Sprout
Bluelight Crew
Well fuck... just been doing some fairly standard journal scouring (what?! Don't even pretend you thought I had a life!) and stumbled across couple of scant pieces regarding Levamisole and in particular its application to the Cocaine trade.
It's well accepted that Levamisole presented an intriguing addition given its infamous antihelminthic and immunosuppressant (to chemotherapeutic extent...) properties which are not carried by the more fiscally viable options such as Mannitol while presenting zero in terms of positive acitivity addiction. The true reason may be much smarter than ever anticipated.
At low doses Levamisole acts as little more than a toxic excipient (comparative activity: 0.015-0.03% Coke) but once its serum concentration becomes appreciable its metabolic fate becomes one of clinical interest. That product being the infamous Aminorex.
Aminorex is theorised to possess tricyclic activity but with the fun little quirk of its SERT modulation being that of reuptake inhibition, rather than release as is its function at DAT and NET. Now given Cocaine itself possesses low but clinically significant SRI activity and Aminorex having an effective half-life exceeding that of its compatriot it would not be too unreasonable to suggest that the combination could be much greater than the sum of its parts - providing a more balanced effect profile with a unique profile that cannot be matched even by 100% pure relevant isolates and a duration extended beyond the perils of the cliff of Coca.
Levamisole --> Aminorex bioconversion
Aminorex 5-HT reuptake properties
Cautionary review of Aminorex type toxicity in Cocaine abuse
Angranulocytotic capacity of Levamisole is of a rate-limiting step
It's well accepted that Levamisole presented an intriguing addition given its infamous antihelminthic and immunosuppressant (to chemotherapeutic extent...) properties which are not carried by the more fiscally viable options such as Mannitol while presenting zero in terms of positive acitivity addiction. The true reason may be much smarter than ever anticipated.
At low doses Levamisole acts as little more than a toxic excipient (comparative activity: 0.015-0.03% Coke) but once its serum concentration becomes appreciable its metabolic fate becomes one of clinical interest. That product being the infamous Aminorex.
Aminorex is theorised to possess tricyclic activity but with the fun little quirk of its SERT modulation being that of reuptake inhibition, rather than release as is its function at DAT and NET. Now given Cocaine itself possesses low but clinically significant SRI activity and Aminorex having an effective half-life exceeding that of its compatriot it would not be too unreasonable to suggest that the combination could be much greater than the sum of its parts - providing a more balanced effect profile with a unique profile that cannot be matched even by 100% pure relevant isolates and a duration extended beyond the perils of the cliff of Coca.
Levamisole --> Aminorex bioconversion
Aminorex 5-HT reuptake properties
Cautionary review of Aminorex type toxicity in Cocaine abuse
Angranulocytotic capacity of Levamisole is of a rate-limiting step