Extraction of Generic Oxycontin - Abuse-Proof
mallinckrodt has generic Oxycontin on the market and i ended up getting these on my last fill. Usually i get brand or watsons, but I thought generics for OC had been discontinued, of course i was wrong..
Anyways after researching tons of ways to defeat the time release (Crisping, A/B Extractions etc), I found an interesting patent that defines exactly how the Gel mechanism works. Known as HVLCM High Viscosity Liquid Carrier Material which is also functions as the controlled release mechanism.
While long it does provide objective scientific evidence on many of the extraction methods discussed. what is interesting is the method that yielded the best results after 60 minutes was extracting in coke-cola, at 60C, fairly hot. This yielded about 40-60% extraction.
i would expect a sloped curve in terms of extraction, meaning first hour you may see 30-60%, but leaving for 5 hours wouldn't mean 100%. Considering most other methods are 1-10% (Microwave, Crushing, etc) this isnt too bad. The remanning unextracted portion would still be metabolized just as controlled release.
Of course DO NOT INJECT COKE-COLA, or any pills for that matter. There are other threads on that subject, but for oral ingestion of any type of opiate, using a filler that gels on contact with water the following process seems to work. I havent tested on all, but Mali Oxycontin, Teva, and Opana have had good results, better then all the other methods I have tried.
1. Crush the entire pill, with the outer shell
- Notepatent seems to indicate that outer-shell may contain ingredients that aid in the absorption of the active ingredient, the good stuff.
2. Use 250ml or a shotglass filled 2/3rd of the way with coke-cola
3. Heat in microwave for about 30 seconds, it will heat quickly so watch it
4. Mix powered pill with heated coca-cola
5. Stir
6. Let sit for 90 minutes
7. Drink
Suggest while letting it sit to stir periodically and try to keep temp around 60C. Microwaving in short burst of 5-15 seconds should do the trick.
Expect anywhere from 40-60%+ to be extracted, which isn't that bad considering the alternative. Also the extracted coke-cola solution isn't as disgusting to drink as opposed to vinegar, lime, water, crisping and some of the other crazy methods I have seen..
I am very interested to hear what others think about this.. MODS: Please let me know if this is in the appropriate thread\forum..
Reference Article:
http://www.wipo.int/pctdb/ja/ia.jsp?ia=US2008%2F013381&IA=US2008013381&DISPLAY
ESC
Reference:
Household Solvents..
"when exposed to extraction in saturated baking soda solution at 60° C for 5 minutes, the dosage form releases less than about 15% of the opioid, preferably less than about 11% of the opioid; (1) when exposed to extraction in a cola soft drink at 60° C for 5 minutes, the dosage form releases less than about 45% of the opioid, preferably less than about 30% of the opioid; (m) when exposed to extraction in 100 proof ethanol at 60° C for 60 minutes, the dosage form releases less than about 33% of the opioid, preferably less than about 26% of the opioid; (n) when exposed to extraction in vinegar at 60° C for 60 minutes, the dosage form releases less than about 33% of the opioid, preferably less than about 20% of the opioid; (o) when exposed to extraction in saturated baking soda solution at 60° C for 60 minutes, the dosage form releases less than about 33% of the opioid, preferably less than about 23% of the opioid; (p) when exposed to extraction in a cola soft drink at 60° C for 60 minutes, the dosage form releases less than about 60% of the opioid, preferably less than about 45% of the opioid; (q) when exposed to extraction in a panel of extraction solvents including vinegar, hot tea, saturated baking soda and a cola soft drink, each at 250C for 60 minutes, releases less than about 20% of the opioid, preferably less than about 15% of the opioid; (r) when exposed to extraction in a panel of aqueous buffer extraction solutions ranging from pH 1 to pH 12, each at"
Microwave..
"As can be seen by these extraction results, only 4% (1.6mg) or less of the oxycodone dose was extracted from the microwaved Test Capsules after 5 minutes of extraction in each of the extraction liquids. After 60 minutes, only about 14-10% of the oxycodone dose was extracted in any test liquid. These data show that the Test Capsules resist rapid extraction or dose dumping"
Smoking/Chasing
(very bad for you, and not efficient at all)
"Test Capsules and the single lot of SR Control tablets were evaluated in triplicate. Each Test Capsule was cut open and the liquid contents squeezed into a sample dish, and each SR Control tablet was ground with a mortar and pestle and then transferred to a sample dish. The aluminum block was stabilized at 2800C prior to initiating the study. The covers were swabbed for oxycodone at 3, 5 and 10 minutes, and the samples were analyzed using HPLC. The results of the volatilization study were as follows: average oxycodone recoveries following volatilization at 2800C (data in the form of mean oxycodone recovered with standard deviation (SD), reported as a % of initial dose): Test Capsules = 2% (0.8) at 3 minutes; 4% (2.1) at 5 minutes; and 12% (2.1) at 10 minutes. SR Control tablets = 12% (2) at 3 minutes; 11% (2) at 5 minutes; and 10% (2) at 10 minutes. These data are depicted in Figure 19."
Chewed:
Increases absorption rates, but does not defeat time-release/anti-abuse mechanism(s). Peak (plasma levels) decreases from about 4 hours to 2 hours by chewing. Coke-Cola extraction process described above accomplishes the same a chewing, i.e. powering the pill. So roughly 40-60% of the total dosage will be effectively the same as instant release, peak less then 1 hour with remaining 40-60% absorbed the same as chewing.
"As can be seen, vigorous mastication (chewing) of the OXY Test Capsules increased the mean Cm3x from 40.5 ng/mL to 82.3 ng/mL. However, relative to the IR Control oral solution, the C1112x for the chewed Test Capsules was significantly lower and occurred at a significantly later time. The mean T1113x for the chewed OXY Test Capsules decreased from 5.52 hours to 2.67 hours, as compared to 1.07 for the IR Control oral solution."
Bio Availability:
Oxycodone: Very good orally, 85-95%
"inally, the relative bioavailability based upon the AUCiast of the three 80mg Test Capsule formulations (OXYl- OXY3) was very good (>80%, ranging from 83.39% to 90.27%"
