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The Large and Nifty Not-quite-advanced Drug Chemistry, Pharmacology and More Thread

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I just tried gabapentin the other day, and I experienced extensive visuals both eyes open and closed. I'm curious now, what mechanism could gabapentin have to cause this? My understanding is that it's mechanism of action is similar to that of pregabalin, but I never experienced anything similar on pregabalin.
 
That is HIGHLY unusual for gabapentin ... no real help, I know, but I'd be very suspicious if there couldn't be other reasons for your experience.

- Murphy
 
i haven't tried gabapentin, but doses of pregabalin around 1g produce pretty nifty open eye visuals for me. its hard to describe what they were like. i mostly saw them on blank, white surfaces. it sort of reminded me of the whispy, smokey visuals that some serotonergics produce on white surfaces, but it was still pretty different.
 
I have peripheral neuropathy

I use to take gabapentin 900 mg - 3 times a day

I use to abuse it

I would take 3 grams at a time

the shit would speed me up like meth minus euphoria

my point for this drug-addled story is that I too have had atypical effects from gabapentin
 
MurphyClox said:
That is HIGHLY unusual for gabapentin ... no real help, I know, but I'd be very suspicious if there couldn't be other reasons for your experience.

- Murphy
Click to expand...

Well I don't see what else could have caused it. I didn't do any other drugs that day.

Something about those visual effects was weird. Like I would try to watch a movie on tv, it turned out to be impossible - it felt like my brain didn't process the visual information fast enough, every time the camera angle changed in the movie it took a second or two for me to grasp the visual information and see the picture again...

I also experienced some nystagmus. Eyes closed, I saw colourful patterns, not fractal-lice but more chaotic.

Granted, the dosage I took was quite large (around 7 grams).
 
dread said:
I just tried gabapentin the other day, and I experienced extensive visuals both eyes open and closed. I'm curious now, what mechanism could gabapentin have to cause this? My understanding is that it's mechanism of action is similar to that of pregabalin, but I never experienced anything similar on pregabalin.
Click to expand...

Gabapentin causes pretty wacky visuals in me, not like those of psychedelics but usually more simple and blurrier. When you combine with opiates things get really weird, once I had about 2 grams of gabapentin with 15mg hydrocodone and went to watch some fireworks, and I couldn't tell the normal sky from the fireworks about half the time! Not to mention everything was extremely blurry. Really weird stuff.
 
Could gabapentin produce visuals in a manner similar to the Z-drugs? Are the mechanisms of action similar?
 
nuke said:
Gabapentin causes pretty wacky visuals in me, not like those of psychedelics but usually more simple and blurrier. When you combine with opiates things get really weird, once I had about 2 grams of gabapentin with 15mg hydrocodone and went to watch some fireworks, and I couldn't tell the normal sky from the fireworks about half the time! Not to mention everything was extremely blurry. Really weird stuff.
Click to expand...

Well that explains somewhat, I have a buprenorphine medication so it might have interacted with the gabapentin somehow?

Yeah the visuals I got were nothing like those you get on psychedelics - in a way they're completely opposite... on psychedelics, the visuals feel like the brain is over-processing all the visual input, while on gabapentin it feels like the brain doesn't process the visual input fast enough...

...what is the safety margin of gabapentin?
Click to expand...

I understand it to be pretty wide... even a dosage of several grams doesn't seem to cause any notable adverse effects (except for a terrible dryness of mouth.)
 
MurphyClox said:
...what is the safety margin of gabapentin?
Click to expand...
Apparently quite wide. I've seen my wife take 50 grams (not a typo) of the stuff on more than one occasion, without any obvious problems.

I recently noticed closed eye visuals (quite enjoyable) for the first time, I'm sure they've been there all along had I looked for them. This was at I think 3600 mgs.
 
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fryingsquirrel said:
Apparently quite wide. I've seen my wife take 50 grams (not a typo) of the stuff on more than one occasion, without any obvious problems.

I recently noticed closed eye visuals (quite enjoyable) for the first time, I'm sure they've been there all along had I looked for them. This was at I think 3600 mgs.
Click to expand...

These are noteworthy too actually, especially with opiates. Normally I get dreamy sorts of states with opiates, but when I mixed hydrocodone with gabapentin on another occasion, when I closed my eyes I would have really vivid full-blown fantasies, like I imagined I was in another room and was wandering around the room looking at different objects and for a while thought I was actually in it

The safety margin is high, but you have to be careful about it. After some really large doses I got really bad tremors and I would be afraid that if you used it regularly for a while and suddenly stopped it might cause seizures, like benzodiazepines. But that I mixed it with relatively high doses of hydrocodone (for me, 20mg is a strong dose), seemed to indicate it was all too good at respiratory suppression. I think my highest dose was 6 grams, but that was before I knew about the weird absorption. Now 1200mg spaced over a longer timeline has the exact same effect.
 
why do amphetamines sedate me in low doses? does this happen to every person or only to people who are diagnosed with attention disorders

would the mechanism be related to serotonin. eg MDAI really sedates me
 
melange said:
I have peripheral neuropathy

I use to take gabapentin 900 mg - 3 times a day

I use to abuse it

I would take 3 grams at a time

the shit would speed me up like meth minus euphoria

my point for this drug-addled story is that I too have had atypical effects from gabapentin
Click to expand...

are you surer this is atypical effect? me and everyone ive talked with who abused pregabalin or gabapentin and large doses seem to be stimulating in a sense indeed (you can still sleep but you dont feel the need to)

for me to reach this i have to take large doses (1g pregabalin which is like what, 15g of gabapenting 8o)

Yerg said:
Could gabapentin produce visuals in a manner similar to the Z-drugs? Are the mechanisms of action similar?
Click to expand...

No
 
4-MeMABP

Seeing as the thread on this topic has been closed I thought I would ask my question here.

This morning I recieved a sample of this compound, I've done an allergy test with 1-2mg and all seems good so far, I haven't had a reaction and I haven't dropped dead.

The thing i'm worried about is toxicity, I know it will be toxic as para substituted cathinones always are but just how toxic are we talking? I know no one can give me a definative answer I just want some reasurance that i'm not going to drop dead.
 
kken said:
are you surer this is atypical effect? me and everyone ive talked with who abused pregabalin or gabapentin and large doses seem to be stimulating in a sense indeed (you can still sleep but you dont feel the need to)
Click to expand...
Agreed, I don't believe those affects atypical at all.
 
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