link the 3 classic Epsilon Alpha threads going into amphetamine tolerance and neurotoxicity mitigation.

Amphetamine Neurotoxicity and Tolerance Reduction/Prevention

Hello, I'm Delta Gamma from Imminst, a while back I made a thread about preventing some of the negative consequences of amphetamine use particularly at AD(H)D dosage patterns which can be found via the link below. I believe that this information may be more appreciated by this audience. NOTE: I...

www.bluelight.org

Amphetamine Neurotoxicity and Tolerance Reduction/Prevention II

Link to previous thread: http://www.bluelight.ru/vb/threads/577851-Amphetamine-Neurotoxicity-and-Tolerance-Reduction-Prevention The Basic Stack. - ~250mg elemental magnesium at bed. Why: magnesium deficiency is extremely common and known to worsen neurotoxic measures in mouse models. May also...

www.bluelight.org

Amphetamine Neurotoxicity and Tolerance Reduction/Prevention III

Links to previous versions: Amphetamine Neurotoxicity and Tolerance Reduction/Prevention Amphetamine Neurotoxicity and Tolerance Reduction/Prevention II Amphetamine Induced Changes in Protein Degradation and Apoptosis: PKCδ as a Central Regulator Introduction: Amphetamine (AMP) and...

www.bluelight.org

These threads really cover some theoretical ground but have really valuable discussion of a lot of papers included.

 

[Jabberwocky]

A bit of a dig, but I would be remiss to not link the 3 classic Epsilon Alpha threads going into amphetamine tolerance and neurotoxicity mitigation.

I don’t mind the dig and I’m really glad you posted the links to those threads. I’ve actually searched a few times for what we have on stimulant neurotoxicity, including today before I posted the paper above, and those 3 Epsilon Alpha threads never appeared in the results that I can recall.

At any rate though, i don’t think there is any harm in having this thread in Other Drugs while the earlier ones are in in NPD. I don’t know to what extent these sub-forums get the same readers but OD still does get a lot of basic questions about meth damage and mitigation.

Thanks for the leads.