The Old and Overgrown 2C-E Thread

[JuicyJay]

yea, it's 2c-e Doesn't seem to be doing much other than making me feel sick. I feel stoned with a little bit of a headache.


I feel much better now, nausea wise. I feel like I have lots of engery and I want to move move move. It's got a touch of trails and waviness. My neck and back feel a little tense while my stomach is concaved because I still haven't eaten. The breakfest I made just didn't seem good anymore when I went to eat it. In a happy mood now.

 

[Xorkoth]

2C-E takes a while to come up (up to 3 or so hours to really get into it), and nausea is usually a side effect until then. Don't worry much, nothing you can do about it now. In the future, use a better scale, or calibrate the one you have, measure out something like 100mg, and dissolve it in liquid at 1mL=1mg so you can dose accurately, as discussed in your DOI thread. Rest assured that 2C-E seems pretty safe physically... but mentally you could be in for a ride. Just remember it'll be fine in the end. If you need to, read my experience report of an absolutely terrifying but in the end, one of the best trips of my life (on 18mg):

http://www.erowid.org/experiences/exp.php?ID=48983

 

[JuicyJay]

I have 100mg set a side for the water suspension dosing. I just wanted to test the waters...and I think I'm doing fine. The visual effects are really starting to kick in Low BASS does well hahaha. I think I am going to buy a better scale though, because this CAN NOT happen with DOI and I know that. Will fresh ginger STOP the nausea? There has to be SOMETHING to get rid of that nastiness! When the nausesa was still there everything was jumbled and I didn't want to move, talk, think. It felt like I was in a bad trip in my head. Am I going to feel like that....every time I come up?

 

[Xorkoth]

Ginger might help, but the nausea should end as the trip swings into full force. Or at the least, after the peak you'll feel great.

Yeah, nausea does that to me sometimes too, regardless of how much I realize it shouldn't. Just goes to show how intimately tied in our bodies are with our minds. But yeah, every time I have an uncomfortable come-up, I usually go through a period of wishing I hadn't taken it. It just comes with the territory, but also it gets easier the more you do it. Also, somehow, I don't seem to get uncomfortable comeups with phenethylamines anymore very often at all.

 

[Church]

I just got rid of some crap posts, now please remember this is a B&D thread, people.

And no more "I'm tripping right now" posts, Juicyjay.

 

[DeanDouglas]

Question...I've been wanting to try 2C-E for a while. How deep does it go compared to let's say DOC? And do the two compare in any kind of way by any chance?

 

[Beenhead]

Never done DOC, but 2CE is very very deep and terrific in every way a psychedlic can be. It also does not last 18 hours or more wither. It usually lasts about 9 hours with stronger doses. Just about anyone here who has done 2c-e would probably agree

 

[DeanDouglas]

Ah, okay. I should try to get some then. I've heard it's not worth it though, I'm guessing due to body load or something.

 

[ecstasteve]

Personally, I never understood the hype over 2C-E. It sounds kinda like a dud to me. I'd much rather have 2C-D, or 2C-B for that matter.
[ 22 October 2002: Message edited by: morninggloryseed ]

Then you have never done it. 2c-e is wayyy better then any 2c-x compound. Its highly visual and will blow your balls off.

I like doing my doses at a minimum 25mg.

 

[Morninggloryseed]

2C-E has the least side effects, body load, etc. of all of the 2Cs I have tried. Only the slightest trace of the signature phenethylamine jaw clenching, heart racing, skin burning stimulation. Definetely one of the best as far as phenethylamines go.

Although 2C-E (and 2C-T-7) are the real gems in my book, I must say 2C-B, 2C-C, and even 2C-D are easier on the body all around. Easy come-ups...especially with 2C-C.

The come-up with 2C-E was pretty rough for me. No severe nausea (ie 2C-T-2 and 2C-T-7) but a LOT of energy. But it doesn't last long, and it smooths out when the peak hits. Easy sailing from there.

 

[Xarann]

body load?

I recently got my hands on a gram of 2c-e, and plan to try 10mg shortly.

I have no experience with other 2c Rcs, my only previous phenethylamine experience is with MDMA and whatever derivates could be present.

I assume the common high energy associated with the side effects of jaw-clenching are because the 2c's are active at certain receptors common to meth/amphetamines, i would like some confirmation on this if possible tho.

Also is there any information available on why there is a general report of some type of body load, usually nausea / diarrhea ?
This just doesn't sound too good to me, is it because of the toll is takes on the liver? i would like any information or to be pointed to any source if available, errowid doesnt have anything.

 

[who]

I recently got my hands on a gram of 2c-e, and plan to try 10mg shortly.

I have no experience with other 2c Rcs, my only previous phenethylamine experience is with MDMA and whatever derivates could be present.

I assume the common high energy associated with the side effects of jaw-clenching are because the 2c's are active at certain receptors common to meth/amphetamines, i would like some confirmation on this if possible tho.

