amapola
Bluelight Crew
Snorting morphine with chitosan is interesting.
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muvolution
Bluelight Crew
just saw your other post on chitosam. This shit sounds interesting.
With an infinite supply of opiates, I would def choose morphine above all others, but it is shitty that the BA is ~30% no matter how you do it up unless you IV it.
Captain.Heroin
Bluelight Crew
Damn, what about all the injection users? Are they shooting oxycodone & morphine?
Bah stupid California I wish we had #4
Some people in CA can get #4 I am sure, it's just not common.
In CA you have meth, you should be delighted. %)
You could IM morphine for a close to 100% BA. But that's an unpopular choice among many people for whatever reason.Does anyone happen to know what exactly is responsible for morphine's low oral BA? Where/how is it metabolized? Could the metabolism be slowed / countered with and enzyme inhibitor or a similar method?
a-googling-I-shall-go, but if you know anything on the subject feel free to chime in
Yea, I'd bet it just comes through in personal / head stash amounts for the most part though. I've never come across it. I've come across the 'powdered tar' stuff that the mexicans seem to be partially switching over to, its alright (a hell of a lot better than black tar), but for IV use (which I am ever-fond of) it still doesn't compare to water-soluble #4.
Yeah. I do enjoy a nice barrel of meth every now and then. The quality around here is outstanding, but at least in my area (monterey bay, norcal) the price has skyrocketed. Can't discuss it obviously but I'd bet its higher than the majority of the country. Maybe not IDK. Of course everything is different if you know the cook, of if you friend knows a cook. But alas, I do not.
amapola
Bluelight Crew
Extensive first past metabolism in the liver. Minor substrate of errr CYP2D6 I guess as diphenhydramine is common but not that effective so must be something other than cyp i guess. If you could get it to cross the nasal or lower rectal membrane better (chitosan in nose or maybe pH of rectal solution) it would be your best bet. Other than /IV/IM/CC of course.
This is all from what my tired mind is dragging up so I could be mistaken...
Captain.Heroin
Bluelight Crew
Does anyone happen to know what exactly is responsible for morphine's low oral BA? Where/how is it metabolized? Could the metabolism be slowed / countered with and enzyme inhibitor or a similar method?
a-googling-I-shall-go, but if you know anything on the subject feel free to chime in
The reason why morphine has a poor oral BA is because when it is taken orally, it is subjected to first-pass metabolism by the liver, and the liver breaks down a lot of it via glucuronidation into morphine-3-glucuronide and morphine-6-glucuronide.
I included the most info although you beat me to the explanation of first-pass metabolism.
amapola
Bluelight Crew
^Actually that is CYP3A4 but yeah nothing to inhibit glucuronidation that I know of. As I said just try and bypass the hepatic portal system all together.
Whats CC? Did you mean to type SC?
amapola
Bluelight Crew
Yeah subcutaneous
muvolution
Bluelight Crew
IF I had a pure drug solution meant for injection, I wouldn't mind some IM/SC action, but you rarely find street drugs in class ampules suitable for injection.
I THINK (no facts, just experience) that Morphine's BA can be boosted by doing sub-lingual.
I've been taking my dilaudid this way. I usually crush up like 8mg (2 pills) with 2 Chewable dramamine (for that great raspberry taste) and just like a tiny, tiny touch of loose snus or something to cut up my gums so it can transfer through more easily.
amapola
Bluelight Crew
Haha what?
Snus -
Chewing it makes little cuts along the gums. Which allows for better absorption(?)
How long do you usually keep your sublingual mix under your tongue, and do you try to abstain from swallowing or no? Everytime I try something sublingual I end up giving up after like 5 minutes and end up just swallowing the mess.
amapola
Bluelight Crew
Haha ummmm don't think so. How would blood spewing out of your gums aid in absorption
amapola
Bluelight Crew
muvolution
Bluelight Crew
Ew. More like:
Well I don't think there is glass in it, haha, but it does have salt and sugars that aren't solute, so the crystals cut your gums up a bit, (not to the point they are bloody or anything) but just so that the drug can creep through better. I don't smoke or do smokeless tobacco for any other reason than this, and even then its occasional.
I usually get swedish snus as the american is too moist and makes you want to spit. The also didn't have snus here for a long time.
Also, a tin will last me like 6 months - long enough that it gets stale before I can use it.
I also don't go under my tongue, per say, more like a dip that you keep in your lower lip. I try to spread it out to maximize surface area, and I leave it in until it is all dissolved. I try not to swallow, and don't usually produce alot of saliva doing this, either that, or it gets sucked into the mixture and absorbed into the MM in my mouth. If I do swallow it though, it's not like the end of the world as hydromorphone is still pretty active orally.
The raspberry flavored dramamine chew tabs really help with the taste and wanting to spit it out part. Also, I try to crush up the pills jaggedly so that they put tiny little cuts into my gums also, or I'll give myself an unusually strong tooth and gum-brushing before I dose.
Usually I take like 12mg or so for pain (legitimate pain) orally, but using this method I can use 8 (one less pill) and be nodding off instead of just not being in pain.Ya know, I've actually never tried snus (its almost like the name turned me off of it :D). I've gone through more than a few cans a dip before (when trying to avoid smoke for various reasons), and actually it can be kind of nice at times.
muvolution
Bluelight Crew
I like snuff.
I don't smoke but I'll snuff once in a while. especially at parties since I can mix in powdered pills before hand and just use my snuff box all night long.
Snus (outside of my use for it in this particular instance) is generally pretty gross. I hate spitting, I like the bone-dry snus from europe.- Status
