• N&PD Moderators: Skorpio

The problem with memantine for amphetamine tolerance atenuation in the treatment ofS

MeDieViL

Bluelighter
Joined
Feb 11, 2007
Messages
3,190
Location
Belguim
Quote from my paper regards to novel treatments for sa and depression; tolerance issues with many drugs that have a host of therapeutic benefits.

Fortionally there's a solution for this (this also apply's to the use of benzo's) tolerance to those drugs is mostly nediated by DA and nitric oxide; the most popular used agent that targets nnDA and counteracts those tolerance issues is menantine. Menantine is a nmda antagonist effectively preventing tolerance issues for the many people that have been using this agent.One problen with this is that nmDA facilates fear extinction (wich is basicly getting over social anxiety by therapy and exposure) and menantine will inhibit this.
A very promosing alternative for this is the blue dye methylene blue; MB facilates fear extinction while also possibly more effectively preventing tolerance and withdrawal issues due to the depletion of glutamate and nitric oxide.

Id also like to point out that many individuals that use amphetamine for social anxiety dont even need it, i say this because on the right supplements i was able to induce fear extinction so that after several weeks i felt comfortable in social situations without having to use amphetamine; while the ammount of exposure was only a minimal fraction of the exposure i had for much longer periods on several ocasions years ago.
This is where AVPD and SA differ; AVPD needs extra supplementation wich frangible pointed out years ago before FE can take place; otherwise the chronic use of stimulant drugs may be required; currently its inclear for how many the use of supplements can replace the need of amphetamine.

Aside from this; its allways a good idea to allow FE to take place; instead of supressing it with drugs like memantine; however at this time the use of MB for tolerance is only a hypothesis of me; id like to see some reports.
 
What the hell did I just read? No citations or coherence, fix this and I'll leave this open. If not its closed next time I come by.
 
What the hell did I just read? No citations or coherence, fix this and I'll leave this open. If not its closed next time I come by.
Respect that i am dutch.

I will post some references soon showing nmda antagonism blocks fear extinction; that glutamate potentiaters potentiate it has also been well shown and why AVPD has relevance to shizophrenia.

I work tomorrow so give me some time.
 
EA said:
What the hell did I just read? No citations or coherence, fix this and I'll leave this open. If not its closed next time I come by.

Er....it was a bit heavy on the acronyms and strayed from the original topic (indeed, it's not clear why this is specific to memantine), but I could understand it.

ebola
 
I understand that antagonism of NMDA channels can cause the issues that you mention but isn't the way mementine antagonize the receptors similar to say Mg2+, in that they are both easily displaced from the receptor not limiting the interaction of glutamate and the receptor avoiding causing say an interrupting of memory formation, fear conditioning, etc? I know that antagonist like ketamine, dxm, pcp, etc. can have a lot of deficits during and a short peroid after use in these areas, but I thought mementine was good in the fact it causes its effects while there isn't direct activation of the receptor
 
Respect that i am dutch.

I will post some references soon showing nmda antagonism blocks fear extinction; that glutamate potentiaters potentiate it has also been well shown and why AVPD has relevance to shizophrenia.

I work tomorrow so give me some time.

Yeah, sorry MeD forgot about the language barrier.
But, I trust you'll make a decent thread given the chance. Currently in the middle of hell week as far as school goes so I'm pulling 20 hour days studying/working forgive my bitchyness
 
Top