Also is there any information available on why there is a general report of some type of body load, usually nausea / diarrhea ?
This just doesn't sound too good to me, is it because of the toll is takes on the liver? i would like any information or to be pointed to any source if available, errowid doesnt have anything.

ahhh, it's a RC so there isn't alot of info on it. Hence errowid has all it can ATM. Check trip reports about 2c-E and maybe ask someone like FastandBulbus why certain chemicals cause certain "bodyloads" that or I think his name is Psychedelics r Best. They both have a very good grasp, or in my opinion, on organic chemistry and it's application to humans and psychedelics. Also, as I said there is almost no bodyload with 2c-E, it feels so fucking clean. The only thing I notice is a little "jittery legs" and slight case of the yawns on the come up.

 

[Xarann]

ahhh, it's a RC so there isn't alot of info on it. Hence errowid has all it can ATM. Check trip reports about 2c-E and maybe ask someone like FastandBulbus why certain chemicals cause certain "bodyloads" that or I think his name is Psychedelics r Best. They both have a very good grasp, or in my opinion, on organic chemistry and it's application to humans and psychedelics. Also, as I said there is almost no bodyload with 2c-E, it feels so fucking clean. The only thing I notice is a little "jittery legs" and slight case of the yawns on the come up.

Yeah, i understand is a RC.

But for example there (2c-'s) related to mescaline, wich has similar body load reports, and has been used for 1000s of years. So i would think there is at least some general idea of why such a body load happens when they are not common with say tryptamines (and lsd)

 

[who]

Like I said ask one of the local gurus, i.e. FastandBulbus <--- he knows and sees all *waves hands in a mystical sort of way*

 

[gloggawogga]

I think most of the body load, jaw clenching, etc. is basically displaced emotional stress. Some drugs are more condusive to this effect than others. People do get body load from LSD and tryptamines. The phenylamines may be a little bit more notorious, due to activity on noreprinephrine and dopamine.

 

[hugo24]

Not sure if we have (enough) data to say the phens have more activity on dopamin resp. noradrenaline.Think about LSD,AMT,AET,plus we have pure stimulants in the tryptamin world as well.If pulse and blood pressure is any measure of stimulative/DA/NA activity,I have yet to see ANY psychedelic raising these numbers!

2C-E specifically might have a bit a higher body load,the psychological cause gloggawogga suggested is probably a good explanation as 2C-E is working much deeper than other chems.But I must say on the peak,it is very calm and not at all stimulating.And sleep afterwards comes easy and is restful.

 

[Xarann]

Well i've been trying to dig further, and it seems phenethylamines, especially 2c-'s, can be active on the 5-ht3 receptor (wich are supposedatly especially present in the gut) and are responsible for nauseous feelings / diarrhea.

Also, from wikipedia
http://en.wikipedia.org/wiki/5-HT_receptors

5-ht3 is very different from other serotonin receptors, as in it's a ligand gated ion channel rather than a G protein-coupled receptor like all the others (like 5-ht2a wich is reponsible for much of the psychedelic effect of pea's/tryptamines/lsd).

Also have read tryptamines can also act on 5-ht3.

I haven't been able to find information saying where they are located other than the gut (they very well may be, this is lack of information), but this is inconsistent with reports of snorting 2c-'s creating a heavier body load than ingestion.

I think most of the body load, jaw clenching, etc. is basically displaced emotional stress. Some drugs are more condusive to this effect than others. People do get body load from LSD and tryptamines. The phenylamines may be a little bit more notorious, due to activity on noreprinephrine and dopamine.

I think the "body load" (characterized by nausea / diarrhea) has a completely different system of action than the high energy/jaw clenching.
The norepinephrine/dopamine theory sounds very likely as cause tho, since as far as i know tryptamines do not act on those, yet they seem to be known causes of the increased heart rate / high energy and maybe jaw clenching side effect of amphetamine.

Not sure if we have (enough) data to say the phens have more activity on dopamin resp. noradrenaline.Think about LSD,AMT,AET,plus we have pure stimulants in the tryptamin world as well.If pulse and blood pressure is any measure of stimulative/DA/NA activity,I have yet to see ANY psychedelic raising these numbers!

2C-E specifically might have a bit a higher body load,the psychological cause gloggawogga suggested is probably a good explanation as 2C-E is working much deeper than other chems.But I must say on the peak,it is very calm and not at all stimulating.And sleep afterwards comes easy and is restful.

reading trip reports on errowid, i can upon 3 where people mesured pulse/blood preasure, and all seemed to report numbers from the 50% to 100 higher.

it only makes sence that 2c-'s are active on dopamin/noradrenaline, since some of it's cousins in the phenethylamines family cause similar side effects, and are well known to act on those (referring to amphetamine/methamphetamine here)

 

[hugo24]

Of course I too have had raised BP/PR on psychedelics,but after sorting it out,it was always entirely psychological.Simple and undisturbed tripping never raised them,try that with speed,its impossible.

 

[Xarann]

Of course I too have had raised BP/PR on psychedelics,but after sorting it out,it was always entirely psychological.Simple and undisturbed tripping never raised them,try that with speed,its impossible.

Well "psychedelics" is quite a broad range to theorize on. for the 2c-'s and other RCs in that family it does seem more likely, since they are all phenethylamines, wich also includes "speed"(amphetamine) wich you mention.

 

[Delsyd]

i agree with glogg that the nausea could very well be psychologocal.

Iv had ~5 trips on 2c-e and only vomited once. That one time happened on my strongest 2c-e trip.

2c-e is probably one of the deepest most powerful psychedelic i have tried (out of ~2 dozen).